Impact of specific inhibitors on metallo-β-carbapenemases detected in Escherichia coli and Klebsiella pneumoniae isolates

Carbapenems are widely regarded as the drugs of choice for the treatment of severe infections caused by extended-spectrum beta lactamases producing Enterobacteriaceae. The emergence of carbapenem-resistant organisms is worrisome due to the limited treatment options. Detection of carbapenemase-produc...

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Veröffentlicht in:	Microbial pathogenesis 2019-07, Vol.132, p.266-274
Hauptverfasser:	Abbas, Hisham A., Kadry, Ashraf A., Shaker, Ghada H., Goda, Reham M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Ascorbic Acid - antagonists & inhibitors Bacterial Proteins - drug effects Bacterial Proteins - genetics beta-Lactamases - drug effects beta-Lactamases - genetics Carbapenem-Resistant Enterobacteriaceae - drug effects Carbapenems - pharmacology Catalytic Domain - drug effects Ciprofloxacin - antagonists & inhibitors Citric Acid - antagonists & inhibitors Drug Combinations Drug Synergism Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - isolation & purification Humans Imipenem - pharmacology Inhibition Klebsiella pneumonia Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Malates - antagonists & inhibitors Meropenem - pharmacology Metallo-β-carbapenemases Microbial Sensitivity Tests Zinc
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