Collagen Prolyl Hydroxylation-Dependent Metabolic Perturbation Governs Epigenetic Remodeling and Mesenchymal Transition in Pluripotent and Cancer Cells

Collagen prolyl hydroxylation (CPH), which is catalyzed by prolyl 4-hydroxylase (P4H), is the most prevalent posttranslational modification in humans and requires vitamin C (VitC). Here, we demonstrate that CPH acts as an epigenetic modulator of cell plasticity. Increased CPH induced global DNA/hist...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2019-07, Vol.79 (13), p.3235-3250
Hauptverfasser:	D'Aniello, Cristina, Cermola, Federica, Palamidessi, Andrea, Wanderlingh, Luca G, Gagliardi, Miriam, Migliaccio, Agnese, Varrone, Francesca, Casalino, Laura, Matarazzo, Maria R, De Cesare, Dario, Scita, Giorgio, Patriarca, Eduardo J, Minchiotti, Gabriella
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Proliferation Cells, Cultured Collagen - metabolism Epigenesis, Genetic Epithelial-Mesenchymal Transition Female Gene Expression Regulation, Neoplastic Humans Hydroxylation Pluripotent Stem Cells - metabolism Pluripotent Stem Cells - pathology Prolyl Hydroxylases - genetics Prolyl Hydroxylases - metabolism
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