XEN implant device versus trabeculectomy, either alone or in combination with phacoemulsification, in open-angle glaucoma patients
Purpose To compare the efficacy and safety of the XEN45 implant with that of trabeculectomy (TRAB), either alone or in combination with phacoemulsification (PHACO), in patients with open-angle glaucoma (OAG). Methods Retrospective, single-center and comparative study conducted on OAG patients. Patie...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2019-08, Vol.257 (8), p.1741-1750 |
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| creator | Marcos Parra, María Teresa Salinas López, Javier Alejandro López Grau, Noelia Soledad Ceausescu, Ana María Pérez Santonja, Juan José |
| description | Purpose
To compare the efficacy and safety of the XEN45 implant with that of trabeculectomy (TRAB), either alone or in combination with phacoemulsification (PHACO), in patients with open-angle glaucoma (OAG).
Methods
Retrospective, single-center and comparative study conducted on OAG patients. Patients were divided into four groups: group 1 (XEN alone); group 2 (XEN+PHACO); group 3 (TRAB alone); group 4 (TRAB+PHACO). For statistical purposes, groups 1 and 2 were combined (XEN implant), while groups 3 and 4 were also combined (TRAB surgery). The main outcome measure was intraocular pressure (IOP).
Results
Ninety-one patients (121 eyes; 65 XEN and 56 TRAB) were included. IOP reduction was − 6.7 (− 10.4 to − 3.0) mmHg,
p
= 0.0013; − 3.5 (− 5.0 to − 2.0) mmHg,
p
|
| doi_str_mv | 10.1007/s00417-019-04341-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2232036384</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2225493005</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-859ea4a401f96edc68da95b88dd05db7d8d4630b65ae412270b6bd7fc8bfaff03</originalsourceid><addsrcrecordid>eNp9kUtv1TAQhS0EopfCH2CBLLFh0cD4kThZoqo8pKrdFOnuLMee3LpK7GAnre6WX47bW0Bi0dVYOt85M9Yh5C2DjwxAfcoAkqkKWFeBFJJV-2dkw6SoKwV8-5xsQHFWtYJvj8irnG-g8KJmL8mRYNAJ1TQb8mt7dkH9NI8mLNThrbdIbzHlNdMlmR7tOqJd4rQ_oeiXa0zUjDEgjYn6QG2ceh_M4mOgd0Wm87WxEad1zH7w9kE4uQfjjKEyYTci3Y1mLT5D5yJjWPJr8mIwY8Y3j_OY_PhydnX6rTq__Pr99PN5ZYWql6qtOzTSSGBD16CzTetMV_dt6xzUrleudbIR0De1Qck4V-XZOzXYth_MMIA4Jh8OuXOKP1fMi558tjiWr2Ncs-ZccBCNaGVB3_-H3sQ1hXJdoXgtOwFQF4ofKJtizgkHPSc_mbTXDPR9Q_rQkC4N6YeG9L6Y3j1Gr_2E7q_lTyUFEAcgFynsMP3b_UTsb8w0nz4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2225493005</pqid></control><display><type>article</type><title>XEN implant device versus trabeculectomy, either alone or in combination with phacoemulsification, in open-angle glaucoma patients</title><source>SpringerLink Journals - AutoHoldings</source><creator>Marcos Parra, María Teresa ; Salinas López, Javier Alejandro ; López Grau, Noelia Soledad ; Ceausescu, Ana María ; Pérez Santonja, Juan José</creator><creatorcontrib>Marcos Parra, María Teresa ; Salinas López, Javier Alejandro ; López Grau, Noelia Soledad ; Ceausescu, Ana María ; Pérez Santonja, Juan José</creatorcontrib><description>Purpose
To compare the efficacy and safety of the XEN45 implant with that of trabeculectomy (TRAB), either alone or in combination with phacoemulsification (PHACO), in patients with open-angle glaucoma (OAG).
Methods
Retrospective, single-center and comparative study conducted on OAG patients. Patients were divided into four groups: group 1 (XEN alone); group 2 (XEN+PHACO); group 3 (TRAB alone); group 4 (TRAB+PHACO). For statistical purposes, groups 1 and 2 were combined (XEN implant), while groups 3 and 4 were also combined (TRAB surgery). The main outcome measure was intraocular pressure (IOP).
Results
Ninety-one patients (121 eyes; 65 XEN and 56 TRAB) were included. IOP reduction was − 6.7 (− 10.4 to − 3.0) mmHg,
p
= 0.0013; − 3.5 (− 5.0 to − 2.0) mmHg,
p
< 0.0001; − 8.1 (− 10.4 to − 5.9) mmHg,
p
< 0.0001l; and − 7.3 (− 9.3 to − 5.3) mmHg,
p
< 0.0001 in the XEN alone, XEN+PHACO, TRAB alone, and TRAB+PHACO, respectively. At month 12, an IOP ≥ 6 and ≤ 16 mm without treatment was achieved by 44 (67.7%) and 43 (76.8%),
p
= 0.2687 in the XEN implant and the TRAB surgery groups, respectively. The mean number of antiglaucoma medications was significantly reduced in all the study groups (
p
< 0.0001 each). Needling occurred in 20.0% (13/65) of eyes in the XEN implant group, while hyphema occurred in 30.4% (17/56) of eyes in the TRAB group.
Conclusions
XEN implant, either alone or in combination with phacoemulsification, significantly reduces both IOP and the number of antiglaucoma medications to a similar rate than trabeculectomy, but with a better safety profile.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-019-04341-y</identifier><identifier>PMID: 31093766</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Eye ; Glaucoma ; Medicine ; Medicine & Public Health ; Ophthalmology ; Patients ; Surgery</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2019-08, Vol.257 (8), p.1741-1750</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>Graefe's Archive for Clinical and Experimental Ophthalmology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-859ea4a401f96edc68da95b88dd05db7d8d4630b65ae412270b6bd7fc8bfaff03</citedby><cites>FETCH-LOGICAL-c375t-859ea4a401f96edc68da95b88dd05db7d8d4630b65ae412270b6bd7fc8bfaff03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-019-04341-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-019-04341-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31093766$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marcos Parra, María Teresa</creatorcontrib><creatorcontrib>Salinas López, Javier Alejandro</creatorcontrib><creatorcontrib>López Grau, Noelia Soledad</creatorcontrib><creatorcontrib>Ceausescu, Ana María</creatorcontrib><creatorcontrib>Pérez Santonja, Juan José</creatorcontrib><title>XEN implant device versus trabeculectomy, either alone or in combination with phacoemulsification, in open-angle glaucoma patients</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To compare the efficacy and safety of the XEN45 implant with that of trabeculectomy (TRAB), either alone or in combination with phacoemulsification (PHACO), in patients with open-angle glaucoma (OAG).
Methods
Retrospective, single-center and comparative study conducted on OAG patients. Patients were divided into four groups: group 1 (XEN alone); group 2 (XEN+PHACO); group 3 (TRAB alone); group 4 (TRAB+PHACO). For statistical purposes, groups 1 and 2 were combined (XEN implant), while groups 3 and 4 were also combined (TRAB surgery). The main outcome measure was intraocular pressure (IOP).
Results
Ninety-one patients (121 eyes; 65 XEN and 56 TRAB) were included. IOP reduction was − 6.7 (− 10.4 to − 3.0) mmHg,
p
= 0.0013; − 3.5 (− 5.0 to − 2.0) mmHg,
p
< 0.0001; − 8.1 (− 10.4 to − 5.9) mmHg,
p
< 0.0001l; and − 7.3 (− 9.3 to − 5.3) mmHg,
p
< 0.0001 in the XEN alone, XEN+PHACO, TRAB alone, and TRAB+PHACO, respectively. At month 12, an IOP ≥ 6 and ≤ 16 mm without treatment was achieved by 44 (67.7%) and 43 (76.8%),
p
= 0.2687 in the XEN implant and the TRAB surgery groups, respectively. The mean number of antiglaucoma medications was significantly reduced in all the study groups (
p
< 0.0001 each). Needling occurred in 20.0% (13/65) of eyes in the XEN implant group, while hyphema occurred in 30.4% (17/56) of eyes in the TRAB group.
Conclusions
XEN implant, either alone or in combination with phacoemulsification, significantly reduces both IOP and the number of antiglaucoma medications to a similar rate than trabeculectomy, but with a better safety profile.</description><subject>Eye</subject><subject>Glaucoma</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Patients</subject><subject>Surgery</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kUtv1TAQhS0EopfCH2CBLLFh0cD4kThZoqo8pKrdFOnuLMee3LpK7GAnre6WX47bW0Bi0dVYOt85M9Yh5C2DjwxAfcoAkqkKWFeBFJJV-2dkw6SoKwV8-5xsQHFWtYJvj8irnG-g8KJmL8mRYNAJ1TQb8mt7dkH9NI8mLNThrbdIbzHlNdMlmR7tOqJd4rQ_oeiXa0zUjDEgjYn6QG2ceh_M4mOgd0Wm87WxEad1zH7w9kE4uQfjjKEyYTci3Y1mLT5D5yJjWPJr8mIwY8Y3j_OY_PhydnX6rTq__Pr99PN5ZYWql6qtOzTSSGBD16CzTetMV_dt6xzUrleudbIR0De1Qck4V-XZOzXYth_MMIA4Jh8OuXOKP1fMi558tjiWr2Ncs-ZccBCNaGVB3_-H3sQ1hXJdoXgtOwFQF4ofKJtizgkHPSc_mbTXDPR9Q_rQkC4N6YeG9L6Y3j1Gr_2E7q_lTyUFEAcgFynsMP3b_UTsb8w0nz4</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Marcos Parra, María Teresa</creator><creator>Salinas López, Javier Alejandro</creator><creator>López Grau, Noelia Soledad</creator><creator>Ceausescu, Ana María</creator><creator>Pérez Santonja, Juan José</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190801</creationdate><title>XEN implant device versus trabeculectomy, either alone or in combination with phacoemulsification, in open-angle glaucoma patients</title><author>Marcos Parra, María Teresa ; Salinas López, Javier Alejandro ; López Grau, Noelia Soledad ; Ceausescu, Ana María ; Pérez Santonja, Juan José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-859ea4a401f96edc68da95b88dd05db7d8d4630b65ae412270b6bd7fc8bfaff03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Eye</topic><topic>Glaucoma</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Patients</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marcos Parra, María Teresa</creatorcontrib><creatorcontrib>Salinas López, Javier Alejandro</creatorcontrib><creatorcontrib>López Grau, Noelia Soledad</creatorcontrib><creatorcontrib>Ceausescu, Ana María</creatorcontrib><creatorcontrib>Pérez Santonja, Juan José</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marcos Parra, María Teresa</au><au>Salinas López, Javier Alejandro</au><au>López Grau, Noelia Soledad</au><au>Ceausescu, Ana María</au><au>Pérez Santonja, Juan José</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>XEN implant device versus trabeculectomy, either alone or in combination with phacoemulsification, in open-angle glaucoma patients</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>257</volume><issue>8</issue><spage>1741</spage><epage>1750</epage><pages>1741-1750</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
To compare the efficacy and safety of the XEN45 implant with that of trabeculectomy (TRAB), either alone or in combination with phacoemulsification (PHACO), in patients with open-angle glaucoma (OAG).
Methods
Retrospective, single-center and comparative study conducted on OAG patients. Patients were divided into four groups: group 1 (XEN alone); group 2 (XEN+PHACO); group 3 (TRAB alone); group 4 (TRAB+PHACO). For statistical purposes, groups 1 and 2 were combined (XEN implant), while groups 3 and 4 were also combined (TRAB surgery). The main outcome measure was intraocular pressure (IOP).
Results
Ninety-one patients (121 eyes; 65 XEN and 56 TRAB) were included. IOP reduction was − 6.7 (− 10.4 to − 3.0) mmHg,
p
= 0.0013; − 3.5 (− 5.0 to − 2.0) mmHg,
p
< 0.0001; − 8.1 (− 10.4 to − 5.9) mmHg,
p
< 0.0001l; and − 7.3 (− 9.3 to − 5.3) mmHg,
p
< 0.0001 in the XEN alone, XEN+PHACO, TRAB alone, and TRAB+PHACO, respectively. At month 12, an IOP ≥ 6 and ≤ 16 mm without treatment was achieved by 44 (67.7%) and 43 (76.8%),
p
= 0.2687 in the XEN implant and the TRAB surgery groups, respectively. The mean number of antiglaucoma medications was significantly reduced in all the study groups (
p
< 0.0001 each). Needling occurred in 20.0% (13/65) of eyes in the XEN implant group, while hyphema occurred in 30.4% (17/56) of eyes in the TRAB group.
Conclusions
XEN implant, either alone or in combination with phacoemulsification, significantly reduces both IOP and the number of antiglaucoma medications to a similar rate than trabeculectomy, but with a better safety profile.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31093766</pmid><doi>10.1007/s00417-019-04341-y</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2019-08, Vol.257 (8), p.1741-1750 |
| issn | 0721-832X 1435-702X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2232036384 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Eye Glaucoma Medicine Medicine & Public Health Ophthalmology Patients Surgery |
| title | XEN implant device versus trabeculectomy, either alone or in combination with phacoemulsification, in open-angle glaucoma patients |
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