YKL-40 promotes the progress of atherosclerosis independent of lipid metabolism in apolipoprotein E−/− mice fed a high-fat diet

YKL-40 is recently regarded as a pro-inflammatory cytokine involved in the pathological process of atherosclerosis and lipid metabolism. However, whether YKL-40 can directly influence the development of atherosclerosis and levels of lipid parameters is unknown. The aim of this study is to explore th...

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Veröffentlicht in:	Heart and vessels 2019-11, Vol.34 (11), p.1874-1881
Hauptverfasser:	Chen, Lei, Zheng, Jianlei, Xue, Qi, Zhao, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Animals Aorta Apolipoprotein E Apolipoproteins Apolipoproteins E - blood Arteriosclerosis Atherosclerosis Atherosclerosis - blood Atherosclerosis - etiology Biomarkers Biomarkers - blood Biomedical Engineering and Bioengineering Cardiac Surgery Cardiology Cell adhesion Chitinase-3-Like Protein 1 - blood Cholesterol Collagen Diet Diet, High-Fat - adverse effects Disease Models, Animal Enzyme-Linked Immunosorbent Assay Fibers Gelatinase B High fat diet Immunohistochemistry Inflammation Interleukin 6 Interleukins Lipid metabolism Lipid Metabolism - physiology Lipids Macrophages Male Matrix metalloproteinase Matrix metalloproteinases Medicine Medicine & Public Health Metabolism Metalloproteinase Mice Mice, Inbred C57BL Mice, Knockout Muscles Oils & fats Original Article Parameters Plaques Serum levels Serum lipids Smooth muscle Triglycerides Tumor necrosis factor Tumor necrosis factor-TNF Tumors Vascular Surgery
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