Characterization of a Schistosoma mansoni NDPK expressed in sexual and digestive organs

•Crystallographic structure of nucleoside diphosphate kinase (NDPK) from Schistosoma mansoni in two different space-group and in complex with ADP.•Kinetics characterization of ATP-dependence for binding and activation of SmNDPK.•Relation with the oviposition and digestive processes showed by in situ...

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Veröffentlicht in:	Molecular and biochemical parasitology 2019-07, Vol.231, p.111187-111187, Article 111187
Hauptverfasser:	Torini, Juliana Roberta, de Freitas Fernandes, Adriano, Balasco Serrão, Vitor Hugo, Romanello, Larissa, Bird, Louise E., Nettleship, Joanne E., Owens, Raymond J., Brandão-Neto, José, Zeraik, Ana Eliza, DeMarco, Ricardo, D’Muniz Pereira, Humberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - chemistry Adenosine Diphosphate - metabolism Adenosine Triphosphate - chemistry Adenosine Triphosphate - metabolism Amino Acid Sequence Animals Catalytic Domain Crystallography Esophagus - chemistry Esophagus - enzymology Female Gastrointestinal Tract - chemistry Gastrointestinal Tract - enzymology Helminth Proteins - chemistry Helminth Proteins - genetics Helminth Proteins - metabolism Humans Isothermal titration calorimetry Kinetics Male Models, Molecular NDPK Nucleoside-Diphosphate Kinase - chemistry Nucleoside-Diphosphate Kinase - genetics Nucleoside-Diphosphate Kinase - metabolism Schistosoma mansoni Schistosoma mansoni - enzymology Schistosoma mansoni - genetics Schistosoma mansoni - metabolism Schistosomiasis mansoni - parasitology Sequence Alignment
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