The transcription factor FgMed1 is involved in early conidiogenesis and DON biosynthesis in the plant pathogenic fungus Fusarium graminearum
Fusarium graminearum is a prominent fungal pathogen that causes economically important losses by infesting a wide variety of cereal crops. F. graminearum produces both asexual and sexual spores which disseminate and inoculate hosts. Therefore, to better understand the disease cycle and to develop st...
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| Veröffentlicht in: | Applied microbiology and biotechnology 2019-07, Vol.103 (14), p.5851-5865 |
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| creator | Fan, Gaili Zhang, Kai Zhang, Jing Yang, Jie Yang, Xiaoshuang Hu, Yanpei Huang, Jiawei Zhu, Yangyan Yu, Wenying Hu, Hongli Wang, Baohua Shim, WonBo Lu, Guo-dong |
| description | Fusarium graminearum
is a prominent fungal pathogen that causes economically important losses by infesting a wide variety of cereal crops.
F. graminearum
produces both asexual and sexual spores which disseminate and inoculate hosts. Therefore, to better understand the disease cycle and to develop strategies to improve disease management, it is important to further clarify molecular mechanisms of
F. graminearum
conidiogenesis. In this study, we functionally characterized the
FgMed1
, a gene encoding an ortholog of a conserved
MedA
transcription factor known to be a key conidiogenesis regulator in
Aspergillus nidulans
. The gene deletion mutants
ΔFgMed1
produced significantly less conidia, and these were generated from abnormal conidiophores devoid of phialides. Additionally, we observed defective sexual development along with reduced virulence and deoxynivalenol (DON) production in
ΔFgMed1
. The GFP-tagged FgMed1 protein localized to the nuclei of conidiophores and phialides during early conidiogenesis. Significantly, RNA-Seq analyses showed that a number of the conidiation- and toxin-related genes are differentially expressed in the
ΔFgMed1
mutant in early conidiogenesis. These data strongly suggest that FgMed1 involved in regulation of genes associated with early conidiogenesis, DON production, and virulence in
F. graminearum
. |
| doi_str_mv | 10.1007/s00253-019-09872-2 |
| format | Article |
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is a prominent fungal pathogen that causes economically important losses by infesting a wide variety of cereal crops.
F. graminearum
produces both asexual and sexual spores which disseminate and inoculate hosts. Therefore, to better understand the disease cycle and to develop strategies to improve disease management, it is important to further clarify molecular mechanisms of
F. graminearum
conidiogenesis. In this study, we functionally characterized the
FgMed1
, a gene encoding an ortholog of a conserved
MedA
transcription factor known to be a key conidiogenesis regulator in
Aspergillus nidulans
. The gene deletion mutants
ΔFgMed1
produced significantly less conidia, and these were generated from abnormal conidiophores devoid of phialides. Additionally, we observed defective sexual development along with reduced virulence and deoxynivalenol (DON) production in
ΔFgMed1
. The GFP-tagged FgMed1 protein localized to the nuclei of conidiophores and phialides during early conidiogenesis. Significantly, RNA-Seq analyses showed that a number of the conidiation- and toxin-related genes are differentially expressed in the
ΔFgMed1
mutant in early conidiogenesis. These data strongly suggest that FgMed1 involved in regulation of genes associated with early conidiogenesis, DON production, and virulence in
F. graminearum
.</description><identifier>ISSN: 0175-7598</identifier><identifier>EISSN: 1432-0614</identifier><identifier>DOI: 10.1007/s00253-019-09872-2</identifier><identifier>PMID: 31115634</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analysis ; Applied Microbial and Cell Physiology ; Biomedical and Life Sciences ; Biosynthesis ; Biotechnology ; Biotechnology industry ; Cereal crops ; Conidia ; Deletion mutant ; Deoxynivalenol ; Disease control ; Economic importance ; Fungi ; Fusarium ; Fusarium graminearum ; Gene deletion ; Gene expression ; Gene regulation ; Genes ; Life Sciences ; Microbial Genetics and Genomics ; Microbiology ; Molecular modelling ; Neomycin ; Ribonucleic acid ; RNA ; RNA sequencing ; Spores ; Toxins ; Transcription factors ; Virulence</subject><ispartof>Applied microbiology and biotechnology, 2019-07, Vol.103 (14), p.5851-5865</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Applied Microbiology and Biotechnology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-c0bf5d462d3957151b2a6393ebf76c2eac368f5a9e99c4e775e7bf8d0b7d9f183</citedby><cites>FETCH-LOGICAL-c513t-c0bf5d462d3957151b2a6393ebf76c2eac368f5a9e99c4e775e7bf8d0b7d9f183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00253-019-09872-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00253-019-09872-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27906,27907,41470,42539,51301</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31115634$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fan, Gaili</creatorcontrib><creatorcontrib>Zhang, Kai</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Yang, Jie</creatorcontrib><creatorcontrib>Yang, Xiaoshuang</creatorcontrib><creatorcontrib>Hu, Yanpei</creatorcontrib><creatorcontrib>Huang, Jiawei</creatorcontrib><creatorcontrib>Zhu, Yangyan</creatorcontrib><creatorcontrib>Yu, Wenying</creatorcontrib><creatorcontrib>Hu, Hongli</creatorcontrib><creatorcontrib>Wang, Baohua</creatorcontrib><creatorcontrib>Shim, WonBo</creatorcontrib><creatorcontrib>Lu, Guo-dong</creatorcontrib><title>The transcription factor FgMed1 is involved in early conidiogenesis and DON biosynthesis in the plant pathogenic fungus Fusarium graminearum</title><title>Applied microbiology and biotechnology</title><addtitle>Appl Microbiol Biotechnol</addtitle><addtitle>Appl Microbiol Biotechnol</addtitle><description>Fusarium graminearum
is a prominent fungal pathogen that causes economically important losses by infesting a wide variety of cereal crops.
F. graminearum
produces both asexual and sexual spores which disseminate and inoculate hosts. Therefore, to better understand the disease cycle and to develop strategies to improve disease management, it is important to further clarify molecular mechanisms of
F. graminearum
conidiogenesis. In this study, we functionally characterized the
FgMed1
, a gene encoding an ortholog of a conserved
MedA
transcription factor known to be a key conidiogenesis regulator in
Aspergillus nidulans
. The gene deletion mutants
ΔFgMed1
produced significantly less conidia, and these were generated from abnormal conidiophores devoid of phialides. Additionally, we observed defective sexual development along with reduced virulence and deoxynivalenol (DON) production in
ΔFgMed1
. The GFP-tagged FgMed1 protein localized to the nuclei of conidiophores and phialides during early conidiogenesis. Significantly, RNA-Seq analyses showed that a number of the conidiation- and toxin-related genes are differentially expressed in the
ΔFgMed1
mutant in early conidiogenesis. These data strongly suggest that FgMed1 involved in regulation of genes associated with early conidiogenesis, DON production, and virulence in
F. graminearum
.</description><subject>Analysis</subject><subject>Applied Microbial and Cell Physiology</subject><subject>Biomedical and Life Sciences</subject><subject>Biosynthesis</subject><subject>Biotechnology</subject><subject>Biotechnology industry</subject><subject>Cereal crops</subject><subject>Conidia</subject><subject>Deletion mutant</subject><subject>Deoxynivalenol</subject><subject>Disease control</subject><subject>Economic importance</subject><subject>Fungi</subject><subject>Fusarium</subject><subject>Fusarium graminearum</subject><subject>Gene deletion</subject><subject>Gene expression</subject><subject>Gene regulation</subject><subject>Genes</subject><subject>Life Sciences</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>Molecular modelling</subject><subject>Neomycin</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA sequencing</subject><subject>Spores</subject><subject>Toxins</subject><subject>Transcription factors</subject><subject>Virulence</subject><issn>0175-7598</issn><issn>1432-0614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9ks1u1DAUhSMEokPhBVggS2xgkeKfOI6XVctApUIlKGvLca4zrhI72EnFvAMPjadTqAYh5IWt6-8c3Xt1iuIlwScEY_EuYUw5KzGRJZaNoCV9VKxIxWiJa1I9LlaYCF4KLpuj4llKNxgT2tT10-KIEUJ4zapV8fN6A2iO2icT3TS74JHVZg4RrftP0BHkEnL-Ngy30OUHAh2HLTLBu86FHjykDGjfofOrz6h1IW39vLkrZji_0DRoP6NJz5sd7gyyi--XhNZL0tEtI-qjHp3Pvsv4vHhi9ZDgxf19XHxbv78--1heXn24ODu9LA0nbC4Nbi3vqpp2THJBOGmprplk0FpRGwrasLqxXEuQ0lQgBAfR2qbDreikJQ07Lt7sfacYvi-QZjW6ZGDIrUJYkqKUUdw0WMiMvv4LvQlL9Lm7TNGmIriW_IHq9QDKeRvySs3OVJ1ySahoqNhRJ_-g8ulgdHmlYF2uHwjeHggyM8OPuddLSuri65dDlu5ZE0NKEayaoht13CqC1S4uah8XleOi7uKiaBa9up9uaUfo_kh-5yMDbA-k_OV7iA_j_8f2F717ymE</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Fan, 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transcription factor FgMed1 is involved in early conidiogenesis and DON biosynthesis in the plant pathogenic fungus Fusarium graminearum</title><author>Fan, Gaili ; Zhang, Kai ; Zhang, Jing ; Yang, Jie ; Yang, Xiaoshuang ; Hu, Yanpei ; Huang, Jiawei ; Zhu, Yangyan ; Yu, Wenying ; Hu, Hongli ; Wang, Baohua ; Shim, WonBo ; Lu, Guo-dong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-c0bf5d462d3957151b2a6393ebf76c2eac368f5a9e99c4e775e7bf8d0b7d9f183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Analysis</topic><topic>Applied Microbial and Cell Physiology</topic><topic>Biomedical and Life Sciences</topic><topic>Biosynthesis</topic><topic>Biotechnology</topic><topic>Biotechnology industry</topic><topic>Cereal crops</topic><topic>Conidia</topic><topic>Deletion mutant</topic><topic>Deoxynivalenol</topic><topic>Disease control</topic><topic>Economic importance</topic><topic>Fungi</topic><topic>Fusarium</topic><topic>Fusarium graminearum</topic><topic>Gene deletion</topic><topic>Gene expression</topic><topic>Gene regulation</topic><topic>Genes</topic><topic>Life Sciences</topic><topic>Microbial Genetics and Genomics</topic><topic>Microbiology</topic><topic>Molecular modelling</topic><topic>Neomycin</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA sequencing</topic><topic>Spores</topic><topic>Toxins</topic><topic>Transcription factors</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fan, Gaili</creatorcontrib><creatorcontrib>Zhang, Kai</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Yang, Jie</creatorcontrib><creatorcontrib>Yang, Xiaoshuang</creatorcontrib><creatorcontrib>Hu, Yanpei</creatorcontrib><creatorcontrib>Huang, Jiawei</creatorcontrib><creatorcontrib>Zhu, Yangyan</creatorcontrib><creatorcontrib>Yu, 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Guo-dong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The transcription factor FgMed1 is involved in early conidiogenesis and DON biosynthesis in the plant pathogenic fungus Fusarium graminearum</atitle><jtitle>Applied microbiology and biotechnology</jtitle><stitle>Appl Microbiol Biotechnol</stitle><addtitle>Appl Microbiol Biotechnol</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>103</volume><issue>14</issue><spage>5851</spage><epage>5865</epage><pages>5851-5865</pages><issn>0175-7598</issn><eissn>1432-0614</eissn><abstract>Fusarium graminearum
is a prominent fungal pathogen that causes economically important losses by infesting a wide variety of cereal crops.
F. graminearum
produces both asexual and sexual spores which disseminate and inoculate hosts. Therefore, to better understand the disease cycle and to develop strategies to improve disease management, it is important to further clarify molecular mechanisms of
F. graminearum
conidiogenesis. In this study, we functionally characterized the
FgMed1
, a gene encoding an ortholog of a conserved
MedA
transcription factor known to be a key conidiogenesis regulator in
Aspergillus nidulans
. The gene deletion mutants
ΔFgMed1
produced significantly less conidia, and these were generated from abnormal conidiophores devoid of phialides. Additionally, we observed defective sexual development along with reduced virulence and deoxynivalenol (DON) production in
ΔFgMed1
. The GFP-tagged FgMed1 protein localized to the nuclei of conidiophores and phialides during early conidiogenesis. Significantly, RNA-Seq analyses showed that a number of the conidiation- and toxin-related genes are differentially expressed in the
ΔFgMed1
mutant in early conidiogenesis. These data strongly suggest that FgMed1 involved in regulation of genes associated with early conidiogenesis, DON production, and virulence in
F. graminearum
.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31115634</pmid><doi>10.1007/s00253-019-09872-2</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0175-7598 |
| ispartof | Applied microbiology and biotechnology, 2019-07, Vol.103 (14), p.5851-5865 |
| issn | 0175-7598 1432-0614 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2232088079 |
| source | SpringerLink Journals |
| subjects | Analysis Applied Microbial and Cell Physiology Biomedical and Life Sciences Biosynthesis Biotechnology Biotechnology industry Cereal crops Conidia Deletion mutant Deoxynivalenol Disease control Economic importance Fungi Fusarium Fusarium graminearum Gene deletion Gene expression Gene regulation Genes Life Sciences Microbial Genetics and Genomics Microbiology Molecular modelling Neomycin Ribonucleic acid RNA RNA sequencing Spores Toxins Transcription factors Virulence |
| title | The transcription factor FgMed1 is involved in early conidiogenesis and DON biosynthesis in the plant pathogenic fungus Fusarium graminearum |
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