HLA-DQ Typing Kits in Diagnosis and Screening for Celiac Disease

Celiac disease (CD) is strongly associated with HLA-DQ2.2, HLA-DQ2.5, and HLA-DQ8. Up to 99.7% of all CD patients are positive for either one or two of these genetic markers, demonstrating a high negative predictive value. This has led to the development of diagnostic kits that, instead of providing...

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Veröffentlicht in:	Genetic testing and molecular biomarkers 2019-06, Vol.23 (6), p.418-422
Hauptverfasser:	Rouvroye, Maxine D, van Zijtveld, Sander, Bonnet, Petra, Spierings, Eric, Bontkes, Hetty J
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune diseases Celiac disease Deoxyribonucleic acid Diagnostic systems DNA Genetic markers Histocompatibility antigen HLA Homozygosity Reagents Sampling methods Tissue typing
Online-Zugang:	Volltext
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