In Vivo-Relevant Transwell Dish-Based Dissolution Testing for Orally Inhaled Corticosteroid Products

Purpose To establish an in vivo -relevant Transwell dish-based dissolution test system for the “respirable” aerosols of inhaled corticosteroids (ICSs) using marketed inhaler products. Methods “Respirable” ≤ 5.8 or 6.5 μm aerosols of 7 ICSs from 11 inhaler products were collected onto the filter memb...

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Veröffentlicht in:	Pharmaceutical research 2019-07, Vol.36 (7), p.95-11, Article 95
Hauptverfasser:	Sakagami, Masahiro, Li, Hua, Venitz, Jügen
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Corticoids Corticosteroids Dissolution Fluticasone Formulations Immunomodulators Lungs Medical Law Membranes Pharmacology/Toxicology Pharmacy Propionic acid Relative humidity Research Paper Solubility Test systems
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