Comparison of vitamin B12, vitamin D and folic acid blood levels in patients with schizophrenia, drug addiction and controls
•No study has compared vitamin deficiencies in schizophrenia (SCH), substance use disorder (SUD).•Vitamin deficiencies were widespread in SUD and SCH in this study.•B12 deficiencies were more common in SCH, and folic acid deficiencies were more prevalent in SUD.•Interestingly, the SUD group had the...
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| Veröffentlicht in: | Journal of clinical neuroscience 2019-07, Vol.65, p.11-16 |
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| creator | Yazici, Ahmet Bulent Akcay Ciner, Ozlem Yazici, Esra Cilli, Ali Savas Dogan, Burcu Erol, Atila |
| description | •No study has compared vitamin deficiencies in schizophrenia (SCH), substance use disorder (SUD).•Vitamin deficiencies were widespread in SUD and SCH in this study.•B12 deficiencies were more common in SCH, and folic acid deficiencies were more prevalent in SUD.•Interestingly, the SUD group had the highest vitamin D levels even including control group.•The rates of vitamin deficiencies were strikingly high in all the groups.
Schizophrenia (SCH) and drug addiction are chronic disorders that are frequently accompanied by physical diseases, poor nutrition and reduced self-care, all of which are likely to result in vitamin deficiencies. The objective of this study was to compare vitamin levels in SCH patients, substance use disorder (SUD) patients and healthy controls (HCs). The study included 189 SCH patients, 119 SUD patients and 109 HCs. Information on vitamin B12, folic acid and vitamin D levels were retrieved from the hospital’s database, and mean values and deficiency/insufficiency were evaluated. Vitamin D deficiency ( |
| doi_str_mv | 10.1016/j.jocn.2019.04.031 |
| format | Article |
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Schizophrenia (SCH) and drug addiction are chronic disorders that are frequently accompanied by physical diseases, poor nutrition and reduced self-care, all of which are likely to result in vitamin deficiencies. The objective of this study was to compare vitamin levels in SCH patients, substance use disorder (SUD) patients and healthy controls (HCs). The study included 189 SCH patients, 119 SUD patients and 109 HCs. Information on vitamin B12, folic acid and vitamin D levels were retrieved from the hospital’s database, and mean values and deficiency/insufficiency were evaluated. Vitamin D deficiency (<30 ng/ml) was more common in the SCH group than in the SUD and HC groups (88.4%, 74.8% and 86.4%, respectively). Although there were no significant differences in folic acid deficiency (<3.0 ng/ml) in the SUD and SCH groups (15.1% and 8.5%, respectively), the incidence of folic acid deficiency was significantly higher in both groups as compared with that in the HC group (5.8%). Significantly higher numbers of patients in the SCH group than in the SUD group had vitamin B12 deficiency (45.5% vs. 28.3%). The prevalence of vitamin B12 deficiency in the SUD group was significantly higher than that the HC group (28.3% vs.11.5%). As compared with the HC group, vitamin D and B12 levels were significantly lower in SCH group, and folic acid and B12 levels were significantly lower in the SUD group. Several vitamin deficiencies appear to be common in both SCH and SUD. Possible reasons should be investigated.</description><identifier>ISSN: 0967-5868</identifier><identifier>EISSN: 1532-2653</identifier><identifier>DOI: 10.1016/j.jocn.2019.04.031</identifier><identifier>PMID: 31076249</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Adult ; Drug addiction ; Female ; Folic acid ; Folic Acid - blood ; Folic Acid Deficiency - epidemiology ; Humans ; Incidence ; Male ; Middle Aged ; Prevalence ; Schizophrenia ; Schizophrenia - blood ; Substance-Related Disorders - blood ; Vitamin B 12 - blood ; Vitamin B 12 Deficiency - epidemiology ; Vitamin B12 ; Vitamin D ; Vitamin D - blood ; Vitamin D Deficiency - epidemiology</subject><ispartof>Journal of clinical neuroscience, 2019-07, Vol.65, p.11-16</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-ba2405a7d19221e273865cf18137405b18a120ffcf5317c7f4745496547d12303</citedby><cites>FETCH-LOGICAL-c356t-ba2405a7d19221e273865cf18137405b18a120ffcf5317c7f4745496547d12303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jocn.2019.04.031$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31076249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yazici, Ahmet Bulent</creatorcontrib><creatorcontrib>Akcay Ciner, Ozlem</creatorcontrib><creatorcontrib>Yazici, Esra</creatorcontrib><creatorcontrib>Cilli, Ali Savas</creatorcontrib><creatorcontrib>Dogan, Burcu</creatorcontrib><creatorcontrib>Erol, Atila</creatorcontrib><title>Comparison of vitamin B12, vitamin D and folic acid blood levels in patients with schizophrenia, drug addiction and controls</title><title>Journal of clinical neuroscience</title><addtitle>J Clin Neurosci</addtitle><description>•No study has compared vitamin deficiencies in schizophrenia (SCH), substance use disorder (SUD).•Vitamin deficiencies were widespread in SUD and SCH in this study.•B12 deficiencies were more common in SCH, and folic acid deficiencies were more prevalent in SUD.•Interestingly, the SUD group had the highest vitamin D levels even including control group.•The rates of vitamin deficiencies were strikingly high in all the groups.
Schizophrenia (SCH) and drug addiction are chronic disorders that are frequently accompanied by physical diseases, poor nutrition and reduced self-care, all of which are likely to result in vitamin deficiencies. The objective of this study was to compare vitamin levels in SCH patients, substance use disorder (SUD) patients and healthy controls (HCs). The study included 189 SCH patients, 119 SUD patients and 109 HCs. Information on vitamin B12, folic acid and vitamin D levels were retrieved from the hospital’s database, and mean values and deficiency/insufficiency were evaluated. Vitamin D deficiency (<30 ng/ml) was more common in the SCH group than in the SUD and HC groups (88.4%, 74.8% and 86.4%, respectively). Although there were no significant differences in folic acid deficiency (<3.0 ng/ml) in the SUD and SCH groups (15.1% and 8.5%, respectively), the incidence of folic acid deficiency was significantly higher in both groups as compared with that in the HC group (5.8%). Significantly higher numbers of patients in the SCH group than in the SUD group had vitamin B12 deficiency (45.5% vs. 28.3%). The prevalence of vitamin B12 deficiency in the SUD group was significantly higher than that the HC group (28.3% vs.11.5%). As compared with the HC group, vitamin D and B12 levels were significantly lower in SCH group, and folic acid and B12 levels were significantly lower in the SUD group. Several vitamin deficiencies appear to be common in both SCH and SUD. Possible reasons should be investigated.</description><subject>Adult</subject><subject>Drug addiction</subject><subject>Female</subject><subject>Folic acid</subject><subject>Folic Acid - blood</subject><subject>Folic Acid Deficiency - epidemiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Schizophrenia</subject><subject>Schizophrenia - blood</subject><subject>Substance-Related Disorders - blood</subject><subject>Vitamin B 12 - blood</subject><subject>Vitamin B 12 Deficiency - epidemiology</subject><subject>Vitamin B12</subject><subject>Vitamin D</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - epidemiology</subject><issn>0967-5868</issn><issn>1532-2653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1vEzEQhi1ERdPAH-CAfOTQXTz-2l2JCwQKSJV6KWfL8QdxtLtebCcI1B-Po5QeOY1G877PSA9Cr4G0QEC-27f7aOaWEhhawlvC4BlagWC0oVKw52hFBtk1opf9JbrKeU8IGTgjL9AlA9JJyocVetjEadEp5Djj6PExFD2FGX8Eev20fMJ6ttjHMRisTbB4O8Zo8eiObsy4BhZdgptLxr9C2eFsduFPXHbJzUFfY5sOP7C2NpgS6pMTysS5pDjml-jC6zG7V49zjb7ffL7ffG1u775823y4bQwTsjRbTTkRurMwUAqOdqyXwnjogXX1sIVeAyXeGy8YdKbzvOOCD1LwWqGMsDV6e-YuKf48uFzUFLJx46hnFw9ZUcpgIJJX8hrRc9SkmHNyXi0pTDr9VkDUybraq5N1dbKuCFfVei29eeQftpOzT5V_mmvg_TlQhbljcEllU40ZZ0Nypigbw__4fwHaO5Kd</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Yazici, Ahmet Bulent</creator><creator>Akcay Ciner, Ozlem</creator><creator>Yazici, Esra</creator><creator>Cilli, Ali Savas</creator><creator>Dogan, Burcu</creator><creator>Erol, Atila</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190701</creationdate><title>Comparison of vitamin B12, vitamin D and folic acid blood levels in patients with schizophrenia, drug addiction and controls</title><author>Yazici, Ahmet Bulent ; Akcay Ciner, Ozlem ; Yazici, Esra ; Cilli, Ali Savas ; Dogan, Burcu ; Erol, Atila</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-ba2405a7d19221e273865cf18137405b18a120ffcf5317c7f4745496547d12303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Drug addiction</topic><topic>Female</topic><topic>Folic acid</topic><topic>Folic Acid - blood</topic><topic>Folic Acid Deficiency - epidemiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Schizophrenia</topic><topic>Schizophrenia - blood</topic><topic>Substance-Related Disorders - blood</topic><topic>Vitamin B 12 - blood</topic><topic>Vitamin B 12 Deficiency - epidemiology</topic><topic>Vitamin B12</topic><topic>Vitamin D</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yazici, Ahmet Bulent</creatorcontrib><creatorcontrib>Akcay Ciner, Ozlem</creatorcontrib><creatorcontrib>Yazici, Esra</creatorcontrib><creatorcontrib>Cilli, Ali Savas</creatorcontrib><creatorcontrib>Dogan, Burcu</creatorcontrib><creatorcontrib>Erol, Atila</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yazici, Ahmet Bulent</au><au>Akcay Ciner, Ozlem</au><au>Yazici, Esra</au><au>Cilli, Ali Savas</au><au>Dogan, Burcu</au><au>Erol, Atila</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of vitamin B12, vitamin D and folic acid blood levels in patients with schizophrenia, drug addiction and controls</atitle><jtitle>Journal of clinical neuroscience</jtitle><addtitle>J Clin Neurosci</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>65</volume><spage>11</spage><epage>16</epage><pages>11-16</pages><issn>0967-5868</issn><eissn>1532-2653</eissn><abstract>•No study has compared vitamin deficiencies in schizophrenia (SCH), substance use disorder (SUD).•Vitamin deficiencies were widespread in SUD and SCH in this study.•B12 deficiencies were more common in SCH, and folic acid deficiencies were more prevalent in SUD.•Interestingly, the SUD group had the highest vitamin D levels even including control group.•The rates of vitamin deficiencies were strikingly high in all the groups.
Schizophrenia (SCH) and drug addiction are chronic disorders that are frequently accompanied by physical diseases, poor nutrition and reduced self-care, all of which are likely to result in vitamin deficiencies. The objective of this study was to compare vitamin levels in SCH patients, substance use disorder (SUD) patients and healthy controls (HCs). The study included 189 SCH patients, 119 SUD patients and 109 HCs. Information on vitamin B12, folic acid and vitamin D levels were retrieved from the hospital’s database, and mean values and deficiency/insufficiency were evaluated. Vitamin D deficiency (<30 ng/ml) was more common in the SCH group than in the SUD and HC groups (88.4%, 74.8% and 86.4%, respectively). Although there were no significant differences in folic acid deficiency (<3.0 ng/ml) in the SUD and SCH groups (15.1% and 8.5%, respectively), the incidence of folic acid deficiency was significantly higher in both groups as compared with that in the HC group (5.8%). Significantly higher numbers of patients in the SCH group than in the SUD group had vitamin B12 deficiency (45.5% vs. 28.3%). The prevalence of vitamin B12 deficiency in the SUD group was significantly higher than that the HC group (28.3% vs.11.5%). As compared with the HC group, vitamin D and B12 levels were significantly lower in SCH group, and folic acid and B12 levels were significantly lower in the SUD group. Several vitamin deficiencies appear to be common in both SCH and SUD. Possible reasons should be investigated.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>31076249</pmid><doi>10.1016/j.jocn.2019.04.031</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Drug addiction Female Folic acid Folic Acid - blood Folic Acid Deficiency - epidemiology Humans Incidence Male Middle Aged Prevalence Schizophrenia Schizophrenia - blood Substance-Related Disorders - blood Vitamin B 12 - blood Vitamin B 12 Deficiency - epidemiology Vitamin B12 Vitamin D Vitamin D - blood Vitamin D Deficiency - epidemiology |
| title | Comparison of vitamin B12, vitamin D and folic acid blood levels in patients with schizophrenia, drug addiction and controls |
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