Tunable and Reversible Substrate Stiffness Reveals a Dynamic Mechanosensitivity of Cardiomyocytes

New directions in material applications have allowed for the fresh insight into the coordination of biophysical cues and regulators. Although the role of the mechanical microenvironment on cell responses and mechanics is often studied, most analyses only consider static environments and behavior, ho...

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Veröffentlicht in:	ACS applied materials & interfaces 2019-06, Vol.11 (23), p.20603-20614
Hauptverfasser:	Corbin, Elise A, Vite, Alexia, Peyster, Eliot G, Bhoopalam, Myan, Brandimarto, Jeffrey, Wang, Xiao, Bennett, Alexander I, Clark, Andy T, Cheng, Xuemei, Turner, Kevin T, Musunuru, Kiran, Margulies, Kenneth B
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Cell Differentiation - physiology Cell Division - physiology Dimethylpolysiloxanes - chemistry Elastomers - chemistry Extracellular Matrix - metabolism Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Models, Theoretical Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Real-Time Polymerase Chain Reaction Sarcomeres - metabolism
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