Chiral β-lactam-based integrin ligands through Lipase-catalysed kinetic resolution and their enantioselective receptor response

[Display omitted] •Kinetic resolution of azetidinones by Lipases.•Burkholderia cepacia lipase promoted the resolution in transesterification.•Synthesis of enantiopure β-lactams targeting integrins α4β1 and α5β1.•Enantiospecific response of (S)-azetidinones in promoting cell adhesion. Obtainment and...

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Veröffentlicht in:	Bioorganic chemistry 2019-07, Vol.88, p.102975-102975, Article 102975
Hauptverfasser:	Martelli, Giulia, Galletti, Paola, Baiula, Monica, Calcinari, Luca, Boschi, Giacomo, Giacomini, Daria
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Azetidinones Biocatalysis Cell adhesion Integrins Kinetic resolution Lactams
Online-Zugang:	Volltext
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