Structural and functional insights into phosphomannose isomerase: the role of zinc and catalytic residues

Phosphomannose isomerase (PMI) is a housekeeping enzyme that is found in organisms ranging from bacteria to fungi to mammals and is important for cell‐wall synthesis, viability and signalling. PMI is a zinc‐dependent enzyme that catalyses the reversible isomerization between mannose 6‐phosphate (M6P...

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Veröffentlicht in:	Acta crystallographica. Section D, Biological crystallography. Biological crystallography., 2019-05, Vol.75 (5), p.475-487
Hauptverfasser:	Bangera, Mamata, Gowda K, Giri, Sagurthi, S. R., Murthy, M. R. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Amino Acids - genetics Amino Acids - metabolism Antimicrobial agents Catalysis catalytic base Catalytic Domain Crystal structure Crystallography, X-Ray Enzymes Fructose Fructosephosphates - metabolism Fungi Isomerism Isomerization Mannose Mannose-6-Phosphate Isomerase - chemistry Mannose-6-Phosphate Isomerase - genetics Mannose-6-Phosphate Isomerase - metabolism Mannosephosphates - metabolism mechanism of isomerization Metal ions Models, Molecular Mutagenesis, Site-Directed Mutation phosphomannose isomerase Prokaryotes Protein Conformation Residues Ring opening Salmonella Salmonella typhimurium - enzymology Site-directed mutagenesis Structure-function relationships Substrate Specificity Substrates Viability Virulence Zinc Zinc - chemistry Zinc - metabolism zinc binding
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