The synergistic effect of tobacco and alcohol consumption on oral squamous cell carcinoma: a systematic review and meta-analysis
Objectives This systematic review (SR) aimed to summarise and critically appraise available evidence about the association between the synergistic consumption of alcohol and tobacco and the occurrence of oral squamous cell carcinoma (OSCC). Materials and methods Observational studies investigating t...
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| Veröffentlicht in: | Clinical oral investigations 2019-07, Vol.23 (7), p.2849-2859 |
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| container_title | Clinical oral investigations |
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| creator | Mello, Fernanda Weber Melo, Gilberto Pasetto, Júlia Jacoby Silva, Carolina Amália Barcellos Warnakulasuriya, Saman Rivero, Elena Riet Correa |
| description | Objectives
This systematic review (SR) aimed to summarise and critically appraise available evidence about the association between the synergistic consumption of alcohol and tobacco and the occurrence of oral squamous cell carcinoma (OSCC).
Materials and methods
Observational studies investigating the association between the synergistic consumption of alcohol and tobacco and OSCC occurrence were included. Studies were selected in a two-phase process and searches were conducted on five main electronic databases, complemented by three grey literature databases.
Results
From 3260 records identified, 33 articles were included for qualitative analysis, of which 15 were included in the meta-analyses. Overall, the synergistic consumption was positively associated with the occurrence of OSCC (odds ratio [OR] = 5.37; 95% confidence interval [95%CI] = 3.54–8.14). Increased odds for OSCC occurrence were observed regarding the synergistic consumption of alcohol and smoked tobacco (OR = 4.74; 95%CI = 3.51–6.40), alcohol and smokeless tobacco (OR = 7.78; 95%CI = 2.86–21.14), and alcohol, smoked tobacco, and smokeless tobacco (OR = 16.17; 95%CI = 7.97–32.79).
Conclusions
According to the results of this SR, the synergistic consumption of alcohol and tobacco (both smoked and smokeless) significantly increased the odds for the occurrence of OSCC.
Clinical relevance
The knowledge provided by this SR may be useful for a better understanding of differences in the effect of synergistic consumption of alcohol and tobacco products in OSCC development. These data might aid healthcare authorities to develop measures for tobacco and alcohol control considering the needs of their population. |
| doi_str_mv | 10.1007/s00784-019-02958-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2232094171</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2227634131</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-4d778501b9460a52bfc40cd37df26ec871c62aa59a5efabda56af199d264fd493</originalsourceid><addsrcrecordid>eNp9kU1rFTEUhoMo9kP_gAsJuHETzdckE3dS1AoFN3UdzmSSdsrM5DZnxnJ3_nQz91YFF4aQE8hznhx4CXkl-DvBuX2P9Wg148IxLl3TMvGEnAqtDFPWiqeHu2TGteKEnCHecS60seo5OVGiLtnyU_Lz-jZS3M-x3Ay4DIHGlGJYaE50yR2EkCnMPYUx5Ns80pBnXKfdMuSZbrvASPF-hSmvSEMcKwElDHOe4AOFKsYlTrB5S_wxxIeDbIoLMJhh3OOAL8izBCPGl4_1nHz__On64pJdffvy9eLjFQvKNgvTvbVtw0XntOHQyC4FzUOvbJ-kiaG1IhgJ0DhoYoKuh8ZAEs710ujUa6fOydujd1fy_Rpx8dOA28Qwxzq8l1JJ7rSwoqJv_kHv8lrqvBslrVFaqI2SRyqUjFhi8rsyTFD2XnC_5eOP-fiajz_k47em14_qtZti_6fldyAVUEcA69N8E8vfv_-j_QXEspz6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2227634131</pqid></control><display><type>article</type><title>The synergistic effect of tobacco and alcohol consumption on oral squamous cell carcinoma: a systematic review and meta-analysis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Mello, Fernanda Weber ; Melo, Gilberto ; Pasetto, Júlia Jacoby ; Silva, Carolina Amália Barcellos ; Warnakulasuriya, Saman ; Rivero, Elena Riet Correa</creator><creatorcontrib>Mello, Fernanda Weber ; Melo, Gilberto ; Pasetto, Júlia Jacoby ; Silva, Carolina Amália Barcellos ; Warnakulasuriya, Saman ; Rivero, Elena Riet Correa</creatorcontrib><description>Objectives
This systematic review (SR) aimed to summarise and critically appraise available evidence about the association between the synergistic consumption of alcohol and tobacco and the occurrence of oral squamous cell carcinoma (OSCC).
Materials and methods
Observational studies investigating the association between the synergistic consumption of alcohol and tobacco and OSCC occurrence were included. Studies were selected in a two-phase process and searches were conducted on five main electronic databases, complemented by three grey literature databases.
Results
From 3260 records identified, 33 articles were included for qualitative analysis, of which 15 were included in the meta-analyses. Overall, the synergistic consumption was positively associated with the occurrence of OSCC (odds ratio [OR] = 5.37; 95% confidence interval [95%CI] = 3.54–8.14). Increased odds for OSCC occurrence were observed regarding the synergistic consumption of alcohol and smoked tobacco (OR = 4.74; 95%CI = 3.51–6.40), alcohol and smokeless tobacco (OR = 7.78; 95%CI = 2.86–21.14), and alcohol, smoked tobacco, and smokeless tobacco (OR = 16.17; 95%CI = 7.97–32.79).
Conclusions
According to the results of this SR, the synergistic consumption of alcohol and tobacco (both smoked and smokeless) significantly increased the odds for the occurrence of OSCC.
Clinical relevance
The knowledge provided by this SR may be useful for a better understanding of differences in the effect of synergistic consumption of alcohol and tobacco products in OSCC development. These data might aid healthcare authorities to develop measures for tobacco and alcohol control considering the needs of their population.</description><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-019-02958-1</identifier><identifier>PMID: 31111280</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Alcohol ; Alcohol Drinking - adverse effects ; Alcohol use ; Carcinoma, Squamous Cell - etiology ; Dentistry ; Humans ; Medicine ; Meta-analysis ; Mouth Neoplasms - etiology ; Oral cancer ; Oral squamous cell carcinoma ; Prospective Studies ; Retrospective Studies ; Review ; Risk Factors ; Smoking - adverse effects ; Squamous cell carcinoma ; Systematic review ; Tobacco ; Tobacco, Smokeless - adverse effects</subject><ispartof>Clinical oral investigations, 2019-07, Vol.23 (7), p.2849-2859</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>Clinical Oral Investigations is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-4d778501b9460a52bfc40cd37df26ec871c62aa59a5efabda56af199d264fd493</citedby><cites>FETCH-LOGICAL-c375t-4d778501b9460a52bfc40cd37df26ec871c62aa59a5efabda56af199d264fd493</cites><orcidid>0000-0002-2566-268X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-019-02958-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-019-02958-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31111280$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mello, Fernanda Weber</creatorcontrib><creatorcontrib>Melo, Gilberto</creatorcontrib><creatorcontrib>Pasetto, Júlia Jacoby</creatorcontrib><creatorcontrib>Silva, Carolina Amália Barcellos</creatorcontrib><creatorcontrib>Warnakulasuriya, Saman</creatorcontrib><creatorcontrib>Rivero, Elena Riet Correa</creatorcontrib><title>The synergistic effect of tobacco and alcohol consumption on oral squamous cell carcinoma: a systematic review and meta-analysis</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Objectives
This systematic review (SR) aimed to summarise and critically appraise available evidence about the association between the synergistic consumption of alcohol and tobacco and the occurrence of oral squamous cell carcinoma (OSCC).
Materials and methods
Observational studies investigating the association between the synergistic consumption of alcohol and tobacco and OSCC occurrence were included. Studies were selected in a two-phase process and searches were conducted on five main electronic databases, complemented by three grey literature databases.
Results
From 3260 records identified, 33 articles were included for qualitative analysis, of which 15 were included in the meta-analyses. Overall, the synergistic consumption was positively associated with the occurrence of OSCC (odds ratio [OR] = 5.37; 95% confidence interval [95%CI] = 3.54–8.14). Increased odds for OSCC occurrence were observed regarding the synergistic consumption of alcohol and smoked tobacco (OR = 4.74; 95%CI = 3.51–6.40), alcohol and smokeless tobacco (OR = 7.78; 95%CI = 2.86–21.14), and alcohol, smoked tobacco, and smokeless tobacco (OR = 16.17; 95%CI = 7.97–32.79).
Conclusions
According to the results of this SR, the synergistic consumption of alcohol and tobacco (both smoked and smokeless) significantly increased the odds for the occurrence of OSCC.
Clinical relevance
The knowledge provided by this SR may be useful for a better understanding of differences in the effect of synergistic consumption of alcohol and tobacco products in OSCC development. These data might aid healthcare authorities to develop measures for tobacco and alcohol control considering the needs of their population.</description><subject>Alcohol</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Alcohol use</subject><subject>Carcinoma, Squamous Cell - etiology</subject><subject>Dentistry</subject><subject>Humans</subject><subject>Medicine</subject><subject>Meta-analysis</subject><subject>Mouth Neoplasms - etiology</subject><subject>Oral cancer</subject><subject>Oral squamous cell carcinoma</subject><subject>Prospective Studies</subject><subject>Retrospective Studies</subject><subject>Review</subject><subject>Risk Factors</subject><subject>Smoking - adverse effects</subject><subject>Squamous cell carcinoma</subject><subject>Systematic review</subject><subject>Tobacco</subject><subject>Tobacco, Smokeless - adverse effects</subject><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1rFTEUhoMo9kP_gAsJuHETzdckE3dS1AoFN3UdzmSSdsrM5DZnxnJ3_nQz91YFF4aQE8hznhx4CXkl-DvBuX2P9Wg148IxLl3TMvGEnAqtDFPWiqeHu2TGteKEnCHecS60seo5OVGiLtnyU_Lz-jZS3M-x3Ay4DIHGlGJYaE50yR2EkCnMPYUx5Ns80pBnXKfdMuSZbrvASPF-hSmvSEMcKwElDHOe4AOFKsYlTrB5S_wxxIeDbIoLMJhh3OOAL8izBCPGl4_1nHz__On64pJdffvy9eLjFQvKNgvTvbVtw0XntOHQyC4FzUOvbJ-kiaG1IhgJ0DhoYoKuh8ZAEs710ujUa6fOydujd1fy_Rpx8dOA28Qwxzq8l1JJ7rSwoqJv_kHv8lrqvBslrVFaqI2SRyqUjFhi8rsyTFD2XnC_5eOP-fiajz_k47em14_qtZti_6fldyAVUEcA69N8E8vfv_-j_QXEspz6</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Mello, Fernanda Weber</creator><creator>Melo, Gilberto</creator><creator>Pasetto, Júlia Jacoby</creator><creator>Silva, Carolina Amália Barcellos</creator><creator>Warnakulasuriya, Saman</creator><creator>Rivero, Elena Riet Correa</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2566-268X</orcidid></search><sort><creationdate>20190701</creationdate><title>The synergistic effect of tobacco and alcohol consumption on oral squamous cell carcinoma: a systematic review and meta-analysis</title><author>Mello, Fernanda Weber ; Melo, Gilberto ; Pasetto, Júlia Jacoby ; Silva, Carolina Amália Barcellos ; Warnakulasuriya, Saman ; Rivero, Elena Riet Correa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-4d778501b9460a52bfc40cd37df26ec871c62aa59a5efabda56af199d264fd493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alcohol</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Alcohol use</topic><topic>Carcinoma, Squamous Cell - etiology</topic><topic>Dentistry</topic><topic>Humans</topic><topic>Medicine</topic><topic>Meta-analysis</topic><topic>Mouth Neoplasms - etiology</topic><topic>Oral cancer</topic><topic>Oral squamous cell carcinoma</topic><topic>Prospective Studies</topic><topic>Retrospective Studies</topic><topic>Review</topic><topic>Risk Factors</topic><topic>Smoking - adverse effects</topic><topic>Squamous cell carcinoma</topic><topic>Systematic review</topic><topic>Tobacco</topic><topic>Tobacco, Smokeless - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mello, Fernanda Weber</creatorcontrib><creatorcontrib>Melo, Gilberto</creatorcontrib><creatorcontrib>Pasetto, Júlia Jacoby</creatorcontrib><creatorcontrib>Silva, Carolina Amália Barcellos</creatorcontrib><creatorcontrib>Warnakulasuriya, Saman</creatorcontrib><creatorcontrib>Rivero, Elena Riet Correa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mello, Fernanda Weber</au><au>Melo, Gilberto</au><au>Pasetto, Júlia Jacoby</au><au>Silva, Carolina Amália Barcellos</au><au>Warnakulasuriya, Saman</au><au>Rivero, Elena Riet Correa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The synergistic effect of tobacco and alcohol consumption on oral squamous cell carcinoma: a systematic review and meta-analysis</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>23</volume><issue>7</issue><spage>2849</spage><epage>2859</epage><pages>2849-2859</pages><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Objectives
This systematic review (SR) aimed to summarise and critically appraise available evidence about the association between the synergistic consumption of alcohol and tobacco and the occurrence of oral squamous cell carcinoma (OSCC).
Materials and methods
Observational studies investigating the association between the synergistic consumption of alcohol and tobacco and OSCC occurrence were included. Studies were selected in a two-phase process and searches were conducted on five main electronic databases, complemented by three grey literature databases.
Results
From 3260 records identified, 33 articles were included for qualitative analysis, of which 15 were included in the meta-analyses. Overall, the synergistic consumption was positively associated with the occurrence of OSCC (odds ratio [OR] = 5.37; 95% confidence interval [95%CI] = 3.54–8.14). Increased odds for OSCC occurrence were observed regarding the synergistic consumption of alcohol and smoked tobacco (OR = 4.74; 95%CI = 3.51–6.40), alcohol and smokeless tobacco (OR = 7.78; 95%CI = 2.86–21.14), and alcohol, smoked tobacco, and smokeless tobacco (OR = 16.17; 95%CI = 7.97–32.79).
Conclusions
According to the results of this SR, the synergistic consumption of alcohol and tobacco (both smoked and smokeless) significantly increased the odds for the occurrence of OSCC.
Clinical relevance
The knowledge provided by this SR may be useful for a better understanding of differences in the effect of synergistic consumption of alcohol and tobacco products in OSCC development. These data might aid healthcare authorities to develop measures for tobacco and alcohol control considering the needs of their population.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31111280</pmid><doi>10.1007/s00784-019-02958-1</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2566-268X</orcidid></addata></record> |
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| ispartof | Clinical oral investigations, 2019-07, Vol.23 (7), p.2849-2859 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Alcohol Alcohol Drinking - adverse effects Alcohol use Carcinoma, Squamous Cell - etiology Dentistry Humans Medicine Meta-analysis Mouth Neoplasms - etiology Oral cancer Oral squamous cell carcinoma Prospective Studies Retrospective Studies Review Risk Factors Smoking - adverse effects Squamous cell carcinoma Systematic review Tobacco Tobacco, Smokeless - adverse effects |
| title | The synergistic effect of tobacco and alcohol consumption on oral squamous cell carcinoma: a systematic review and meta-analysis |
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