Combining Constrained Heptapeptide Cassettes with Computational Design To Create Coiled-Coil Targeting Helical Peptides

A total of 32 heptapeptides have been synthesized and characterized to establish the effect of K → D (i → i + 4) lactamization upon their ability to adopt a helical conformation. Because most parallel and dimeric coiled-coil sequences can be deconvoluted into gabcdef repeats, we have introduced fixe...

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Veröffentlicht in:	ACS chemical biology 2019-06, Vol.14 (6), p.1293-1304
Hauptverfasser:	Lathbridge, Alexander, Mason, Jody M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Computational Biology Hydrophobic and Hydrophilic Interactions Oligopeptides - chemistry Protein Conformation Static Electricity
Online-Zugang:	Volltext
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