microRNA-4532 inhibition protects human lens epithelial cells from ultra-violet-induced oxidative injury via activating SIRT6-Nrf2 signaling

Ultra-violet radiation (UVR) can induce significant oxidative injury to human lens epithelial cells (HLECs). Sirtuin 6 (SIRT6) is shown to directly bind to Nrf2, essential for Nrf2 signaling activation. In the present study, we show that microRNA-4532 (miR-4532) targets SIRT6 to regulate Nrf2 signal...

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Veröffentlicht in:	Biochemical and biophysical research communications 2019-06, Vol.514 (3), p.777-784
Hauptverfasser:	Sun, Guang-li, Huang, Dan, Li, Ke-ran, Jiang, Qin
Format:	Artikel
Sprache:	eng
Schlagworte:	Human lens epithelial cells microRNA-4532 SIRT6 and Nrf2 Ultra-violet radiation
Online-Zugang:	Volltext
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