The prognostic effect of known and newly detected type 2 diabetes in patients with acute coronary syndrome
Background: Dysglycemia is a well-established risk factor of coronary artery disease. Less is known of the prognostic effect of dysglycemia in acute coronary syndromes (ACSs). The aim of this study was to evaluate the long-term outcome of patients with ACSs according to glucometabolic categories. Me...
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| Veröffentlicht in: | European heart journal. Acute cardiovascular care 2020-09, Vol.9 (6), p.608-615 |
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| container_title | European heart journal. Acute cardiovascular care |
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| creator | Bjarnason, Thorarinn A Hafthorsson, Steinar O Kristinsdottir, Linda B Oskarsdottir, Erna S Johnsen, Arni Andersen, Karl |
| description | Background:
Dysglycemia is a well-established risk factor of coronary artery disease. Less is known of the prognostic effect of dysglycemia in acute coronary syndromes (ACSs). The aim of this study was to evaluate the long-term outcome of patients with ACSs according to glucometabolic categories.
Methods:
Patients with ACSs were consecutively included in the study. Among those with no previous history of type 2 diabetes (T2DM) glucose metabolism was evaluated with fasting glucose in plasma, glycated hemoglobin and a standard 2-h oral glucose tolerance test. Patients were classified having normal glucose metabolism, prediabetes, newly detected T2DM (nT2DM) and previously known T2DM (kT2DM). The clinical outcome parameters were death or myocardial infarction and other major adverse cardiac events (MACEs).
Results:
A total of 372 ACS patients (male 75.8%, 65.1 years (SD: 11.8)) constituted the study population. The proportion diagnosed with normal glucose metabolism, prediabetes, nT2DM and kT2DM was 20.7%, 46.5%, 6.2% and 26.6%, respectively. The mean follow-up period was 2.9 years. Patients with prediabetes, nT2DM and kT2DM had a hazard ratio of 5.8 (95% confidence interval (CI) 0.8–44.6), 10.9 (95% CI 1.2–98.3) and 14.9 (95% CI 2.0–113.7), respectively, for death/myocardial infarction and 1.4 (95% CI 0.6–3.1), 2.9 (95% CI 1.1–8.0) and 3.3 (95% CI 1.5–7.6), respectively, for a composite of MACEs.
Conclusion:
Patients with ACS and nT2DM or kT2DM were at increased risk of death/myocardial infarction and MACE compared with patients with normal glucose metabolism after approximately three years of follow-up. |
| doi_str_mv | 10.1177/2048872619849925 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2232074654</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_2048872619849925</sage_id><sourcerecordid>2232074654</sourcerecordid><originalsourceid>FETCH-LOGICAL-c379t-7f937d54546ba6ae756c0e44db5a8d00a1e757f2580aa43bbbf017871fbdac8f3</originalsourceid><addsrcrecordid>eNp1UE1rwzAMNWNjLV3vOw0fd8lmO07sHEfZFxR26c7BseU2XWt3sUPJv59Lux4GEwKJp6eH9BC6peSBUiEeGeFSClbSSvKqYsUFGh-gTIqcX557Vo7QNIQ1SSFIyWV-jUY5pUSkHKP1YgV41_ml8yG2GoO1oCP2Fn85v3dYOYMd7DcDNhDTBAyOww4ww6ZVTYICbh3eqdiCiwHv27jCSvcRsPadd6obcBic6fwWbtCVVZsA01OdoM-X58XsLZt_vL7PnuaZzkUVM2GrXJiCF7xsVKlAFKUmwLlpCiUNIYomSFhWSKIUz5umsYQKKahtjNLS5hN0f9RNb333EGK9bYOGzUY58H2oGcsZEbwseKKSI1V3PoQObL3r2m06uqakPphc_zU5rdyd1PtmC-a88GtpImRHQlBLqNe-71z69n_BHwf5hQc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2232074654</pqid></control><display><type>article</type><title>The prognostic effect of known and newly detected type 2 diabetes in patients with acute coronary syndrome</title><source>Access via SAGE</source><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Bjarnason, Thorarinn A ; Hafthorsson, Steinar O ; Kristinsdottir, Linda B ; Oskarsdottir, Erna S ; Johnsen, Arni ; Andersen, Karl</creator><creatorcontrib>Bjarnason, Thorarinn A ; Hafthorsson, Steinar O ; Kristinsdottir, Linda B ; Oskarsdottir, Erna S ; Johnsen, Arni ; Andersen, Karl</creatorcontrib><description>Background:
Dysglycemia is a well-established risk factor of coronary artery disease. Less is known of the prognostic effect of dysglycemia in acute coronary syndromes (ACSs). The aim of this study was to evaluate the long-term outcome of patients with ACSs according to glucometabolic categories.
Methods:
Patients with ACSs were consecutively included in the study. Among those with no previous history of type 2 diabetes (T2DM) glucose metabolism was evaluated with fasting glucose in plasma, glycated hemoglobin and a standard 2-h oral glucose tolerance test. Patients were classified having normal glucose metabolism, prediabetes, newly detected T2DM (nT2DM) and previously known T2DM (kT2DM). The clinical outcome parameters were death or myocardial infarction and other major adverse cardiac events (MACEs).
Results:
A total of 372 ACS patients (male 75.8%, 65.1 years (SD: 11.8)) constituted the study population. The proportion diagnosed with normal glucose metabolism, prediabetes, nT2DM and kT2DM was 20.7%, 46.5%, 6.2% and 26.6%, respectively. The mean follow-up period was 2.9 years. Patients with prediabetes, nT2DM and kT2DM had a hazard ratio of 5.8 (95% confidence interval (CI) 0.8–44.6), 10.9 (95% CI 1.2–98.3) and 14.9 (95% CI 2.0–113.7), respectively, for death/myocardial infarction and 1.4 (95% CI 0.6–3.1), 2.9 (95% CI 1.1–8.0) and 3.3 (95% CI 1.5–7.6), respectively, for a composite of MACEs.
Conclusion:
Patients with ACS and nT2DM or kT2DM were at increased risk of death/myocardial infarction and MACE compared with patients with normal glucose metabolism after approximately three years of follow-up.</description><identifier>ISSN: 2048-8726</identifier><identifier>EISSN: 2048-8734</identifier><identifier>DOI: 10.1177/2048872619849925</identifier><identifier>PMID: 31107107</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Acute Coronary Syndrome - complications ; Acute Coronary Syndrome - diagnosis ; Acute Coronary Syndrome - epidemiology ; Aged ; Blood Glucose - metabolism ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - diagnosis ; Female ; Follow-Up Studies ; Glucose Tolerance Test ; Humans ; Iceland - epidemiology ; Incidence ; Male ; Retrospective Studies ; Risk Assessment - methods ; Risk Factors</subject><ispartof>European heart journal. Acute cardiovascular care, 2020-09, Vol.9 (6), p.608-615</ispartof><rights>The European Society of Cardiology 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-7f937d54546ba6ae756c0e44db5a8d00a1e757f2580aa43bbbf017871fbdac8f3</citedby><cites>FETCH-LOGICAL-c379t-7f937d54546ba6ae756c0e44db5a8d00a1e757f2580aa43bbbf017871fbdac8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/2048872619849925$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/2048872619849925$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31107107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bjarnason, Thorarinn A</creatorcontrib><creatorcontrib>Hafthorsson, Steinar O</creatorcontrib><creatorcontrib>Kristinsdottir, Linda B</creatorcontrib><creatorcontrib>Oskarsdottir, Erna S</creatorcontrib><creatorcontrib>Johnsen, Arni</creatorcontrib><creatorcontrib>Andersen, Karl</creatorcontrib><title>The prognostic effect of known and newly detected type 2 diabetes in patients with acute coronary syndrome</title><title>European heart journal. Acute cardiovascular care</title><addtitle>Eur Heart J Acute Cardiovasc Care</addtitle><description>Background:
Dysglycemia is a well-established risk factor of coronary artery disease. Less is known of the prognostic effect of dysglycemia in acute coronary syndromes (ACSs). The aim of this study was to evaluate the long-term outcome of patients with ACSs according to glucometabolic categories.
Methods:
Patients with ACSs were consecutively included in the study. Among those with no previous history of type 2 diabetes (T2DM) glucose metabolism was evaluated with fasting glucose in plasma, glycated hemoglobin and a standard 2-h oral glucose tolerance test. Patients were classified having normal glucose metabolism, prediabetes, newly detected T2DM (nT2DM) and previously known T2DM (kT2DM). The clinical outcome parameters were death or myocardial infarction and other major adverse cardiac events (MACEs).
Results:
A total of 372 ACS patients (male 75.8%, 65.1 years (SD: 11.8)) constituted the study population. The proportion diagnosed with normal glucose metabolism, prediabetes, nT2DM and kT2DM was 20.7%, 46.5%, 6.2% and 26.6%, respectively. The mean follow-up period was 2.9 years. Patients with prediabetes, nT2DM and kT2DM had a hazard ratio of 5.8 (95% confidence interval (CI) 0.8–44.6), 10.9 (95% CI 1.2–98.3) and 14.9 (95% CI 2.0–113.7), respectively, for death/myocardial infarction and 1.4 (95% CI 0.6–3.1), 2.9 (95% CI 1.1–8.0) and 3.3 (95% CI 1.5–7.6), respectively, for a composite of MACEs.
Conclusion:
Patients with ACS and nT2DM or kT2DM were at increased risk of death/myocardial infarction and MACE compared with patients with normal glucose metabolism after approximately three years of follow-up.</description><subject>Acute Coronary Syndrome - complications</subject><subject>Acute Coronary Syndrome - diagnosis</subject><subject>Acute Coronary Syndrome - epidemiology</subject><subject>Aged</subject><subject>Blood Glucose - metabolism</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - diagnosis</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Iceland - epidemiology</subject><subject>Incidence</subject><subject>Male</subject><subject>Retrospective Studies</subject><subject>Risk Assessment - methods</subject><subject>Risk Factors</subject><issn>2048-8726</issn><issn>2048-8734</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UE1rwzAMNWNjLV3vOw0fd8lmO07sHEfZFxR26c7BseU2XWt3sUPJv59Lux4GEwKJp6eH9BC6peSBUiEeGeFSClbSSvKqYsUFGh-gTIqcX557Vo7QNIQ1SSFIyWV-jUY5pUSkHKP1YgV41_ml8yG2GoO1oCP2Fn85v3dYOYMd7DcDNhDTBAyOww4ww6ZVTYICbh3eqdiCiwHv27jCSvcRsPadd6obcBic6fwWbtCVVZsA01OdoM-X58XsLZt_vL7PnuaZzkUVM2GrXJiCF7xsVKlAFKUmwLlpCiUNIYomSFhWSKIUz5umsYQKKahtjNLS5hN0f9RNb333EGK9bYOGzUY58H2oGcsZEbwseKKSI1V3PoQObL3r2m06uqakPphc_zU5rdyd1PtmC-a88GtpImRHQlBLqNe-71z69n_BHwf5hQc</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Bjarnason, Thorarinn A</creator><creator>Hafthorsson, Steinar O</creator><creator>Kristinsdottir, Linda B</creator><creator>Oskarsdottir, Erna S</creator><creator>Johnsen, Arni</creator><creator>Andersen, Karl</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202009</creationdate><title>The prognostic effect of known and newly detected type 2 diabetes in patients with acute coronary syndrome</title><author>Bjarnason, Thorarinn A ; Hafthorsson, Steinar O ; Kristinsdottir, Linda B ; Oskarsdottir, Erna S ; Johnsen, Arni ; Andersen, Karl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-7f937d54546ba6ae756c0e44db5a8d00a1e757f2580aa43bbbf017871fbdac8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acute Coronary Syndrome - complications</topic><topic>Acute Coronary Syndrome - diagnosis</topic><topic>Acute Coronary Syndrome - epidemiology</topic><topic>Aged</topic><topic>Blood Glucose - metabolism</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - diagnosis</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Iceland - epidemiology</topic><topic>Incidence</topic><topic>Male</topic><topic>Retrospective Studies</topic><topic>Risk Assessment - methods</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bjarnason, Thorarinn A</creatorcontrib><creatorcontrib>Hafthorsson, Steinar O</creatorcontrib><creatorcontrib>Kristinsdottir, Linda B</creatorcontrib><creatorcontrib>Oskarsdottir, Erna S</creatorcontrib><creatorcontrib>Johnsen, Arni</creatorcontrib><creatorcontrib>Andersen, Karl</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal. Acute cardiovascular care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bjarnason, Thorarinn A</au><au>Hafthorsson, Steinar O</au><au>Kristinsdottir, Linda B</au><au>Oskarsdottir, Erna S</au><au>Johnsen, Arni</au><au>Andersen, Karl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prognostic effect of known and newly detected type 2 diabetes in patients with acute coronary syndrome</atitle><jtitle>European heart journal. Acute cardiovascular care</jtitle><addtitle>Eur Heart J Acute Cardiovasc Care</addtitle><date>2020-09</date><risdate>2020</risdate><volume>9</volume><issue>6</issue><spage>608</spage><epage>615</epage><pages>608-615</pages><issn>2048-8726</issn><eissn>2048-8734</eissn><abstract>Background:
Dysglycemia is a well-established risk factor of coronary artery disease. Less is known of the prognostic effect of dysglycemia in acute coronary syndromes (ACSs). The aim of this study was to evaluate the long-term outcome of patients with ACSs according to glucometabolic categories.
Methods:
Patients with ACSs were consecutively included in the study. Among those with no previous history of type 2 diabetes (T2DM) glucose metabolism was evaluated with fasting glucose in plasma, glycated hemoglobin and a standard 2-h oral glucose tolerance test. Patients were classified having normal glucose metabolism, prediabetes, newly detected T2DM (nT2DM) and previously known T2DM (kT2DM). The clinical outcome parameters were death or myocardial infarction and other major adverse cardiac events (MACEs).
Results:
A total of 372 ACS patients (male 75.8%, 65.1 years (SD: 11.8)) constituted the study population. The proportion diagnosed with normal glucose metabolism, prediabetes, nT2DM and kT2DM was 20.7%, 46.5%, 6.2% and 26.6%, respectively. The mean follow-up period was 2.9 years. Patients with prediabetes, nT2DM and kT2DM had a hazard ratio of 5.8 (95% confidence interval (CI) 0.8–44.6), 10.9 (95% CI 1.2–98.3) and 14.9 (95% CI 2.0–113.7), respectively, for death/myocardial infarction and 1.4 (95% CI 0.6–3.1), 2.9 (95% CI 1.1–8.0) and 3.3 (95% CI 1.5–7.6), respectively, for a composite of MACEs.
Conclusion:
Patients with ACS and nT2DM or kT2DM were at increased risk of death/myocardial infarction and MACE compared with patients with normal glucose metabolism after approximately three years of follow-up.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>31107107</pmid><doi>10.1177/2048872619849925</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European heart journal. Acute cardiovascular care, 2020-09, Vol.9 (6), p.608-615 |
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| source | Access via SAGE; MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Acute Coronary Syndrome - complications Acute Coronary Syndrome - diagnosis Acute Coronary Syndrome - epidemiology Aged Blood Glucose - metabolism Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - diagnosis Female Follow-Up Studies Glucose Tolerance Test Humans Iceland - epidemiology Incidence Male Retrospective Studies Risk Assessment - methods Risk Factors |
| title | The prognostic effect of known and newly detected type 2 diabetes in patients with acute coronary syndrome |
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