LncRNAs with miRNAs in regulation of gastric, liver, and colorectal cancers: updates in recent years
Long noncoding RNA (lncRNA) is a kind of RNAi molecule composed of hundreds to thousands of nucleotides. There are several major types of functional lncRNAs which participate in some important cellular pathways. LncRNA-RNA interaction controls mRNA translation and degradation or serves as a microRNA...
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| description | Long noncoding RNA (lncRNA) is a kind of RNAi molecule composed of hundreds to thousands of nucleotides. There are several major types of functional lncRNAs which participate in some important cellular pathways. LncRNA-RNA interaction controls mRNA translation and degradation or serves as a microRNA (miRNA) sponge for silencing. LncRNA-protein interaction regulates protein activity in transcriptional activation and silencing. LncRNA guide, decoy, and scaffold regulate transcription regulators of enhancer or repressor region of the coding genes for alteration of expression. LncRNA plays a role in cellular responses including the following activities: regulation of chromatin structural modification and gene expression for epigenetic and cell function control, promotion of hematopoiesis and maturation of immunity, cell programming in stem cell and somatic cell development, modulation of pathogen infection, switching glycolysis and lipid metabolism, and initiation of autoimmune diseases. LncRNA, together with miRNA, are considered the critical elements in cancer development. It has been demonstrated that tumorigenesis could be driven by homeostatic imbalance of lncRNA/miRNA/cancer regulatory factors resulting in biochemical and physiological alterations inside the cells. Cancer-driven lncRNAs with other cellular RNAs, epigenetic modulators, or protein effectors may change gene expression level and affect the viability, immortality, and motility of the cells that facilitate cancer cell cycle rearrangement, angiogenesis, proliferation, and metastasis. Molecular medicine will be the future trend for development. LncRNA/miRNA could be one of the potential candidates in this category. Continuous studies in lncRNA functional discrepancy between cancer cells and normal cells and regional and rational genetic differences of lncRNA profiles are critical for clinical research which is beneficial for clinical practice. |
| doi_str_mv | 10.1007/s00253-019-09837-5 |
| format | Article |
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It has been demonstrated that tumorigenesis could be driven by homeostatic imbalance of lncRNA/miRNA/cancer regulatory factors resulting in biochemical and physiological alterations inside the cells. Cancer-driven lncRNAs with other cellular RNAs, epigenetic modulators, or protein effectors may change gene expression level and affect the viability, immortality, and motility of the cells that facilitate cancer cell cycle rearrangement, angiogenesis, proliferation, and metastasis. Molecular medicine will be the future trend for development. LncRNA/miRNA could be one of the potential candidates in this category. Continuous studies in lncRNA functional discrepancy between cancer cells and normal cells and regional and rational genetic differences of lncRNA profiles are critical for clinical research which is beneficial for clinical practice.</description><identifier>ISSN: 0175-7598</identifier><identifier>EISSN: 1432-0614</identifier><identifier>DOI: 10.1007/s00253-019-09837-5</identifier><identifier>PMID: 31062053</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Angiogenesis ; Animals ; Autoimmune diseases ; Biomedical and Life Sciences ; Biotechnology ; Cancer ; Cell cycle ; Cell proliferation ; Cellular structure ; Chromatin ; Colorectal cancer ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - therapy ; Computational Biology ; Continuity (mathematics) ; Development and progression ; Epigenetics ; Gastric cancer ; Gene expression ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Gene silencing ; Genetic aspects ; Genetic regulation ; Glycolysis ; Health aspects ; Hematopoiesis ; Humans ; Immunity ; Life Sciences ; Lipid metabolism ; Lipids ; Liver cancer ; Liver Neoplasms - genetics ; Liver Neoplasms - therapy ; Metastases ; Mice ; Microbial Genetics and Genomics ; Microbiology ; MicroRNAs ; MicroRNAs - genetics ; Mini-Review ; miRNA ; Modulators ; Molecular Targeted Therapy ; Nucleotides ; Physiological effects ; Proteins ; Regulators ; Ribonucleic acid ; RNA ; RNA, Long Noncoding - genetics ; RNA-mediated interference ; Stem cells ; Stomach cancer ; Stomach Neoplasms - genetics ; Stomach Neoplasms - therapy ; Transcription activation ; Transcriptome ; Tumorigenesis ; Viability</subject><ispartof>Applied microbiology and biotechnology, 2019-06, Vol.103 (12), p.4649-4677</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Applied Microbiology and Biotechnology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-13e8b9f90fbcf2cd24fef25933f2edcb85dedc47e42752281537341709a4e9c03</citedby><cites>FETCH-LOGICAL-c513t-13e8b9f90fbcf2cd24fef25933f2edcb85dedc47e42752281537341709a4e9c03</cites><orcidid>0000-0001-7951-8838</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00253-019-09837-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00253-019-09837-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31062053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tam, Chit</creatorcontrib><creatorcontrib>Wong, Jack Ho</creatorcontrib><creatorcontrib>Tsui, Stephen Kwok Wing</creatorcontrib><creatorcontrib>Zuo, Tao</creatorcontrib><creatorcontrib>Chan, Ting Fung</creatorcontrib><creatorcontrib>Ng, Tzi Bun</creatorcontrib><title>LncRNAs with miRNAs in regulation of gastric, liver, and colorectal cancers: updates in recent years</title><title>Applied microbiology and biotechnology</title><addtitle>Appl Microbiol Biotechnol</addtitle><addtitle>Appl Microbiol Biotechnol</addtitle><description>Long noncoding RNA (lncRNA) is a kind of RNAi molecule composed of hundreds to thousands of nucleotides. There are several major types of functional lncRNAs which participate in some important cellular pathways. LncRNA-RNA interaction controls mRNA translation and degradation or serves as a microRNA (miRNA) sponge for silencing. LncRNA-protein interaction regulates protein activity in transcriptional activation and silencing. LncRNA guide, decoy, and scaffold regulate transcription regulators of enhancer or repressor region of the coding genes for alteration of expression. LncRNA plays a role in cellular responses including the following activities: regulation of chromatin structural modification and gene expression for epigenetic and cell function control, promotion of hematopoiesis and maturation of immunity, cell programming in stem cell and somatic cell development, modulation of pathogen infection, switching glycolysis and lipid metabolism, and initiation of autoimmune diseases. LncRNA, together with miRNA, are considered the critical elements in cancer development. It has been demonstrated that tumorigenesis could be driven by homeostatic imbalance of lncRNA/miRNA/cancer regulatory factors resulting in biochemical and physiological alterations inside the cells. Cancer-driven lncRNAs with other cellular RNAs, epigenetic modulators, or protein effectors may change gene expression level and affect the viability, immortality, and motility of the cells that facilitate cancer cell cycle rearrangement, angiogenesis, proliferation, and metastasis. Molecular medicine will be the future trend for development. LncRNA/miRNA could be one of the potential candidates in this category. Continuous studies in lncRNA functional discrepancy between cancer cells and normal cells and regional and rational genetic differences of lncRNA profiles are critical for clinical research which is beneficial for clinical practice.</description><subject>Angiogenesis</subject><subject>Animals</subject><subject>Autoimmune diseases</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Cancer</subject><subject>Cell cycle</subject><subject>Cell proliferation</subject><subject>Cellular structure</subject><subject>Chromatin</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - therapy</subject><subject>Computational Biology</subject><subject>Continuity (mathematics)</subject><subject>Development and progression</subject><subject>Epigenetics</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene Regulatory Networks</subject><subject>Gene silencing</subject><subject>Genetic aspects</subject><subject>Genetic regulation</subject><subject>Glycolysis</subject><subject>Health aspects</subject><subject>Hematopoiesis</subject><subject>Humans</subject><subject>Immunity</subject><subject>Life Sciences</subject><subject>Lipid metabolism</subject><subject>Lipids</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - therapy</subject><subject>Metastases</subject><subject>Mice</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>Mini-Review</subject><subject>miRNA</subject><subject>Modulators</subject><subject>Molecular Targeted Therapy</subject><subject>Nucleotides</subject><subject>Physiological effects</subject><subject>Proteins</subject><subject>Regulators</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA-mediated interference</subject><subject>Stem cells</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - therapy</subject><subject>Transcription activation</subject><subject>Transcriptome</subject><subject>Tumorigenesis</subject><subject>Viability</subject><issn>0175-7598</issn><issn>1432-0614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kl9rFDEUxYModq1-AR8k4ItCp-bPZGbi21K0LSwtVH0O2czNmDKTrEmmtd_etLtaVkTycEPyO4d7k4PQa0qOKSHth0QIE7wiVFZEdrytxBO0oDVnFWlo_RQtCG1F1QrZHaAXKV0TQlnXNM_RAaekYUTwBepX3lxdLBO-dfk7ntzD3nkcYZhHnV3wOFg86JSjM0d4dDcQj7D2PTZhDBFM1iM22huI6SOeN73OsDMw4DO-Ax3TS_TM6jHBq109RN8-f_p6clatLk_PT5arygjKc0U5dGtpJbFrY5npWW3BMiE5twx6s-5EX0rdQs1awVhHBW95TVsidQ3SEH6I3m19NzH8mCFlNblkYBy1hzAnxRhnlNStlAV9-xd6HeboS3eFKk9D64I9UoMeQTlvQ47a3JuqpegaySnnTaGO_0GV1cPkTPBgXTnfE7zfExQmw8886Dkldf7lap9lW9bEkFIEqzbRTTreKUrUfQzUNgaqxEA9xECJInqzm25eT9D_kfz-9wLwLZDKlR8gPo7_H9tfyYO5vA</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Tam, Chit</creator><creator>Wong, Jack Ho</creator><creator>Tsui, Stephen Kwok Wing</creator><creator>Zuo, Tao</creator><creator>Chan, Ting Fung</creator><creator>Ng, Tzi Bun</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>LK8</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7951-8838</orcidid></search><sort><creationdate>20190601</creationdate><title>LncRNAs with miRNAs in regulation of gastric, liver, and colorectal cancers: updates in recent years</title><author>Tam, Chit ; Wong, Jack Ho ; Tsui, Stephen Kwok Wing ; Zuo, Tao ; Chan, Ting Fung ; Ng, Tzi Bun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-13e8b9f90fbcf2cd24fef25933f2edcb85dedc47e42752281537341709a4e9c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Angiogenesis</topic><topic>Animals</topic><topic>Autoimmune diseases</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Cancer</topic><topic>Cell cycle</topic><topic>Cell proliferation</topic><topic>Cellular structure</topic><topic>Chromatin</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - 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It has been demonstrated that tumorigenesis could be driven by homeostatic imbalance of lncRNA/miRNA/cancer regulatory factors resulting in biochemical and physiological alterations inside the cells. Cancer-driven lncRNAs with other cellular RNAs, epigenetic modulators, or protein effectors may change gene expression level and affect the viability, immortality, and motility of the cells that facilitate cancer cell cycle rearrangement, angiogenesis, proliferation, and metastasis. Molecular medicine will be the future trend for development. LncRNA/miRNA could be one of the potential candidates in this category. 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| identifier | ISSN: 0175-7598 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Angiogenesis Animals Autoimmune diseases Biomedical and Life Sciences Biotechnology Cancer Cell cycle Cell proliferation Cellular structure Chromatin Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - therapy Computational Biology Continuity (mathematics) Development and progression Epigenetics Gastric cancer Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Regulatory Networks Gene silencing Genetic aspects Genetic regulation Glycolysis Health aspects Hematopoiesis Humans Immunity Life Sciences Lipid metabolism Lipids Liver cancer Liver Neoplasms - genetics Liver Neoplasms - therapy Metastases Mice Microbial Genetics and Genomics Microbiology MicroRNAs MicroRNAs - genetics Mini-Review miRNA Modulators Molecular Targeted Therapy Nucleotides Physiological effects Proteins Regulators Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA-mediated interference Stem cells Stomach cancer Stomach Neoplasms - genetics Stomach Neoplasms - therapy Transcription activation Transcriptome Tumorigenesis Viability |
| title | LncRNAs with miRNAs in regulation of gastric, liver, and colorectal cancers: updates in recent years |
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