Novel stable analogues of the neurotensin C-terminal hexapeptide containing unnatural amino acids

Neurotensin (NT) (pGlu–Leu–Tyr–Glu–Asn–Lys–Pro–Arg–Arg–Pro–Tyr–Ile–Leu) exerts a dual function as a neurotransmitter/neuromodulator in the central nervous system and as a hormone/cellular mediator in periphery. This dual function of NT establishes a connection between brain and peripheral tissues th...

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Veröffentlicht in:	Amino acids 2019-07, Vol.51 (7), p.1009-1022
Hauptverfasser:	Magafa, Vassiliki, Matsoukas, Minos-Timotheos, Karageorgos, Vlasios, Dermitzaki, Eirini, Exarchakou, Revekka, Stylos, Evgenios Κ., Pardalos, Michail, Margioris, Andrew N., Varvounis, George, Tzakos, Andreas G., Spyroulias, Georgios A., Liapakis, George
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Amino Acid Sequence Amino acids Amino Acids - chemistry Analytical Chemistry Arginine Binding Biochemical Engineering Biochemistry Biomedical and Life Sciences Brain Central nervous system Chemistry Techniques, Synthetic Chromatography, High Pressure Liquid Deactivation Energy balance Enzymatic activity Half-life Homeostasis HT29 Cells Humans Life Sciences Lysine Mass Spectrometry Metabolism Models, Molecular Molecular Dynamics Simulation Neurobiology Neuromodulation Neurotensin Neurotensin - chemistry Neurotrophin 4 Neurotrophin 5 Organic chemistry Original Article Peptides Peptidomimetics - chemical synthesis Peptidomimetics - metabolism Peptidomimetics - pharmacology Pharmacology Proteolysis Proteomics Receptors Receptors, Neurotensin - chemistry Solitary tract nucleus Stability analysis Synthesis Tyrosine
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