HMGA1 negatively regulates NUMB expression at transcriptional and post transcriptional level in glioblastoma stem cells

Glioblastoma (GBM) is a lethal, fast-growing brain cancer, affecting 2-3 per 100,000 adults per year. It arises from multipotent neural stem cells which have reduced their ability to divide asymmetrically and hence divide symmetrically, generating increasing number of cancer stem cells, fostering tu...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2019-07, Vol.18 (13), p.1446-1457
Hauptverfasser:	Puca, Francesca, Tosti, Nadia, Federico, Antonella, Kuzay, Yalçın, Pepe, Anna, Morlando, Sonia, Savarese, Teresa, D'Alessio, Federica, Colamaio, Marianna, Sarnataro, Daniela, Ziberi, Sihana, De Martino, Marco, Fusco, Alfredo, Battista, Sabrina
Format:	Artikel
Sprache:	eng
Schlagworte:	asymmetric division Brain - pathology Brain Neoplasms - genetics Brain Neoplasms - pathology cancer stem cells Cell Division - genetics Cell Line Cell Line, Tumor Down-Regulation - genetics Glioblastoma Glioblastoma - genetics Glioblastoma - pathology HEK293 Cells HMGA1 HMGA1a Protein - genetics Humans Membrane Proteins - genetics MicroRNAs - genetics Multipotent Stem Cells - pathology Neoplastic Stem Cells - pathology Nerve Tissue Proteins - genetics NOTCH1 NUMB Promoter Regions, Genetic - genetics Research Paper RNA Processing, Post-Transcriptional - genetics Transcription, Genetic - genetics
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