Activation of NFKB-JMJD3 signaling promotes bladder fibrosis via boosting bladder smooth muscle cell proliferation and collagen accumulation

Chronic cystitis is characterized by the hyperplasia and fibrosis of the bladder wall as well as attenuated compliance of the bladder. To further unravel its underlying molecular mechanism, the role of NFκB-JMJD3 signaling pathway in cystitis induced bladder fibrosis was investigated. Jmjd3 and Col1...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2019-09, Vol.1865 (9), p.2403-2410
Hauptverfasser:	Lai, Junyu, Ge, Manqing, Shen, Sikui, Yang, Lu, Jin, Tao, Cao, Dehong, Xu, Hang, Zheng, Xiaonan, Qiu, Shi, Wang, Kunjie, Wei, Qiang, Li, Hong, Ai, Jianzhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzazepines - pharmacology Bladder fibrosis Cell Proliferation - drug effects Chronic fibrosis Collagen - genetics Collagen - metabolism Cystitis - chemically induced Cystitis - pathology Disease Models, Animal Female Fibrosis hBSMCs Humans JMJD3 Jumonji Domain-Containing Histone Demethylases - genetics Jumonji Domain-Containing Histone Demethylases - metabolism Lipopolysaccharides - pharmacology Mice Mice, Inbred C57BL Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - metabolism NF-kappa B - metabolism NFκB Phenylenediamines - pharmacology Pyrimidines - pharmacology Signal Transduction - drug effects Up-Regulation - drug effects Urinary Bladder - cytology Urinary Bladder - metabolism
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