Human Induced Pluripotent Stem Cell–Derived Cardiomyocyte Patch in Rats With Heart Failure

To treat chronic heart failure (CHF), we developed a robust, easy to handle bioabsorbable tissue-engineered patch embedded with human neonatal fibroblasts and human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs). This patch was implanted on the epicardial surface of the heart cover...

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Veröffentlicht in:	The Annals of thoracic surgery 2019-10, Vol.108 (4), p.1169-1177
Hauptverfasser:	Lancaster, Jordan J., Sanchez, Pablo, Repetti, Giuliana G., Juneman, Elizabeth, Pandey, Amitabh C., Chinyere, Ikeotunye R., Moukabary, Talal, LaHood, Nicole, Daugherty, Sherry L., Goldman, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Fibroblasts - transplantation Heart Failure - therapy Humans Induced Pluripotent Stem Cells - transplantation Myocytes, Cardiac - transplantation Rats Rats, Sprague-Dawley Surgical Mesh Tissue Engineering Tissue Scaffolds Ventricular Function, Left
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