Influence of prenatal waterpipe tobacco smoke exposure on reproductive hormones and oxidative stress of adult male offspring rats

Male infertility is adversely affected by tobacco cigarette smoking. Herein, the effects of prenatal waterpipe tobacco smoke (WTS) exposure on reproductive hormones and oxidative stress of adult offspring rats were evaluated. Pregnant rats received either fresh air or mainstream WTS (2 hr daily). Pr...

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Veröffentlicht in:	Andrologia 2019-09, Vol.51 (8), p.e13318-n/a
Hauptverfasser:	Al‐Sawalha, Nour A., Almahmmod, Yehya M., Alzoubi, Karem H., Khabour, Omar F., Alyacoub, Weam N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers Biomarkers - blood Biomarkers - metabolism Birth weight Catalase Cigarette smoking Disease Models, Animal Estrogens Estrogens - analysis Estrogens - metabolism Female Follicle-stimulating hormone Glutathione peroxidase Gonadotropins, Pituitary - blood Hormones Humans Infertility Infertility, Male - blood Infertility, Male - etiology Infertility, Male - pathology Luteinizing hormone Male Maternal Exposure - adverse effects Offspring Oxidative stress Oxidative Stress - drug effects oxidative stress biomarkers Pregnancy Prenatal experience prenatal exposure Prenatal Exposure Delayed Effects - blood Prenatal Exposure Delayed Effects - etiology Prenatal Exposure Delayed Effects - pathology Prolactin Rats Smoke Statistical analysis Superoxide dismutase Superoxide Dismutase - analysis Superoxide Dismutase - metabolism Testes Testis - pathology Testosterone Testosterone - analysis Testosterone - metabolism Thiobarbituric acid Thiobarbituric Acid Reactive Substances - analysis Thiobarbituric Acid Reactive Substances - metabolism Tobacco Tobacco smoke Tobacco Smoking - adverse effects Tobacco, Waterpipe - toxicity Water pipes waterpipe
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Beschreibung
Zusammenfassung:	Male infertility is adversely affected by tobacco cigarette smoking. Herein, the effects of prenatal waterpipe tobacco smoke (WTS) exposure on reproductive hormones and oxidative stress of adult offspring rats were evaluated. Pregnant rats received either fresh air or mainstream WTS (2 hr daily). Pregnancy outcomes, circulatory levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and prolactin, testicular levels of oestrogen, testosterone and oxidative stress biomarkers [catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx) and thiobarbituric acid reactive substances (TBARS)] were assessed in their adult male offspring rats. Prenatal WTS exposure reduced the number of born offspring, female to pups ratio and birthweight (p
ISSN:	0303-4569 1439-0272
DOI:	10.1111/and.13318