Cmtm7 knockout inhibits B-1a cell development at the transitional (TrB-1a) stage

Innate-like B-1a cells are an important cell population for production of natural IgM and interleukin-10 (IL-10), and act as the first line against pathogens. We determined that CMTM7 is essential for B-1a cell development. Following Cmtm7 (CKLF-like MARVEL transmembrane domain-containing 7) knockou...

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Veröffentlicht in:	International immunology 2019-11, Vol.31 (11), p.715-728
Hauptverfasser:	Liu, Zhengyang, Liu, Yuan, Li, Ting, Wang, Pingzhang, Mo, Xiaoning, Lv, Ping, Ge, Qing, Ma, Dalong, Han, Wenling
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocyte Subsets - immunology Cell Death Cell Proliferation Chemokines - deficiency Chemokines - immunology MARVEL Domain-Containing Proteins - deficiency MARVEL Domain-Containing Proteins - immunology Mice Mice, Inbred C57BL Mice, Knockout Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - immunology
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