An on-chip model of protein paracellular and transcellular permeability in the microcirculation

Recent therapeutic success of large-molecule biologics has led to intense interest in assays to measure with precision their transport across the vascular endothelium and into the target tissue. Most current in vitro endothelial models show unrealistically large permeability coefficients due to a no...

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Veröffentlicht in:	Biomaterials 2019-08, Vol.212, p.115-125
Hauptverfasser:	Offeddu, Giovanni S., Haase, Kristina, Gillrie, Mark R., Li, Ran, Morozova, Olga, Hickman, Dean, Knutson, Charles G., Kamm, Roger D.
Format:	Artikel
Sprache:	eng
Schlagworte:	FcRn Microfluidics Organ-on-chip Permeability Trans-endothelial transport
Online-Zugang:	Volltext
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