Elevation of Lower Esophageal Sphincter Pressure With Acute Transcutaneous Electrical Acustimulation Synchronized With Inspiration
Background Gastroesophageal reflux disease (GERD) is a common esophageal disorder. Transcutaneous electrical acustimulation (TEA), as a needleless method of electroacupuncture (EA) has been reported to improve hypotensive lower esophageal sphincters pressure (LESP) in GERD. Synchronized TEA (STEA) w...
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| Veröffentlicht in: | Neuromodulation (Malden, Mass.) Mass.), 2019-07, Vol.22 (5), p.586-592 |
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| creator | Liu, Zhaoxiu Lu, Dewen Guo, Jie Liu, Yanmei Shi, Zhaohong Xu, Feng Lin, Lin Chen, Jiande D.Z. |
| description | Background
Gastroesophageal reflux disease (GERD) is a common esophageal disorder. Transcutaneous electrical acustimulation (TEA), as a needleless method of electroacupuncture (EA) has been reported to improve hypotensive lower esophageal sphincters pressure (LESP) in GERD. Synchronized TEA (STEA) with inspiration has been revealed to be more effective than TEA in enhancing vagal tone.
Aim
To explore the effect of STEA on LESP in GERD and possible mechanisms involving autonomic functions.
Methods
Sixty patients were randomly allocated into a STEA group (45 patients) and sham‐TEA group (15 patients). The ECG was recorded for the assessment of the autonomic function, followed with an esophageal high‐resolution manometry (HRM) test. When the test was completed, the STEA or sham‐TEA treatment was performed for 30 minutes. Then the HRM test was repeated.
Results
STEA increased LESP from 21.9 to 31.9 mmHg in GERD patients (p < 0.001). A negative correlation between the percentage of STEA‐induced increase in LESP and basal LESP was observed (R = −0.471, p = 0.001). STEA reduced the number of ineffective esophageal contractions (p < 0.05). STEA rather than sham‐TEA increased vagal activity (0.27 ± 0.14 vs. 0.36 ± 0.18, p < 0.001) and decreased sympathetic activity (0.73 ± 0.14 vs. 0.64 ± 0.18, p < 0.001).
Conclusions
Acute STEA augments LESP in GERD and the percentage of the increase in LESP was negatively correlated with basal LESP. The effect of STEA on LESP might be mediated via autonomic function.
Conflict of Interest
The authors reported no conflict of interest. |
| doi_str_mv | 10.1111/ner.12967 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2232118897</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2232118897</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3537-2452f24b4ce1e0f9eb9901b246e4bec46d5c27772aeeb5675724e9b379afc3603</originalsourceid><addsrcrecordid>eNp1kctKxDAUhoMo3he-gBTc6KKaazNZiowXGFS84LKkmVMn0klq0irj0ic3WnUhmE0OOV8-TvIjtEPwIUnryEE4JFQVcgmtE0FFTjhmy6nGiueSCLWGNmJ8wphIReUqWmOEsAILto7exw286M56l_k6m_hXCNk4-namH0E32W07s8506fA6QIx9gOzBdrPs2PQdZHdBu5gq7cD3MUsq0wVr0r3Uj52d982gvl04Mwve2TeYDoILF1sbvrpbaKXWTYTt730T3Z-O707O88nV2cXJ8SQ3TDCZUy5oTXnFDRDAtYJKKUwqygvgFRheTIWhUkqqASpRSCEpB1UxqXRt0mvZJtofvG3wzz3ErpzbaKBphvFLShklZDRSMqF7f9An3weXpkuUGMn0j1wl6mCgTPAxBqjLNti5DouS4PIzmDIFU34Fk9jdb2NfzWH6S_4kkYCjAXi1DSz-N5WX45tB-QH6iZmB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2258717949</pqid></control><display><type>article</type><title>Elevation of Lower Esophageal Sphincter Pressure With Acute Transcutaneous Electrical Acustimulation Synchronized With Inspiration</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Liu, Zhaoxiu ; Lu, Dewen ; Guo, Jie ; Liu, Yanmei ; Shi, Zhaohong ; Xu, Feng ; Lin, Lin ; Chen, Jiande D.Z.</creator><creatorcontrib>Liu, Zhaoxiu ; Lu, Dewen ; Guo, Jie ; Liu, Yanmei ; Shi, Zhaohong ; Xu, Feng ; Lin, Lin ; Chen, Jiande D.Z.</creatorcontrib><description>Background
Gastroesophageal reflux disease (GERD) is a common esophageal disorder. Transcutaneous electrical acustimulation (TEA), as a needleless method of electroacupuncture (EA) has been reported to improve hypotensive lower esophageal sphincters pressure (LESP) in GERD. Synchronized TEA (STEA) with inspiration has been revealed to be more effective than TEA in enhancing vagal tone.
Aim
To explore the effect of STEA on LESP in GERD and possible mechanisms involving autonomic functions.
Methods
Sixty patients were randomly allocated into a STEA group (45 patients) and sham‐TEA group (15 patients). The ECG was recorded for the assessment of the autonomic function, followed with an esophageal high‐resolution manometry (HRM) test. When the test was completed, the STEA or sham‐TEA treatment was performed for 30 minutes. Then the HRM test was repeated.
Results
STEA increased LESP from 21.9 to 31.9 mmHg in GERD patients (p < 0.001). A negative correlation between the percentage of STEA‐induced increase in LESP and basal LESP was observed (R = −0.471, p = 0.001). STEA reduced the number of ineffective esophageal contractions (p < 0.05). STEA rather than sham‐TEA increased vagal activity (0.27 ± 0.14 vs. 0.36 ± 0.18, p < 0.001) and decreased sympathetic activity (0.73 ± 0.14 vs. 0.64 ± 0.18, p < 0.001).
Conclusions
Acute STEA augments LESP in GERD and the percentage of the increase in LESP was negatively correlated with basal LESP. The effect of STEA on LESP might be mediated via autonomic function.
Conflict of Interest
The authors reported no conflict of interest.</description><identifier>ISSN: 1094-7159</identifier><identifier>EISSN: 1525-1403</identifier><identifier>DOI: 10.1111/ner.12967</identifier><identifier>PMID: 31136053</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Acupuncture ; Adult ; Aged ; Aged, 80 and over ; Autonomic nerve system ; Autonomic nervous system ; Conflicts of interest ; Electroacupuncture ; Esophageal sphincter ; Esophageal Sphincter, Lower - physiology ; Esophagus ; Female ; Gastroesophageal reflux ; Gastroesophageal Reflux - diagnosis ; Gastroesophageal Reflux - physiopathology ; Gastroesophageal Reflux - therapy ; gastroesophageal reflux disease ; high‐resolution manometry ; Humans ; Inhalation - physiology ; lower esophageal sphincters ; Male ; Manometry - methods ; Middle Aged ; Pilot Projects ; Pressure ; Single-Blind Method ; Sphincter ; synchronized transcutaneous electroacupuncture ; Transcutaneous Electric Nerve Stimulation - methods ; Vagus nerve</subject><ispartof>Neuromodulation (Malden, Mass.), 2019-07, Vol.22 (5), p.586-592</ispartof><rights>2019 International Neuromodulation Society</rights><rights>2019 International Neuromodulation Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3537-2452f24b4ce1e0f9eb9901b246e4bec46d5c27772aeeb5675724e9b379afc3603</citedby><cites>FETCH-LOGICAL-c3537-2452f24b4ce1e0f9eb9901b246e4bec46d5c27772aeeb5675724e9b379afc3603</cites><orcidid>0000-0003-0154-5232</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31136053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Zhaoxiu</creatorcontrib><creatorcontrib>Lu, Dewen</creatorcontrib><creatorcontrib>Guo, Jie</creatorcontrib><creatorcontrib>Liu, Yanmei</creatorcontrib><creatorcontrib>Shi, Zhaohong</creatorcontrib><creatorcontrib>Xu, Feng</creatorcontrib><creatorcontrib>Lin, Lin</creatorcontrib><creatorcontrib>Chen, Jiande D.Z.</creatorcontrib><title>Elevation of Lower Esophageal Sphincter Pressure With Acute Transcutaneous Electrical Acustimulation Synchronized With Inspiration</title><title>Neuromodulation (Malden, Mass.)</title><addtitle>Neuromodulation</addtitle><description>Background
Gastroesophageal reflux disease (GERD) is a common esophageal disorder. Transcutaneous electrical acustimulation (TEA), as a needleless method of electroacupuncture (EA) has been reported to improve hypotensive lower esophageal sphincters pressure (LESP) in GERD. Synchronized TEA (STEA) with inspiration has been revealed to be more effective than TEA in enhancing vagal tone.
Aim
To explore the effect of STEA on LESP in GERD and possible mechanisms involving autonomic functions.
Methods
Sixty patients were randomly allocated into a STEA group (45 patients) and sham‐TEA group (15 patients). The ECG was recorded for the assessment of the autonomic function, followed with an esophageal high‐resolution manometry (HRM) test. When the test was completed, the STEA or sham‐TEA treatment was performed for 30 minutes. Then the HRM test was repeated.
Results
STEA increased LESP from 21.9 to 31.9 mmHg in GERD patients (p < 0.001). A negative correlation between the percentage of STEA‐induced increase in LESP and basal LESP was observed (R = −0.471, p = 0.001). STEA reduced the number of ineffective esophageal contractions (p < 0.05). STEA rather than sham‐TEA increased vagal activity (0.27 ± 0.14 vs. 0.36 ± 0.18, p < 0.001) and decreased sympathetic activity (0.73 ± 0.14 vs. 0.64 ± 0.18, p < 0.001).
Conclusions
Acute STEA augments LESP in GERD and the percentage of the increase in LESP was negatively correlated with basal LESP. The effect of STEA on LESP might be mediated via autonomic function.
Conflict of Interest
The authors reported no conflict of interest.</description><subject>Acupuncture</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Autonomic nerve system</subject><subject>Autonomic nervous system</subject><subject>Conflicts of interest</subject><subject>Electroacupuncture</subject><subject>Esophageal sphincter</subject><subject>Esophageal Sphincter, Lower - physiology</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gastroesophageal reflux</subject><subject>Gastroesophageal Reflux - diagnosis</subject><subject>Gastroesophageal Reflux - physiopathology</subject><subject>Gastroesophageal Reflux - therapy</subject><subject>gastroesophageal reflux disease</subject><subject>high‐resolution manometry</subject><subject>Humans</subject><subject>Inhalation - physiology</subject><subject>lower esophageal sphincters</subject><subject>Male</subject><subject>Manometry - methods</subject><subject>Middle Aged</subject><subject>Pilot Projects</subject><subject>Pressure</subject><subject>Single-Blind Method</subject><subject>Sphincter</subject><subject>synchronized transcutaneous electroacupuncture</subject><subject>Transcutaneous Electric Nerve Stimulation - methods</subject><subject>Vagus nerve</subject><issn>1094-7159</issn><issn>1525-1403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctKxDAUhoMo3he-gBTc6KKaazNZiowXGFS84LKkmVMn0klq0irj0ic3WnUhmE0OOV8-TvIjtEPwIUnryEE4JFQVcgmtE0FFTjhmy6nGiueSCLWGNmJ8wphIReUqWmOEsAILto7exw286M56l_k6m_hXCNk4-namH0E32W07s8506fA6QIx9gOzBdrPs2PQdZHdBu5gq7cD3MUsq0wVr0r3Uj52d982gvl04Mwve2TeYDoILF1sbvrpbaKXWTYTt730T3Z-O707O88nV2cXJ8SQ3TDCZUy5oTXnFDRDAtYJKKUwqygvgFRheTIWhUkqqASpRSCEpB1UxqXRt0mvZJtofvG3wzz3ErpzbaKBphvFLShklZDRSMqF7f9An3weXpkuUGMn0j1wl6mCgTPAxBqjLNti5DouS4PIzmDIFU34Fk9jdb2NfzWH6S_4kkYCjAXi1DSz-N5WX45tB-QH6iZmB</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Liu, Zhaoxiu</creator><creator>Lu, Dewen</creator><creator>Guo, Jie</creator><creator>Liu, Yanmei</creator><creator>Shi, Zhaohong</creator><creator>Xu, Feng</creator><creator>Lin, Lin</creator><creator>Chen, Jiande D.Z.</creator><general>John Wiley & Sons, Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0154-5232</orcidid></search><sort><creationdate>201907</creationdate><title>Elevation of Lower Esophageal Sphincter Pressure With Acute Transcutaneous Electrical Acustimulation Synchronized With Inspiration</title><author>Liu, Zhaoxiu ; Lu, Dewen ; Guo, Jie ; Liu, Yanmei ; Shi, Zhaohong ; Xu, Feng ; Lin, Lin ; Chen, Jiande D.Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3537-2452f24b4ce1e0f9eb9901b246e4bec46d5c27772aeeb5675724e9b379afc3603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acupuncture</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Autonomic nerve system</topic><topic>Autonomic nervous system</topic><topic>Conflicts of interest</topic><topic>Electroacupuncture</topic><topic>Esophageal sphincter</topic><topic>Esophageal Sphincter, Lower - physiology</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gastroesophageal reflux</topic><topic>Gastroesophageal Reflux - diagnosis</topic><topic>Gastroesophageal Reflux - physiopathology</topic><topic>Gastroesophageal Reflux - therapy</topic><topic>gastroesophageal reflux disease</topic><topic>high‐resolution manometry</topic><topic>Humans</topic><topic>Inhalation - physiology</topic><topic>lower esophageal sphincters</topic><topic>Male</topic><topic>Manometry - methods</topic><topic>Middle Aged</topic><topic>Pilot Projects</topic><topic>Pressure</topic><topic>Single-Blind Method</topic><topic>Sphincter</topic><topic>synchronized transcutaneous electroacupuncture</topic><topic>Transcutaneous Electric Nerve Stimulation - methods</topic><topic>Vagus nerve</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Zhaoxiu</creatorcontrib><creatorcontrib>Lu, Dewen</creatorcontrib><creatorcontrib>Guo, Jie</creatorcontrib><creatorcontrib>Liu, Yanmei</creatorcontrib><creatorcontrib>Shi, Zhaohong</creatorcontrib><creatorcontrib>Xu, Feng</creatorcontrib><creatorcontrib>Lin, Lin</creatorcontrib><creatorcontrib>Chen, Jiande D.Z.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Neuromodulation (Malden, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Zhaoxiu</au><au>Lu, Dewen</au><au>Guo, Jie</au><au>Liu, Yanmei</au><au>Shi, Zhaohong</au><au>Xu, Feng</au><au>Lin, Lin</au><au>Chen, Jiande D.Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevation of Lower Esophageal Sphincter Pressure With Acute Transcutaneous Electrical Acustimulation Synchronized With Inspiration</atitle><jtitle>Neuromodulation (Malden, Mass.)</jtitle><addtitle>Neuromodulation</addtitle><date>2019-07</date><risdate>2019</risdate><volume>22</volume><issue>5</issue><spage>586</spage><epage>592</epage><pages>586-592</pages><issn>1094-7159</issn><eissn>1525-1403</eissn><abstract>Background
Gastroesophageal reflux disease (GERD) is a common esophageal disorder. Transcutaneous electrical acustimulation (TEA), as a needleless method of electroacupuncture (EA) has been reported to improve hypotensive lower esophageal sphincters pressure (LESP) in GERD. Synchronized TEA (STEA) with inspiration has been revealed to be more effective than TEA in enhancing vagal tone.
Aim
To explore the effect of STEA on LESP in GERD and possible mechanisms involving autonomic functions.
Methods
Sixty patients were randomly allocated into a STEA group (45 patients) and sham‐TEA group (15 patients). The ECG was recorded for the assessment of the autonomic function, followed with an esophageal high‐resolution manometry (HRM) test. When the test was completed, the STEA or sham‐TEA treatment was performed for 30 minutes. Then the HRM test was repeated.
Results
STEA increased LESP from 21.9 to 31.9 mmHg in GERD patients (p < 0.001). A negative correlation between the percentage of STEA‐induced increase in LESP and basal LESP was observed (R = −0.471, p = 0.001). STEA reduced the number of ineffective esophageal contractions (p < 0.05). STEA rather than sham‐TEA increased vagal activity (0.27 ± 0.14 vs. 0.36 ± 0.18, p < 0.001) and decreased sympathetic activity (0.73 ± 0.14 vs. 0.64 ± 0.18, p < 0.001).
Conclusions
Acute STEA augments LESP in GERD and the percentage of the increase in LESP was negatively correlated with basal LESP. The effect of STEA on LESP might be mediated via autonomic function.
Conflict of Interest
The authors reported no conflict of interest.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>31136053</pmid><doi>10.1111/ner.12967</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0154-5232</orcidid></addata></record> |
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| subjects | Acupuncture Adult Aged Aged, 80 and over Autonomic nerve system Autonomic nervous system Conflicts of interest Electroacupuncture Esophageal sphincter Esophageal Sphincter, Lower - physiology Esophagus Female Gastroesophageal reflux Gastroesophageal Reflux - diagnosis Gastroesophageal Reflux - physiopathology Gastroesophageal Reflux - therapy gastroesophageal reflux disease high‐resolution manometry Humans Inhalation - physiology lower esophageal sphincters Male Manometry - methods Middle Aged Pilot Projects Pressure Single-Blind Method Sphincter synchronized transcutaneous electroacupuncture Transcutaneous Electric Nerve Stimulation - methods Vagus nerve |
| title | Elevation of Lower Esophageal Sphincter Pressure With Acute Transcutaneous Electrical Acustimulation Synchronized With Inspiration |
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