Targeted drug delivery to the brain via intranasal nanoemulsion: Available proof of concept and existing challenges

[Display omitted] Intranasal delivery has shown to circumvent blood-brain-barrier (BBB) and deliver the drugs into the CNS at a higher rate and extent than other conventional routes. The mechanism of drug transport from nose-to-brain is not fully understood yet, but several neuronal pathways are con...

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Veröffentlicht in:	International journal of pharmaceutics 2019-06, Vol.565, p.258-268
Hauptverfasser:	Chatterjee, Bappaditya, Gorain, Bapi, Mohananaidu, Keithanchali, Sengupta, Pinaki, Mandal, Uttam Kumar, Choudhury, Hira
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Brain - metabolism Drug Delivery Systems Emulsions Humans In situ gel Intranasal Mucoadhesive nanoemulsion Nanoemulgel Nanoemulsion Nanoparticles - administration & dosage Nasal Mucosa - metabolism Nose to brain
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