Cytotoxic Tigliane Diterpenoids from Croton damayeshu

Cytotoxic Tigliane Diterpenoids from Croton damayeshu

Chemical investigation of an EtOH extract of the twigs and leaves of Croton damayeshu afforded 10 new tigliane diterpenoids, crodamoids A–J (1–10), along with five known compounds. Their structures were elucidated by physical data analysis. Compounds 8, 9, and 15 displayed cytotoxic effects against...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2019-06, Vol.82 (6), p.1550-1557
Hauptverfasser: Cui, Jiao-Jiao, Ji, Kai-Long, Liu, Hong-Chun, Zhou, Bin, Liu, Qun-Fang, Xu, Cheng-Hui, Ding, Jian, Zhao, Jin-Xin, Yue, Jian-Min
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container_issue 6
container_start_page 1550
container_title Journal of natural products (Washington, D.C.)
container_volume 82
creator Cui, Jiao-Jiao
Ji, Kai-Long
Liu, Hong-Chun
Zhou, Bin
Liu, Qun-Fang
Xu, Cheng-Hui
Ding, Jian
Zhao, Jin-Xin
Yue, Jian-Min
description Chemical investigation of an EtOH extract of the twigs and leaves of Croton damayeshu afforded 10 new tigliane diterpenoids, crodamoids A–J (1–10), along with five known compounds. Their structures were elucidated by physical data analysis. Compounds 8, 9, and 15 displayed cytotoxic effects against two human tumor cell lines, A549 and HL-60 (IC50: 0.9–2.4 μM).
doi_str_mv 10.1021/acs.jnatprod.9b00042
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title Cytotoxic Tigliane Diterpenoids from Croton damayeshu
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