Sensitivity of a continuous hot-melt extrusion and strand pelletization line to control actions and composition variation

[Display omitted] The purpose of this work was to develop a robust hot-melt extrusion and strand pelletization process for manufacturing pellets with an immediate release (IR) of a poorly water-soluble active pharmaceutical ingredient (API), nimodipine. The robustness of pharmaceutical continuous ma...

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Veröffentlicht in:	International journal of pharmaceutics 2019-07, Vol.566, p.239-253
Hauptverfasser:	Hörmann, T.R., Rehrl, J., Scheibelhofer, O., Schaden, L.-M., Funke, A., Makert, C., Khinast, J.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Control strategy Design space Drug Compounding - methods Drug Liberation Hot Melt Extrusion Technology HPMC extrusion Hypromellose Derivatives - chemistry Melt pump Methylmethacrylates - chemistry Nimodipine - chemistry Pharmaceutical hot-melt extrusion Strand pelletization
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