Development of Octreotide-Loaded Chitosan and Heparin Nanoparticles: Evaluation of Surface Modification Effect on Physicochemical Properties and Macrophage Uptake

Octreotide (OCT) is a therapeutic peptide which is administered for the treatment of acromegaly. The purpose of this study was to design a new polyethylene glycol (PEG)–conjugated nanoparticle (PEG-NP) to overcome the short half-life and poor stability of OCT. The developed PEG-NPs were compared wit...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2019-09, Vol.108 (9), p.3036-3045
Hauptverfasser:	Ghofrani, Mahdieh, Shirmard, Leila Rezaie, Dehghankelishadi, Pouya, Amini, Mohsen, Dorkoosh, Farid A.
Format:	Artikel
Sprache:	eng
Schlagworte:	chitosan drug delivery system(s) heparin peptide delivery polyethylene glycol
Online-Zugang:	Volltext
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