Theoretical Model for the Structural Relaxation Time in Coamorphous Drugs

We propose a simple approach to investigate the structural relaxation time and glass transition of amorphous drugs. Amorphous materials are modeled as a set of equal sized hard spheres. The structural relaxation time over many decades in hard-sphere fluids is theoretically calculated using the elast...

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Veröffentlicht in:	Molecular pharmaceutics 2019-07, Vol.16 (7), p.2992-2998
Hauptverfasser:	Phan, Anh D, Knapik-Kowalczuk, Justyna, Paluch, Marian, Hoang, Trinh X, Wakabayashi, Katsunori
Format:	Artikel
Sprache:	eng
Schlagworte:	Calorimetry, Differential Scanning Dielectric Spectroscopy Drug Compounding - methods Drug Liberation Ezetimibe - chemistry Kinetics Models, Molecular Pyrrolidines - chemistry Simvastatin - chemistry Solubility Temperature Vinyl Compounds - chemistry Vitrification
Online-Zugang:	Volltext
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