Quorum‐sensing system in Acinetobacter baumannii: a potential target for new drug development

Acinetobacter baumannii causes several nosocomial infections and poses major threat when it is multidrug resistant. Even pan drug‐resistant strains have been reported in some countries. The intensive care unit (ICU) mortality rate ranged from 45.6% to 60.9% and it is as high as 84.3% when ventilator...

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Veröffentlicht in:	Journal of applied microbiology 2020-01, Vol.128 (1), p.15-27
Hauptverfasser:	Saipriya, K., Swathi, C.H., Ratnakar, K.S., Sritharan, V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinetobacter baumannii Acinetobacter baumannii - drug effects Acinetobacter baumannii - pathogenicity Acinetobacter baumannii - physiology Acinetobacter Infections - drug therapy Acinetobacter Infections - microbiology acyl homoserine lactones Acyl-Butyrolactones - metabolism Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotics Bacteria Bacterial Proteins - metabolism biofilm Biofilms Biofilms - drug effects Biofilms - growth & development Cell division DNA biosynthesis Drug Development Drug resistance Drug Resistance, Multiple, Bacterial - drug effects Drug Resistance, Multiple, Bacterial - genetics Gram-negative bacteria Multidrug resistance Nosocomial infection Nosocomial infections quorum quenching Quorum sensing Quorum Sensing - drug effects Resistance factors Synthesis Virulence Virulence factors Virulence Factors - metabolism
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