Clinical significance of traditional clinical parameters and inflammatory biomarkers for the prognosis of patients with spinal chondrosarcoma: a retrospective study of 150 patients in a single center
Background To investigate the clinical significance of five inflammatory biomarkers and conventional clinical parameters in prognostic prediction of spinal chondrosarcoma. Methods Univariate and multivariate analyses were performed to investigate independent prognostic factors for recurrence and dea...
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| Veröffentlicht in: | European spine journal 2019-06, Vol.28 (6), p.1468-1479 |
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| creator | Xu, Kehan Li, Bo Huang, Quan Jiang, Dongjie Sun, Haitao Zhong, Nanzhe Wan, Wei Wei, Haifeng Xiao, Jianru |
| description | Background
To investigate the clinical significance of five inflammatory biomarkers and conventional clinical parameters in prognostic prediction of spinal chondrosarcoma.
Methods
Univariate and multivariate analyses were performed to investigate independent prognostic factors for recurrence and death of patients with spinal chondrosarcoma. Disease-free survival (DFS) and overall survival (OS) were estimated by Kaplan–Meier curve, and differences were analyzed by log-rank test. The optimal cutoff values for NLR, PLR, LMR, and CAR were determined by X-tile program.
Results
The optimal cutoff value for NLR, PLR, LMR, AGR, and CAR was 2.7, 200, 3.0, 1.5, and 0.2, respectively. Of the 150 patients included, recurrence was detected in 105 patients, and death occurred in 78 patients. Multivariate analysis indicated that Tomita I–III, total resection, and CAR |
| doi_str_mv | 10.1007/s00586-019-05993-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2232115867</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2219822087</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-1c0c3621afd4b83a3c24573ad1156c1a85f7cf4b5a05d04cf1ee2142b71236f33</originalsourceid><addsrcrecordid>eNp9kcmO1DAURS0EoouGH2CBLLFhE3ieMrBDJSapJTawjhznucpNYgfbAdUX8ls4Xd20xIKVh3vutZ4vIc8ZvGYAzZsEoNq6AtZVoLpOVPIB2TEpeAWd4A_JDjoJVd2w7oI8SekagKkO6sfkQjBQqq7ljvzeT847oyea3ME7W7beIA2W5qhHl13wRTN30KKjnjFjTFT7kTpvJz3POod4ooMLs47fN82GSPMR6RLDwYfk0ha46OzQ50R_uXykaXE3ycfgxxiSjqa431JNI-ZyXtBk9xNpyut42txMwX2C8wVMzh8mpKbcYHxKHlk9JXx2u16Sbx_ef91_qq6-fPy8f3dVGdGoXDEDRtScaTvKoRVaGC5VI_TImKoN062yjbFyUBrUCNJYhsiZ5EPDuKitEJfk1Tm3jPZjxZT72SWD06Q9hjX1nAtestq6KejLf9DrsMYy9EaxruUc2o3iZ8qUqVNE2y_RlX889Qz6reb-XHNfau5vau5lMb24jV6HGce_lrteCyDOQCqSP2C8f_s_sX8AD1m3Yg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2219822087</pqid></control><display><type>article</type><title>Clinical significance of traditional clinical parameters and inflammatory biomarkers for the prognosis of patients with spinal chondrosarcoma: a retrospective study of 150 patients in a single center</title><source>Springer journals</source><creator>Xu, Kehan ; Li, Bo ; Huang, Quan ; Jiang, Dongjie ; Sun, Haitao ; Zhong, Nanzhe ; Wan, Wei ; Wei, Haifeng ; Xiao, Jianru</creator><creatorcontrib>Xu, Kehan ; Li, Bo ; Huang, Quan ; Jiang, Dongjie ; Sun, Haitao ; Zhong, Nanzhe ; Wan, Wei ; Wei, Haifeng ; Xiao, Jianru</creatorcontrib><description>Background
To investigate the clinical significance of five inflammatory biomarkers and conventional clinical parameters in prognostic prediction of spinal chondrosarcoma.
Methods
Univariate and multivariate analyses were performed to investigate independent prognostic factors for recurrence and death of patients with spinal chondrosarcoma. Disease-free survival (DFS) and overall survival (OS) were estimated by Kaplan–Meier curve, and differences were analyzed by log-rank test. The optimal cutoff values for NLR, PLR, LMR, and CAR were determined by X-tile program.
Results
The optimal cutoff value for NLR, PLR, LMR, AGR, and CAR was 2.7, 200, 3.0, 1.5, and 0.2, respectively. Of the 150 patients included, recurrence was detected in 105 patients, and death occurred in 78 patients. Multivariate analysis indicated that Tomita I–III, total resection, and CAR < 0.2 were significantly associated with longer DFS. Meanwhile, preoperative Frankel score D–E, total resection, and CAR < 0.2 were favorable prognostic factors for OS. Subtype analysis showed that only total resection was an independent prognostic factor for DFS of recurrent spinal chondrosarcoma.
Conclusion
Total resection could significantly reduce the recurrence rate of spinal chondrosarcoma and improve OS of chondrosarcoma patients. Tomita classification I–III was a favorable factor for DFS, and preoperative Frankel score A–C was an adverse prognostic factor for OS. CAR was the most robust prognostic indicator with a discriminatory ability as compared with other inflammatory indicators.
Graphical abstract
These slides can be retrieved under Electronic Supplementary Material.</description><identifier>ISSN: 0940-6719</identifier><identifier>EISSN: 1432-0932</identifier><identifier>DOI: 10.1007/s00586-019-05993-4</identifier><identifier>PMID: 31055664</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biomarkers ; Chondrosarcoma ; Clinical significance ; Inflammation ; Medical prognosis ; Medicine ; Medicine & Public Health ; Multivariate analysis ; Neurosurgery ; Original Article ; Surgical Orthopedics ; Survival</subject><ispartof>European spine journal, 2019-06, Vol.28 (6), p.1468-1479</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>European Spine Journal is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-1c0c3621afd4b83a3c24573ad1156c1a85f7cf4b5a05d04cf1ee2142b71236f33</citedby><cites>FETCH-LOGICAL-c375t-1c0c3621afd4b83a3c24573ad1156c1a85f7cf4b5a05d04cf1ee2142b71236f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00586-019-05993-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00586-019-05993-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31055664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Kehan</creatorcontrib><creatorcontrib>Li, Bo</creatorcontrib><creatorcontrib>Huang, Quan</creatorcontrib><creatorcontrib>Jiang, Dongjie</creatorcontrib><creatorcontrib>Sun, Haitao</creatorcontrib><creatorcontrib>Zhong, Nanzhe</creatorcontrib><creatorcontrib>Wan, Wei</creatorcontrib><creatorcontrib>Wei, Haifeng</creatorcontrib><creatorcontrib>Xiao, Jianru</creatorcontrib><title>Clinical significance of traditional clinical parameters and inflammatory biomarkers for the prognosis of patients with spinal chondrosarcoma: a retrospective study of 150 patients in a single center</title><title>European spine journal</title><addtitle>Eur Spine J</addtitle><addtitle>Eur Spine J</addtitle><description>Background
To investigate the clinical significance of five inflammatory biomarkers and conventional clinical parameters in prognostic prediction of spinal chondrosarcoma.
Methods
Univariate and multivariate analyses were performed to investigate independent prognostic factors for recurrence and death of patients with spinal chondrosarcoma. Disease-free survival (DFS) and overall survival (OS) were estimated by Kaplan–Meier curve, and differences were analyzed by log-rank test. The optimal cutoff values for NLR, PLR, LMR, and CAR were determined by X-tile program.
Results
The optimal cutoff value for NLR, PLR, LMR, AGR, and CAR was 2.7, 200, 3.0, 1.5, and 0.2, respectively. Of the 150 patients included, recurrence was detected in 105 patients, and death occurred in 78 patients. Multivariate analysis indicated that Tomita I–III, total resection, and CAR < 0.2 were significantly associated with longer DFS. Meanwhile, preoperative Frankel score D–E, total resection, and CAR < 0.2 were favorable prognostic factors for OS. Subtype analysis showed that only total resection was an independent prognostic factor for DFS of recurrent spinal chondrosarcoma.
Conclusion
Total resection could significantly reduce the recurrence rate of spinal chondrosarcoma and improve OS of chondrosarcoma patients. Tomita classification I–III was a favorable factor for DFS, and preoperative Frankel score A–C was an adverse prognostic factor for OS. CAR was the most robust prognostic indicator with a discriminatory ability as compared with other inflammatory indicators.
Graphical abstract
These slides can be retrieved under Electronic Supplementary Material.</description><subject>Biomarkers</subject><subject>Chondrosarcoma</subject><subject>Clinical significance</subject><subject>Inflammation</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multivariate analysis</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>Surgical Orthopedics</subject><subject>Survival</subject><issn>0940-6719</issn><issn>1432-0932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kcmO1DAURS0EoouGH2CBLLFhE3ieMrBDJSapJTawjhznucpNYgfbAdUX8ls4Xd20xIKVh3vutZ4vIc8ZvGYAzZsEoNq6AtZVoLpOVPIB2TEpeAWd4A_JDjoJVd2w7oI8SekagKkO6sfkQjBQqq7ljvzeT847oyea3ME7W7beIA2W5qhHl13wRTN30KKjnjFjTFT7kTpvJz3POod4ooMLs47fN82GSPMR6RLDwYfk0ha46OzQ50R_uXykaXE3ycfgxxiSjqa431JNI-ZyXtBk9xNpyut42txMwX2C8wVMzh8mpKbcYHxKHlk9JXx2u16Sbx_ef91_qq6-fPy8f3dVGdGoXDEDRtScaTvKoRVaGC5VI_TImKoN062yjbFyUBrUCNJYhsiZ5EPDuKitEJfk1Tm3jPZjxZT72SWD06Q9hjX1nAtestq6KejLf9DrsMYy9EaxruUc2o3iZ8qUqVNE2y_RlX889Qz6reb-XHNfau5vau5lMb24jV6HGce_lrteCyDOQCqSP2C8f_s_sX8AD1m3Yg</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Xu, Kehan</creator><creator>Li, Bo</creator><creator>Huang, Quan</creator><creator>Jiang, Dongjie</creator><creator>Sun, Haitao</creator><creator>Zhong, Nanzhe</creator><creator>Wan, Wei</creator><creator>Wei, Haifeng</creator><creator>Xiao, Jianru</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190601</creationdate><title>Clinical significance of traditional clinical parameters and inflammatory biomarkers for the prognosis of patients with spinal chondrosarcoma: a retrospective study of 150 patients in a single center</title><author>Xu, Kehan ; Li, Bo ; Huang, Quan ; Jiang, Dongjie ; Sun, Haitao ; Zhong, Nanzhe ; Wan, Wei ; Wei, Haifeng ; Xiao, Jianru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-1c0c3621afd4b83a3c24573ad1156c1a85f7cf4b5a05d04cf1ee2142b71236f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Biomarkers</topic><topic>Chondrosarcoma</topic><topic>Clinical significance</topic><topic>Inflammation</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multivariate analysis</topic><topic>Neurosurgery</topic><topic>Original Article</topic><topic>Surgical Orthopedics</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Kehan</creatorcontrib><creatorcontrib>Li, Bo</creatorcontrib><creatorcontrib>Huang, Quan</creatorcontrib><creatorcontrib>Jiang, Dongjie</creatorcontrib><creatorcontrib>Sun, Haitao</creatorcontrib><creatorcontrib>Zhong, Nanzhe</creatorcontrib><creatorcontrib>Wan, Wei</creatorcontrib><creatorcontrib>Wei, Haifeng</creatorcontrib><creatorcontrib>Xiao, Jianru</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European spine journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Kehan</au><au>Li, Bo</au><au>Huang, Quan</au><au>Jiang, Dongjie</au><au>Sun, Haitao</au><au>Zhong, Nanzhe</au><au>Wan, Wei</au><au>Wei, Haifeng</au><au>Xiao, Jianru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of traditional clinical parameters and inflammatory biomarkers for the prognosis of patients with spinal chondrosarcoma: a retrospective study of 150 patients in a single center</atitle><jtitle>European spine journal</jtitle><stitle>Eur Spine J</stitle><addtitle>Eur Spine J</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>28</volume><issue>6</issue><spage>1468</spage><epage>1479</epage><pages>1468-1479</pages><issn>0940-6719</issn><eissn>1432-0932</eissn><abstract>Background
To investigate the clinical significance of five inflammatory biomarkers and conventional clinical parameters in prognostic prediction of spinal chondrosarcoma.
Methods
Univariate and multivariate analyses were performed to investigate independent prognostic factors for recurrence and death of patients with spinal chondrosarcoma. Disease-free survival (DFS) and overall survival (OS) were estimated by Kaplan–Meier curve, and differences were analyzed by log-rank test. The optimal cutoff values for NLR, PLR, LMR, and CAR were determined by X-tile program.
Results
The optimal cutoff value for NLR, PLR, LMR, AGR, and CAR was 2.7, 200, 3.0, 1.5, and 0.2, respectively. Of the 150 patients included, recurrence was detected in 105 patients, and death occurred in 78 patients. Multivariate analysis indicated that Tomita I–III, total resection, and CAR < 0.2 were significantly associated with longer DFS. Meanwhile, preoperative Frankel score D–E, total resection, and CAR < 0.2 were favorable prognostic factors for OS. Subtype analysis showed that only total resection was an independent prognostic factor for DFS of recurrent spinal chondrosarcoma.
Conclusion
Total resection could significantly reduce the recurrence rate of spinal chondrosarcoma and improve OS of chondrosarcoma patients. Tomita classification I–III was a favorable factor for DFS, and preoperative Frankel score A–C was an adverse prognostic factor for OS. CAR was the most robust prognostic indicator with a discriminatory ability as compared with other inflammatory indicators.
Graphical abstract
These slides can be retrieved under Electronic Supplementary Material.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31055664</pmid><doi>10.1007/s00586-019-05993-4</doi><tpages>12</tpages></addata></record> |
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| source | Springer journals |
| subjects | Biomarkers Chondrosarcoma Clinical significance Inflammation Medical prognosis Medicine Medicine & Public Health Multivariate analysis Neurosurgery Original Article Surgical Orthopedics Survival |
| title | Clinical significance of traditional clinical parameters and inflammatory biomarkers for the prognosis of patients with spinal chondrosarcoma: a retrospective study of 150 patients in a single center |
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