Mechanisms of Genomic Instability in Breast Cancer

Breast cancer is the most common cancer among women globally. Genomic instability (GI) refers to the increased tendency to accrue genomic alterations. It drives heterogeneity and is a hallmark of cancer. Genomic integrity is closely guarded by several mechanisms, including DNA damage checkpoints, th...

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Veröffentlicht in:	Trends in molecular medicine 2019-07, Vol.25 (7), p.595-611
Hauptverfasser:	Duijf, Pascal H.G., Nanayakkara, Devathri, Nones, Katia, Srihari, Sriganesh, Kalimutho, Murugan, Khanna, Kum Kum
Format:	Artikel
Sprache:	eng
Schlagworte:	aneuploidy breast cancer chromosome instability DNA damage repair genomic instability
Online-Zugang:	Volltext
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