Transformation of follicular lymphoma to double-hit lymphoma during adjuvant chemotherapy for concurrent ovarian carcinoma
The frequency of multiple primary malignant neoplasms (MPMN) is increasing due to population aging. Since consensus guidelines for the treatment of MPMN are lacking, treatment strategies are determined by disease status on a per-patient basis. In this report, we describe a case of MPMN with follicul...
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| Veröffentlicht in: | International journal of hematology 2019-09, Vol.110 (3), p.375-380 |
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| container_title | International journal of hematology |
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| creator | Narazaki, Taisuke Nakashima, Yasuhiro Tsukamoto, Yasuhiro Tsuda, Mariko Masuda, Toru Kimura, Daisaku Takamatsu, Akiko Ohshima, Koichi Shiratsuchi, Motoaki Ogawa, Yoshihiro |
| description | The frequency of multiple primary malignant neoplasms (MPMN) is increasing due to population aging. Since consensus guidelines for the treatment of MPMN are lacking, treatment strategies are determined by disease status on a per-patient basis. In this report, we describe a case of MPMN with follicular lymphoma (FL) grade 1 that transformed to double-hit lymphoma during adjuvant chemotherapy for concurrent ovarian carcinoma. A 64-year-old woman was diagnosed with MPMN of FL and endometrioid carcinoma by staging laparotomy and lymph node biopsy. She received four cycles of adjuvant chemotherapy (carboplatin and paclitaxel) for endometrioid carcinoma, but during chemotherapy, the FL grade 1 transformed to double-hit lymphoma. We speculate that adjuvant chemotherapy for endometrioid carcinoma may have triggered the transformation of FL in the present case. |
| doi_str_mv | 10.1007/s12185-019-02656-4 |
| format | Article |
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Since consensus guidelines for the treatment of MPMN are lacking, treatment strategies are determined by disease status on a per-patient basis. In this report, we describe a case of MPMN with follicular lymphoma (FL) grade 1 that transformed to double-hit lymphoma during adjuvant chemotherapy for concurrent ovarian carcinoma. A 64-year-old woman was diagnosed with MPMN of FL and endometrioid carcinoma by staging laparotomy and lymph node biopsy. She received four cycles of adjuvant chemotherapy (carboplatin and paclitaxel) for endometrioid carcinoma, but during chemotherapy, the FL grade 1 transformed to double-hit lymphoma. We speculate that adjuvant chemotherapy for endometrioid carcinoma may have triggered the transformation of FL in the present case.</description><identifier>ISSN: 0925-5710</identifier><identifier>EISSN: 1865-3774</identifier><identifier>DOI: 10.1007/s12185-019-02656-4</identifier><identifier>PMID: 31104212</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Aging ; Antineoplastic Combined Chemotherapy Protocols - administration & dosage ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Biopsy ; Carboplatin ; Carboplatin - administration & dosage ; Carboplatin - adverse effects ; Carcinoma, Endometrioid - diagnostic imaging ; Carcinoma, Endometrioid - drug therapy ; Case Report ; Chemotherapy ; Chemotherapy, Adjuvant - adverse effects ; Endometrial cancer ; Female ; Hematology ; Humans ; Lymph nodes ; Lymphoma ; Lymphoma, Follicular - chemically induced ; Lymphoma, Follicular - diagnostic imaging ; Medical treatment ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasms ; Neoplasms, Second Primary - chemically induced ; Neoplasms, Second Primary - diagnostic imaging ; Oncology ; Ovarian cancer ; Ovarian carcinoma ; Ovarian Neoplasms - diagnostic imaging ; Ovarian Neoplasms - drug therapy ; Paclitaxel ; Paclitaxel - administration & dosage ; Paclitaxel - adverse effects</subject><ispartof>International journal of hematology, 2019-09, Vol.110 (3), p.375-380</ispartof><rights>Japanese Society of Hematology 2019</rights><rights>International Journal of Hematology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-66390fdeecde553bc0c513718760bb706eb2434abf55f002ee50beedc0dd7b683</citedby><cites>FETCH-LOGICAL-c399t-66390fdeecde553bc0c513718760bb706eb2434abf55f002ee50beedc0dd7b683</cites><orcidid>0000-0002-0403-0122</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12185-019-02656-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12185-019-02656-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31104212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Narazaki, Taisuke</creatorcontrib><creatorcontrib>Nakashima, Yasuhiro</creatorcontrib><creatorcontrib>Tsukamoto, Yasuhiro</creatorcontrib><creatorcontrib>Tsuda, Mariko</creatorcontrib><creatorcontrib>Masuda, Toru</creatorcontrib><creatorcontrib>Kimura, Daisaku</creatorcontrib><creatorcontrib>Takamatsu, Akiko</creatorcontrib><creatorcontrib>Ohshima, Koichi</creatorcontrib><creatorcontrib>Shiratsuchi, Motoaki</creatorcontrib><creatorcontrib>Ogawa, Yoshihiro</creatorcontrib><title>Transformation of follicular lymphoma to double-hit lymphoma during adjuvant chemotherapy for concurrent ovarian carcinoma</title><title>International journal of hematology</title><addtitle>Int J Hematol</addtitle><addtitle>Int J Hematol</addtitle><description>The frequency of multiple primary malignant neoplasms (MPMN) is increasing due to population aging. Since consensus guidelines for the treatment of MPMN are lacking, treatment strategies are determined by disease status on a per-patient basis. In this report, we describe a case of MPMN with follicular lymphoma (FL) grade 1 that transformed to double-hit lymphoma during adjuvant chemotherapy for concurrent ovarian carcinoma. A 64-year-old woman was diagnosed with MPMN of FL and endometrioid carcinoma by staging laparotomy and lymph node biopsy. She received four cycles of adjuvant chemotherapy (carboplatin and paclitaxel) for endometrioid carcinoma, but during chemotherapy, the FL grade 1 transformed to double-hit lymphoma. We speculate that adjuvant chemotherapy for endometrioid carcinoma may have triggered the transformation of FL in the present case.</description><subject>Aging</subject><subject>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Biopsy</subject><subject>Carboplatin</subject><subject>Carboplatin - administration & dosage</subject><subject>Carboplatin - adverse effects</subject><subject>Carcinoma, Endometrioid - diagnostic imaging</subject><subject>Carcinoma, Endometrioid - drug therapy</subject><subject>Case Report</subject><subject>Chemotherapy</subject><subject>Chemotherapy, Adjuvant - adverse effects</subject><subject>Endometrial cancer</subject><subject>Female</subject><subject>Hematology</subject><subject>Humans</subject><subject>Lymph nodes</subject><subject>Lymphoma</subject><subject>Lymphoma, Follicular - chemically induced</subject><subject>Lymphoma, Follicular - 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Academic</collection><jtitle>International journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Narazaki, Taisuke</au><au>Nakashima, Yasuhiro</au><au>Tsukamoto, Yasuhiro</au><au>Tsuda, Mariko</au><au>Masuda, Toru</au><au>Kimura, Daisaku</au><au>Takamatsu, Akiko</au><au>Ohshima, Koichi</au><au>Shiratsuchi, Motoaki</au><au>Ogawa, Yoshihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transformation of follicular lymphoma to double-hit lymphoma during adjuvant chemotherapy for concurrent ovarian carcinoma</atitle><jtitle>International journal of hematology</jtitle><stitle>Int J Hematol</stitle><addtitle>Int J Hematol</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>110</volume><issue>3</issue><spage>375</spage><epage>380</epage><pages>375-380</pages><issn>0925-5710</issn><eissn>1865-3774</eissn><abstract>The frequency of multiple primary malignant neoplasms (MPMN) is increasing due to population aging. Since consensus guidelines for the treatment of MPMN are lacking, treatment strategies are determined by disease status on a per-patient basis. In this report, we describe a case of MPMN with follicular lymphoma (FL) grade 1 that transformed to double-hit lymphoma during adjuvant chemotherapy for concurrent ovarian carcinoma. A 64-year-old woman was diagnosed with MPMN of FL and endometrioid carcinoma by staging laparotomy and lymph node biopsy. She received four cycles of adjuvant chemotherapy (carboplatin and paclitaxel) for endometrioid carcinoma, but during chemotherapy, the FL grade 1 transformed to double-hit lymphoma. We speculate that adjuvant chemotherapy for endometrioid carcinoma may have triggered the transformation of FL in the present case.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>31104212</pmid><doi>10.1007/s12185-019-02656-4</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-0403-0122</orcidid></addata></record> |
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| ispartof | International journal of hematology, 2019-09, Vol.110 (3), p.375-380 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Aging Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Biopsy Carboplatin Carboplatin - administration & dosage Carboplatin - adverse effects Carcinoma, Endometrioid - diagnostic imaging Carcinoma, Endometrioid - drug therapy Case Report Chemotherapy Chemotherapy, Adjuvant - adverse effects Endometrial cancer Female Hematology Humans Lymph nodes Lymphoma Lymphoma, Follicular - chemically induced Lymphoma, Follicular - diagnostic imaging Medical treatment Medicine Medicine & Public Health Middle Aged Neoplasms Neoplasms, Second Primary - chemically induced Neoplasms, Second Primary - diagnostic imaging Oncology Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - diagnostic imaging Ovarian Neoplasms - drug therapy Paclitaxel Paclitaxel - administration & dosage Paclitaxel - adverse effects |
| title | Transformation of follicular lymphoma to double-hit lymphoma during adjuvant chemotherapy for concurrent ovarian carcinoma |
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