The Influence of the rs30461 Single Nucleotide Polymorphism on IFN-λ1 Activity and Secretion

Genetic variation within the loci is associated with several diseases and evidence indicates that the genes have been subjects of strong selection during recent human evolution. The nonsynonymous rs30461 single nucleotide polymorphism (SNP), generating interferon (IFN)-λ1 D188N, shows a strong signa...

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Veröffentlicht in:	Journal of interferon & cytokine research 2019-10, Vol.39 (10), p.661-667
Hauptverfasser:	Møhlenberg, Michelle, Gad, Hans Henrik, Hartmann, Rune
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological activity Biological evolution Evolutionary genetics Gene polymorphism Genetic diversity Hep G2 Cells Humans Interferon Interferons - genetics Interferons - metabolism Interleukins - genetics Interleukins - metabolism Nucleotides Periodontitis Polymorphism Polymorphism, Single Nucleotide Population genetics Population studies Positive selection Psoriasis Secretion Single-nucleotide polymorphism
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