Retrospective evaluation of paired plasma creatinine and chloride concentrations following hetastarch administration in anesthetized dogs (2002–2015): 244 cases

Objective To evaluate changes in serum creatinine and chloride concentrations in anesthetized dogs that received 6% hydroxyethyl starch (HES) 670/0.7. Design Retrospective case series, 2002–2015. Setting University veterinary teaching hospital. Animals Two hundred forty‐four client‐owned dogs underg...

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Veröffentlicht in:Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000) Tex. : 2000), 2019-05, Vol.29 (3), p.309-313
Hauptverfasser: Zersen, Kristin M., Mama, Khursheed, Mathis, Justin C.
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container_title Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000)
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creator Zersen, Kristin M.
Mama, Khursheed
Mathis, Justin C.
description Objective To evaluate changes in serum creatinine and chloride concentrations in anesthetized dogs that received 6% hydroxyethyl starch (HES) 670/0.7. Design Retrospective case series, 2002–2015. Setting University veterinary teaching hospital. Animals Two hundred forty‐four client‐owned dogs undergoing general anesthesia that received an HES solution. Interventions None. Measurements and Main Results Medical records of dogs that received an HES solution (6%, 670/0.7) while under general anesthesia during the study period were reviewed. Information obtained from the medical record included patient signalment, reason for anesthesia or diagnosis, body weight, amount of HES solution administered, pre‐ and postanesthesia creatinine value, pre‐ and postanesthesia chloride value, and day interval between measurements. Corrected chloride values were used for all statistical analysis. Dogs received a median dose of 6.3 mL/kg hetastarch during anesthesia. Median preanesthesia creatinine and corrected chloride values were 79.5 μmol/L (0.9 mg/dL) (range 8.8–689.5 μmol/L [0.1–7.8 mg/dL]) and 111 mmol/L (111 mEq/L) (range 80–123 mmol/L [80–123 mg/dL]), respectively. Median postanesthesia creatinine was 57.4 μmol/L (0.65 mg/dL) (8.8–716 μmol/L [0.1–8.1 mg/dL]). Median postanesthesia corrected chloride was 115 mmol/L (115 mEq/L) (range 87.5–129.6 mmol/L [87.5–129.6 mEq/L]). Mann–Whitney test analysis revealed a significant decrease in creatinine (Δ Cr 17.7 μmol/L [0.2 mg/dL], P < 0.01) and a significant increase in corrected chloride (Δ Cl 4.1 mmol/L [4.1mEq/L], P < 0.01) between pre‐ and postanesthesia values. Conclusions In a mixed population of hospitalized dogs undergoing general anesthesia that received a median dose of 6 mL/kg of HES, creatinine was lower and chloride was higher in the postanesthetic than in the preanesthetic period. The clinical significance of these changes and the role that HES administration played in them relative to concurrent therapies is unknown.
doi_str_mv 10.1111/vec.12836
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Design Retrospective case series, 2002–2015. Setting University veterinary teaching hospital. Animals Two hundred forty‐four client‐owned dogs undergoing general anesthesia that received an HES solution. Interventions None. Measurements and Main Results Medical records of dogs that received an HES solution (6%, 670/0.7) while under general anesthesia during the study period were reviewed. Information obtained from the medical record included patient signalment, reason for anesthesia or diagnosis, body weight, amount of HES solution administered, pre‐ and postanesthesia creatinine value, pre‐ and postanesthesia chloride value, and day interval between measurements. Corrected chloride values were used for all statistical analysis. Dogs received a median dose of 6.3 mL/kg hetastarch during anesthesia. Median preanesthesia creatinine and corrected chloride values were 79.5 μmol/L (0.9 mg/dL) (range 8.8–689.5 μmol/L [0.1–7.8 mg/dL]) and 111 mmol/L (111 mEq/L) (range 80–123 mmol/L [80–123 mg/dL]), respectively. Median postanesthesia creatinine was 57.4 μmol/L (0.65 mg/dL) (8.8–716 μmol/L [0.1–8.1 mg/dL]). Median postanesthesia corrected chloride was 115 mmol/L (115 mEq/L) (range 87.5–129.6 mmol/L [87.5–129.6 mEq/L]). Mann–Whitney test analysis revealed a significant decrease in creatinine (Δ Cr 17.7 μmol/L [0.2 mg/dL], P &lt; 0.01) and a significant increase in corrected chloride (Δ Cl 4.1 mmol/L [4.1mEq/L], P &lt; 0.01) between pre‐ and postanesthesia values. Conclusions In a mixed population of hospitalized dogs undergoing general anesthesia that received a median dose of 6 mL/kg of HES, creatinine was lower and chloride was higher in the postanesthetic than in the preanesthetic period. The clinical significance of these changes and the role that HES administration played in them relative to concurrent therapies is unknown.</description><identifier>ISSN: 1479-3261</identifier><identifier>EISSN: 1476-4431</identifier><identifier>DOI: 10.1111/vec.12836</identifier><identifier>PMID: 31066159</identifier><language>eng</language><publisher>United States</publisher><subject>Acute Kidney Injury - chemically induced ; Acute Kidney Injury - veterinary ; anesthesia ; Anesthesia, General - veterinary ; Animals ; Chlorides - blood ; colloids ; Creatinine - blood ; Dogs - blood ; Dogs - physiology ; electrolytes ; Female ; Hydroxyethyl Starch Derivatives - administration &amp; dosage ; Hydroxyethyl Starch Derivatives - adverse effects ; kidney function ; Male ; Plasma Substitutes - administration &amp; dosage ; Plasma Substitutes - adverse effects ; Records - veterinary ; Retrospective Studies</subject><ispartof>Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000), 2019-05, Vol.29 (3), p.309-313</ispartof><rights>Veterinary Emergency and Critical Care Society 2019</rights><rights>Veterinary Emergency and Critical Care Society 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3256-9d32e540accd954c08381344ad9a5c2a96033ba6399adc6df382aac69276ee453</citedby><cites>FETCH-LOGICAL-c3256-9d32e540accd954c08381344ad9a5c2a96033ba6399adc6df382aac69276ee453</cites><orcidid>0000-0003-0327-8537</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fvec.12836$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fvec.12836$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31066159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zersen, Kristin M.</creatorcontrib><creatorcontrib>Mama, Khursheed</creatorcontrib><creatorcontrib>Mathis, Justin C.</creatorcontrib><title>Retrospective evaluation of paired plasma creatinine and chloride concentrations following hetastarch administration in anesthetized dogs (2002–2015): 244 cases</title><title>Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000)</title><addtitle>J Vet Emerg Crit Care (San Antonio)</addtitle><description>Objective To evaluate changes in serum creatinine and chloride concentrations in anesthetized dogs that received 6% hydroxyethyl starch (HES) 670/0.7. Design Retrospective case series, 2002–2015. Setting University veterinary teaching hospital. Animals Two hundred forty‐four client‐owned dogs undergoing general anesthesia that received an HES solution. Interventions None. Measurements and Main Results Medical records of dogs that received an HES solution (6%, 670/0.7) while under general anesthesia during the study period were reviewed. Information obtained from the medical record included patient signalment, reason for anesthesia or diagnosis, body weight, amount of HES solution administered, pre‐ and postanesthesia creatinine value, pre‐ and postanesthesia chloride value, and day interval between measurements. Corrected chloride values were used for all statistical analysis. Dogs received a median dose of 6.3 mL/kg hetastarch during anesthesia. Median preanesthesia creatinine and corrected chloride values were 79.5 μmol/L (0.9 mg/dL) (range 8.8–689.5 μmol/L [0.1–7.8 mg/dL]) and 111 mmol/L (111 mEq/L) (range 80–123 mmol/L [80–123 mg/dL]), respectively. Median postanesthesia creatinine was 57.4 μmol/L (0.65 mg/dL) (8.8–716 μmol/L [0.1–8.1 mg/dL]). Median postanesthesia corrected chloride was 115 mmol/L (115 mEq/L) (range 87.5–129.6 mmol/L [87.5–129.6 mEq/L]). Mann–Whitney test analysis revealed a significant decrease in creatinine (Δ Cr 17.7 μmol/L [0.2 mg/dL], P &lt; 0.01) and a significant increase in corrected chloride (Δ Cl 4.1 mmol/L [4.1mEq/L], P &lt; 0.01) between pre‐ and postanesthesia values. Conclusions In a mixed population of hospitalized dogs undergoing general anesthesia that received a median dose of 6 mL/kg of HES, creatinine was lower and chloride was higher in the postanesthetic than in the preanesthetic period. The clinical significance of these changes and the role that HES administration played in them relative to concurrent therapies is unknown.</description><subject>Acute Kidney Injury - chemically induced</subject><subject>Acute Kidney Injury - veterinary</subject><subject>anesthesia</subject><subject>Anesthesia, General - veterinary</subject><subject>Animals</subject><subject>Chlorides - blood</subject><subject>colloids</subject><subject>Creatinine - blood</subject><subject>Dogs - blood</subject><subject>Dogs - physiology</subject><subject>electrolytes</subject><subject>Female</subject><subject>Hydroxyethyl Starch Derivatives - administration &amp; dosage</subject><subject>Hydroxyethyl Starch Derivatives - adverse effects</subject><subject>kidney function</subject><subject>Male</subject><subject>Plasma Substitutes - administration &amp; dosage</subject><subject>Plasma Substitutes - adverse effects</subject><subject>Records - veterinary</subject><subject>Retrospective Studies</subject><issn>1479-3261</issn><issn>1476-4431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtuFDEQhi0EIiGw4ALIy2TRiV_ttNmhUXhIkZAQsG1VytUZI3e7sXsmCivuwA04GifBzAzs8KYs-avPpfoZey7FuaznYkt4LlWn7QN2LM2lbYzR8uHu7hqtrDxiT0r5IoR0rlWP2ZGWwlrZumP28wMtOZWZcAlb4rSFuIElpImngc8QMnk-RygjcMxUX6YwEYfJc1zHlIMnjmlCmpa8ayt8SDGmuzDd8jUtUBbIuObgx9pZDhAPU1VQWSoRvtUffLot_FQJoX59_6GEbM9ecmUMRyhUnrJHA8RCzw71hH16ffVx9ba5fv_m3erVdYNatbZxXitqjQBE71qDotOd1MaAd9CiAmeF1jdgtXPg0fpBdwoArVOXlsi0-oSd7r1zTl83dbp-DAUpxjpq2pReKS0715nOVfRsj2LdXck09HMOI-T7Xor-TyR9jaTfRVLZFwft5mYk_4_8m0EFLvbAXYh0_39T__lqtVf-BmkrmHw</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Zersen, Kristin M.</creator><creator>Mama, Khursheed</creator><creator>Mathis, Justin C.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0327-8537</orcidid></search><sort><creationdate>201905</creationdate><title>Retrospective evaluation of paired plasma creatinine and chloride concentrations following hetastarch administration in anesthetized dogs (2002–2015): 244 cases</title><author>Zersen, Kristin M. ; Mama, Khursheed ; Mathis, Justin C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3256-9d32e540accd954c08381344ad9a5c2a96033ba6399adc6df382aac69276ee453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acute Kidney Injury - chemically induced</topic><topic>Acute Kidney Injury - veterinary</topic><topic>anesthesia</topic><topic>Anesthesia, General - veterinary</topic><topic>Animals</topic><topic>Chlorides - blood</topic><topic>colloids</topic><topic>Creatinine - blood</topic><topic>Dogs - blood</topic><topic>Dogs - physiology</topic><topic>electrolytes</topic><topic>Female</topic><topic>Hydroxyethyl Starch Derivatives - administration &amp; dosage</topic><topic>Hydroxyethyl Starch Derivatives - adverse effects</topic><topic>kidney function</topic><topic>Male</topic><topic>Plasma Substitutes - administration &amp; dosage</topic><topic>Plasma Substitutes - adverse effects</topic><topic>Records - veterinary</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zersen, Kristin M.</creatorcontrib><creatorcontrib>Mama, Khursheed</creatorcontrib><creatorcontrib>Mathis, Justin C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zersen, Kristin M.</au><au>Mama, Khursheed</au><au>Mathis, Justin C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retrospective evaluation of paired plasma creatinine and chloride concentrations following hetastarch administration in anesthetized dogs (2002–2015): 244 cases</atitle><jtitle>Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000)</jtitle><addtitle>J Vet Emerg Crit Care (San Antonio)</addtitle><date>2019-05</date><risdate>2019</risdate><volume>29</volume><issue>3</issue><spage>309</spage><epage>313</epage><pages>309-313</pages><issn>1479-3261</issn><eissn>1476-4431</eissn><abstract>Objective To evaluate changes in serum creatinine and chloride concentrations in anesthetized dogs that received 6% hydroxyethyl starch (HES) 670/0.7. Design Retrospective case series, 2002–2015. Setting University veterinary teaching hospital. Animals Two hundred forty‐four client‐owned dogs undergoing general anesthesia that received an HES solution. Interventions None. Measurements and Main Results Medical records of dogs that received an HES solution (6%, 670/0.7) while under general anesthesia during the study period were reviewed. Information obtained from the medical record included patient signalment, reason for anesthesia or diagnosis, body weight, amount of HES solution administered, pre‐ and postanesthesia creatinine value, pre‐ and postanesthesia chloride value, and day interval between measurements. Corrected chloride values were used for all statistical analysis. Dogs received a median dose of 6.3 mL/kg hetastarch during anesthesia. Median preanesthesia creatinine and corrected chloride values were 79.5 μmol/L (0.9 mg/dL) (range 8.8–689.5 μmol/L [0.1–7.8 mg/dL]) and 111 mmol/L (111 mEq/L) (range 80–123 mmol/L [80–123 mg/dL]), respectively. Median postanesthesia creatinine was 57.4 μmol/L (0.65 mg/dL) (8.8–716 μmol/L [0.1–8.1 mg/dL]). Median postanesthesia corrected chloride was 115 mmol/L (115 mEq/L) (range 87.5–129.6 mmol/L [87.5–129.6 mEq/L]). Mann–Whitney test analysis revealed a significant decrease in creatinine (Δ Cr 17.7 μmol/L [0.2 mg/dL], P &lt; 0.01) and a significant increase in corrected chloride (Δ Cl 4.1 mmol/L [4.1mEq/L], P &lt; 0.01) between pre‐ and postanesthesia values. Conclusions In a mixed population of hospitalized dogs undergoing general anesthesia that received a median dose of 6 mL/kg of HES, creatinine was lower and chloride was higher in the postanesthetic than in the preanesthetic period. The clinical significance of these changes and the role that HES administration played in them relative to concurrent therapies is unknown.</abstract><cop>United States</cop><pmid>31066159</pmid><doi>10.1111/vec.12836</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-0327-8537</orcidid></addata></record>
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subjects Acute Kidney Injury - chemically induced
Acute Kidney Injury - veterinary
anesthesia
Anesthesia, General - veterinary
Animals
Chlorides - blood
colloids
Creatinine - blood
Dogs - blood
Dogs - physiology
electrolytes
Female
Hydroxyethyl Starch Derivatives - administration & dosage
Hydroxyethyl Starch Derivatives - adverse effects
kidney function
Male
Plasma Substitutes - administration & dosage
Plasma Substitutes - adverse effects
Records - veterinary
Retrospective Studies
title Retrospective evaluation of paired plasma creatinine and chloride concentrations following hetastarch administration in anesthetized dogs (2002–2015): 244 cases
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