Tandem [4+1+1] Annulation Approach to 4‑Acyl-3,4-dihydropyrrolo[1,2‑a]pyrazines: Diastereoselective Construction of Dihydropyrazine Units from Pyrroles

Efficient construction of new chemical space by way of strategic use of tandem reactions is highly important in drug discovery. Described herein is an atom-economical [4+1+1] annulation approach to 3-(hetero)­aryl-4-acyl-3,4-dihydropyrrolo­[1,2-a]­pyrazines, a new chemical space, via a one-pot three...

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Veröffentlicht in:	Journal of organic chemistry 2019-06, Vol.84 (11), p.6916-6927
Hauptverfasser:	Dagar, Anuradha, Bae, Gi Hun, Lee, Jeong Hwa, Kim, Ikyon
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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