Pigment epithelium-derived factor peptide reverses mouse age-related meibomian gland atrophy

Age-related meibomian gland (MG) atrophy, characterized by decreased meibocyte proliferation, is one of the causes of meibomian gland dysfunction (MGD), which leads to dry eye disease. Currently, there is no available treatment effectively preventing or reversing the decreased cell proliferation and...

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Veröffentlicht in:	Experimental eye research 2019-08, Vol.185, p.107678-107678, Article 107678
Hauptverfasser:	Fan, Nai-Wen, Ho, Tsung-Chuan, Lin, Erh-Hsuan, Wu, Cheng-Wen, Chien, Hsin-Yu, Tsao, Yeou-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar atrophy Acinar Cells - drug effects Acinar Cells - metabolism Acinar Cells - pathology Aging Aging - physiology Animals Atrophy - drug therapy Atrophy - metabolism Atrophy - pathology Cell Proliferation - drug effects Conjunctiva - drug effects Dry eye disease Dry Eye Syndromes - drug therapy Dry Eye Syndromes - metabolism Dry Eye Syndromes - pathology Evaporative dry eye Eye Proteins - metabolism Eye Proteins - therapeutic use Female Fluorescent Antibody Technique, Indirect Immunohistochemistry Injections, Intraocular Meibomian gland dysfunction Meibomian glands Meibomian Glands - drug effects Meibomian Glands - metabolism Meibomian Glands - pathology Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Nerve Growth Factors - metabolism Nerve Growth Factors - therapeutic use Nerve Tissue Proteins - metabolism PEDF Regenerative medicine Serpins - metabolism Serpins - therapeutic use Tears - physiology Trans-Activators - metabolism
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