Hippocampal PKR/NLRP1 Inflammasome Pathway Is Required for the Depression-Like Behaviors in Rats with Neuropathic Pain

The chronic neuropathic pain-associated psychiatric disorders have seriously disturbed the quality of patients' life, such as depression and anxiety. Neuroinflammation in the hippocampus plays an important role in the neuropathic pain-associated depressive and anxiety disorders, but the underly...

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Veröffentlicht in:	Neuroscience 2019-08, Vol.412, p.16-28
Hauptverfasser:	Li, Qian, Liu, Shenbin, Zhu, Xiaocang, Mi, Wenli, Maoying, Qiliang, Wang, Jun, Yu, Jin, Wang, Yanqing
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Aminopurine - pharmacology Animals anxiety Behavior, Animal - drug effects Behavior, Animal - physiology depression Depression - metabolism eIF-2 Kinase - metabolism hippocampus Hippocampus - drug effects Hippocampus - metabolism inflammasome Inflammasomes - metabolism Male Nerve Tissue Proteins - metabolism Neuralgia - etiology Neuralgia - metabolism Neurons - drug effects Neurons - metabolism pain Peripheral Nerve Injuries - complications Peripheral Nerve Injuries - metabolism PKR Rats Rats, Sprague-Dawley Sciatic Nerve - injuries Signal Transduction - drug effects Signal Transduction - physiology
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