Aerobic Exercise Improves Synaptic-Related Proteins of Diabetic Rats by Inhibiting FOXO1/NF-κB/NLRP3 Inflammatory Signaling Pathway and Ameliorating PI3K/Akt Insulin Signaling Pathway

Diabetes mellitus is metabolic syndrome and a risk factor for cognitive dysfunction-related diseases such as dementia, especially Alzheimer’s disease (AD), which is associated with chronic inflammation and abnormal insulin signaling pathway. Exercise, a known potential therapy for diabetes, can also...

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Veröffentlicht in:	Journal of molecular neuroscience 2019-09, Vol.69 (1), p.28-38
Hauptverfasser:	Wang, Qian, Hu, Jingyun, Liu, Yuran, Li, Jingjing, Liu, Beibei, Li, Mingming, Lou, Shujie
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Aerobics AKT protein Alzheimer's disease Animals Biomedical and Life Sciences Biomedicine Cell Biology Cognitive ability Dementia disorders Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Diet Exercise FOXO1 protein Health risks High fat diet Inflammation Insulin Insulin - metabolism Male Metabolic disorders Metabolic syndrome Nerve Tissue Proteins - metabolism Neurochemistry Neurodegeneration Neurology Neuronal Plasticity Neurosciences NF-kappa B - metabolism NF-κB protein NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Physical Conditioning, Animal Physical fitness Prefrontal cortex Prefrontal Cortex - metabolism Prefrontal Cortex - physiopathology Proteins Proteomics Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Risk analysis Risk factors Rodents Signal Transduction Signaling Synaptic plasticity Tau protein tau Proteins - metabolism
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