The role of complement membrane attack complex in dry and wet AMD - From hypothesis to clinical trials

Data from human dry and wet age-related macular degeneration (AMD) eyes support the hypothesis that constant ‘tickover’ of the alternative complement pathway results in chronic deposition of the complement membrane attack complex (MAC) on the choriocapillaris and the retinal pigment epithelium (RPE)...

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Veröffentlicht in:	Experimental eye research 2019-07, Vol.184, p.266-277
1. Verfasser:	Kumar-Singh, Rajendra
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus age-related macular degeneration Animals CD59 CD59 Antigens - genetics CD59 Antigens - therapeutic use Clinical Trials as Topic Complement Complement Membrane Attack Complex - physiology Dependovirus - genetics gene therapy Genetic Therapy Genetic Vectors Geographic atrophy Geographic Atrophy - physiopathology Geographic Atrophy - therapy Humans Intravitreal Injections Membrane attack complex Wet Macular Degeneration - physiopathology Wet Macular Degeneration - therapy
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