Effects of methionine partially replaced by methionyl‐methionine dipeptide on intestinal function in methionine‐deficient pregnant mice
This study was to compare the effects of parenteral supplementation of methionyl‐methionine (Met‐Met) or Met on intestinal barrier function in Met‐deficient pregnant mice. Pregnant mice were randomly divided into three groups. The Control group was provided a diet containing Met and received i.p. in...
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| Veröffentlicht in: | Journal of animal physiology and animal nutrition 2019-09, Vol.103 (5), p.1610-1618 |
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| container_title | Journal of animal physiology and animal nutrition |
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| creator | Chen, Qiong Wang, Caihong Zhao, Feng‐Qi Liu, Jianxin Liu, Hongyun |
| description | This study was to compare the effects of parenteral supplementation of methionyl‐methionine (Met‐Met) or Met on intestinal barrier function in Met‐deficient pregnant mice. Pregnant mice were randomly divided into three groups. The Control group was provided a diet containing Met and received i.p. injection of saline. The Met group was fed the same diet but without Met and received daily i.p. injection of 35% of the Met contained in the control diet. The Met‐Met group was treated the same as the Met group, except that 25% of the Met injected was replaced with Met‐Met. Met‐Met promoted villus surface area in ileum compared with Met alone. In addition, the mRNA abundance of amino acid and glucose transporters in the small intestine was altered with Met‐Met. Moreover, Met‐Met increased tight junction protein and decreased apoptosis‐related proteins expression in the jejunum and ileum. These results suggest that Met‐Met can promote intestinal function over Met alone in Met‐deficient mice. |
| doi_str_mv | 10.1111/jpn.13126 |
| format | Article |
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Pregnant mice were randomly divided into three groups. The Control group was provided a diet containing Met and received i.p. injection of saline. The Met group was fed the same diet but without Met and received daily i.p. injection of 35% of the Met contained in the control diet. The Met‐Met group was treated the same as the Met group, except that 25% of the Met injected was replaced with Met‐Met. Met‐Met promoted villus surface area in ileum compared with Met alone. In addition, the mRNA abundance of amino acid and glucose transporters in the small intestine was altered with Met‐Met. Moreover, Met‐Met increased tight junction protein and decreased apoptosis‐related proteins expression in the jejunum and ileum. These results suggest that Met‐Met can promote intestinal function over Met alone in Met‐deficient mice.</description><identifier>ISSN: 0931-2439</identifier><identifier>EISSN: 1439-0396</identifier><identifier>DOI: 10.1111/jpn.13126</identifier><identifier>PMID: 31106911</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Amino Acid Transport Systems ; Amino acids ; Animals ; Apoptosis ; Apoptosis - drug effects ; Apoptosis - physiology ; Diet ; Dietary supplements ; Dipeptides - administration & dosage ; Dipeptides - pharmacology ; Female ; Gene Expression Regulation - drug effects ; Glucose Transport Proteins, Facilitative - genetics ; Glucose Transport Proteins, Facilitative - metabolism ; Ileum ; Injection ; intestinal function ; Intestines - drug effects ; Jejunum ; Methionine ; Methionine - administration & dosage ; Methionine - deficiency ; Methionine - pharmacology ; methionyl‐methionine ; Mice ; mRNA ; Peptide Transporter 1 - genetics ; Peptide Transporter 1 - metabolism ; Pregnancy ; Proteins ; Random Allocation ; Rodents ; Small intestine ; tight junction ; Tight Junction Proteins - genetics ; Tight Junction Proteins - metabolism ; Villus</subject><ispartof>Journal of animal physiology and animal nutrition, 2019-09, Vol.103 (5), p.1610-1618</ispartof><rights>2019 Blackwell Verlag GmbH</rights><rights>2019 Blackwell Verlag GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-6d86b2f5b444973cb4684a74be8aa8bdf887f63f02bfd8c46c69e2315376416a3</citedby><cites>FETCH-LOGICAL-c3536-6d86b2f5b444973cb4684a74be8aa8bdf887f63f02bfd8c46c69e2315376416a3</cites><orcidid>0000-0001-8806-6204 ; 0000-0002-5812-5186</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjpn.13126$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjpn.13126$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31106911$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Qiong</creatorcontrib><creatorcontrib>Wang, Caihong</creatorcontrib><creatorcontrib>Zhao, Feng‐Qi</creatorcontrib><creatorcontrib>Liu, Jianxin</creatorcontrib><creatorcontrib>Liu, Hongyun</creatorcontrib><title>Effects of methionine partially replaced by methionyl‐methionine dipeptide on intestinal function in methionine‐deficient pregnant mice</title><title>Journal of animal physiology and animal nutrition</title><addtitle>J Anim Physiol Anim Nutr (Berl)</addtitle><description>This study was to compare the effects of parenteral supplementation of methionyl‐methionine (Met‐Met) or Met on intestinal barrier function in Met‐deficient pregnant mice. Pregnant mice were randomly divided into three groups. The Control group was provided a diet containing Met and received i.p. injection of saline. The Met group was fed the same diet but without Met and received daily i.p. injection of 35% of the Met contained in the control diet. The Met‐Met group was treated the same as the Met group, except that 25% of the Met injected was replaced with Met‐Met. Met‐Met promoted villus surface area in ileum compared with Met alone. In addition, the mRNA abundance of amino acid and glucose transporters in the small intestine was altered with Met‐Met. Moreover, Met‐Met increased tight junction protein and decreased apoptosis‐related proteins expression in the jejunum and ileum. These results suggest that Met‐Met can promote intestinal function over Met alone in Met‐deficient mice.</description><subject>Amino Acid Transport Systems</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - physiology</subject><subject>Diet</subject><subject>Dietary supplements</subject><subject>Dipeptides - administration & dosage</subject><subject>Dipeptides - pharmacology</subject><subject>Female</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Glucose Transport Proteins, Facilitative - genetics</subject><subject>Glucose Transport Proteins, Facilitative - metabolism</subject><subject>Ileum</subject><subject>Injection</subject><subject>intestinal function</subject><subject>Intestines - drug effects</subject><subject>Jejunum</subject><subject>Methionine</subject><subject>Methionine - administration & dosage</subject><subject>Methionine - deficiency</subject><subject>Methionine - pharmacology</subject><subject>methionyl‐methionine</subject><subject>Mice</subject><subject>mRNA</subject><subject>Peptide Transporter 1 - genetics</subject><subject>Peptide Transporter 1 - metabolism</subject><subject>Pregnancy</subject><subject>Proteins</subject><subject>Random Allocation</subject><subject>Rodents</subject><subject>Small intestine</subject><subject>tight junction</subject><subject>Tight Junction Proteins - genetics</subject><subject>Tight Junction Proteins - metabolism</subject><subject>Villus</subject><issn>0931-2439</issn><issn>1439-0396</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10bFO3TAUBmALgcrtbQdeAFlioUMuduw4zogQLUUIGOgcOc5x6yvHCXYilI29S5-xT4LhAkJIeLF19PmXrR-hPUpWNK2j9eBXlNFcbKEF5azKCKvENlqQitEsT4Nd9DnGNSG0LIj4hHYZpURUlC7Q31NjQI8R9wZ3MP6xvbce8KDCaJVzMw4wOKWhxc38Amb3__7fG9zaAYbRtoB7j60fIY7WK4fN5PVon2ZvstPdFozVFvyIhwC_vUqHzmr4gnaMchG-Pu9L9Ov76c3JWXZx9ePnyfFFplnBRCZaKZrcFA3nvCqZbriQXJW8AamUbFojZWkEMyRvTCs1F1pUkDNasFJwKhRbosNN7hD62ym9tu5s1OCc8tBPsc5zlhNZVCVN9OAdXfdTSJ97VLJKkVzKpL5tlA59jAFMPQTbqTDXlNSPDdWpofqpoWT3nxOnpoP2Vb5UksDRBtxZB_PHSfX59eUm8gHGM58D</recordid><startdate>201909</startdate><enddate>201909</enddate><creator>Chen, Qiong</creator><creator>Wang, Caihong</creator><creator>Zhao, Feng‐Qi</creator><creator>Liu, Jianxin</creator><creator>Liu, Hongyun</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8806-6204</orcidid><orcidid>https://orcid.org/0000-0002-5812-5186</orcidid></search><sort><creationdate>201909</creationdate><title>Effects of methionine partially replaced by methionyl‐methionine dipeptide on intestinal function in methionine‐deficient pregnant mice</title><author>Chen, Qiong ; Wang, Caihong ; Zhao, Feng‐Qi ; Liu, Jianxin ; Liu, Hongyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-6d86b2f5b444973cb4684a74be8aa8bdf887f63f02bfd8c46c69e2315376416a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Amino Acid Transport Systems</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - physiology</topic><topic>Diet</topic><topic>Dietary supplements</topic><topic>Dipeptides - administration & dosage</topic><topic>Dipeptides - pharmacology</topic><topic>Female</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Glucose Transport Proteins, Facilitative - genetics</topic><topic>Glucose Transport Proteins, Facilitative - metabolism</topic><topic>Ileum</topic><topic>Injection</topic><topic>intestinal function</topic><topic>Intestines - drug effects</topic><topic>Jejunum</topic><topic>Methionine</topic><topic>Methionine - administration & dosage</topic><topic>Methionine - deficiency</topic><topic>Methionine - pharmacology</topic><topic>methionyl‐methionine</topic><topic>Mice</topic><topic>mRNA</topic><topic>Peptide Transporter 1 - genetics</topic><topic>Peptide Transporter 1 - metabolism</topic><topic>Pregnancy</topic><topic>Proteins</topic><topic>Random Allocation</topic><topic>Rodents</topic><topic>Small intestine</topic><topic>tight junction</topic><topic>Tight Junction Proteins - genetics</topic><topic>Tight Junction Proteins - metabolism</topic><topic>Villus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Qiong</creatorcontrib><creatorcontrib>Wang, Caihong</creatorcontrib><creatorcontrib>Zhao, Feng‐Qi</creatorcontrib><creatorcontrib>Liu, Jianxin</creatorcontrib><creatorcontrib>Liu, Hongyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of animal physiology and animal nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Qiong</au><au>Wang, Caihong</au><au>Zhao, Feng‐Qi</au><au>Liu, Jianxin</au><au>Liu, Hongyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of methionine partially replaced by methionyl‐methionine dipeptide on intestinal function in methionine‐deficient pregnant mice</atitle><jtitle>Journal of animal physiology and animal nutrition</jtitle><addtitle>J Anim Physiol Anim Nutr (Berl)</addtitle><date>2019-09</date><risdate>2019</risdate><volume>103</volume><issue>5</issue><spage>1610</spage><epage>1618</epage><pages>1610-1618</pages><issn>0931-2439</issn><eissn>1439-0396</eissn><abstract>This study was to compare the effects of parenteral supplementation of methionyl‐methionine (Met‐Met) or Met on intestinal barrier function in Met‐deficient pregnant mice. Pregnant mice were randomly divided into three groups. The Control group was provided a diet containing Met and received i.p. injection of saline. The Met group was fed the same diet but without Met and received daily i.p. injection of 35% of the Met contained in the control diet. The Met‐Met group was treated the same as the Met group, except that 25% of the Met injected was replaced with Met‐Met. Met‐Met promoted villus surface area in ileum compared with Met alone. In addition, the mRNA abundance of amino acid and glucose transporters in the small intestine was altered with Met‐Met. Moreover, Met‐Met increased tight junction protein and decreased apoptosis‐related proteins expression in the jejunum and ileum. These results suggest that Met‐Met can promote intestinal function over Met alone in Met‐deficient mice.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31106911</pmid><doi>10.1111/jpn.13126</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8806-6204</orcidid><orcidid>https://orcid.org/0000-0002-5812-5186</orcidid></addata></record> |
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| subjects | Amino Acid Transport Systems Amino acids Animals Apoptosis Apoptosis - drug effects Apoptosis - physiology Diet Dietary supplements Dipeptides - administration & dosage Dipeptides - pharmacology Female Gene Expression Regulation - drug effects Glucose Transport Proteins, Facilitative - genetics Glucose Transport Proteins, Facilitative - metabolism Ileum Injection intestinal function Intestines - drug effects Jejunum Methionine Methionine - administration & dosage Methionine - deficiency Methionine - pharmacology methionyl‐methionine Mice mRNA Peptide Transporter 1 - genetics Peptide Transporter 1 - metabolism Pregnancy Proteins Random Allocation Rodents Small intestine tight junction Tight Junction Proteins - genetics Tight Junction Proteins - metabolism Villus |
| title | Effects of methionine partially replaced by methionyl‐methionine dipeptide on intestinal function in methionine‐deficient pregnant mice |
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