The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency

Extracellular microparticles (MPs) can function as drug-delivery vehicles for anticancer drugs. Here, we show that the softness of MPs derived from tumour-repopulating cells (TRCs) isolated from three-dimensional fibrin gels enhances the MPs’ drug-delivery efficiency. We found that, compared with MP...

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Veröffentlicht in:	Nature biomedical engineering 2019-09, Vol.3 (9), p.729-740
Hauptverfasser:	Liang, Qingle, Bie, Nana, Yong, Tuying, Tang, Ke, Shi, Xiaolong, Wei, Zhaohan, Jia, Haibo, Zhang, Xiaoqiong, Zhao, Haiyan, Huang, Wei, Gan, Lu, Huang, Bo, Yang, Xiangliang
Format:	Artikel
Sprache:	eng
Schlagworte:	13/2 13/31 13/51 13/89 38/79 631/67/1059/99 631/67/71 639/166/988 639/925/352/152 64/116 64/60 692/4028/67/1059/99 96/34 96/35 Animals Antineoplastic Agents - pharmacology Antineoplastic drugs Antitumor agents Apoptosis Bioaccumulation Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Blood Vessels Cancer Cell culture Cell Line, Tumor Cell Survival Cell-Derived Microparticles - chemistry Cytoskeleton Disease Models, Animal Drug delivery Drug delivery systems Drug Delivery Systems - methods Drugs Efficiency Female Fibrin Gels Male Mechanical properties Mice Mice, Inbred BALB C Mice, Inbred C57BL Microparticles Parenchyma Parenchymal Tissue - blood supply Parenchymal Tissue - drug effects Phosphoproteins - metabolism RAW 264.7 Cells Softness Tissue culture Tumors Xenograft Model Antitumor Assays Xenografts Xenotransplantation
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