Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa

Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa

Eight new annonaceous acetogenins, squamotin A-D (1–4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9–12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activit...

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Veröffentlicht in:Chinese journal of natural medicines 2019-04, Vol.17 (4), p.291-297
Hauptverfasser: MA, Cheng-Yao, LU, Jia-Hui, LI, Xiang, LIU, Xiao, CHEN, Jian-Wei
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Annona squamosa
Annonaceous acetogenins
Cytotoxicity
Multidrug resistance
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LU, Jia-Hui
LI, Xiang
LIU, Xiao
CHEN, Jian-Wei
description Eight new annonaceous acetogenins, squamotin A-D (1–4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9–12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1–9 against three multidrug resistance cell lines were evaluated. All tested compounds showed strong cytotoxicity.
doi_str_mv 10.1016/S1875-5364(19)30032-9
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subjects Annona squamosa
Annonaceous acetogenins
Cytotoxicity
Multidrug resistance
title Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa
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