Role of Human Papillomavirus DNA Load in Predicting the Long-term Risk of Cervical Cancer: A 15-Year Prospective Cohort Study in China
Biomarkers highly predictive of cervical cancer are urgently needed for triaging human papillomavirus virus (HPV)–positive women. A 15-year prospective cohort study in China found that a moderate/high HPV load may accelerate the progression of cervical precancers and potentially could be used as a t...
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Veröffentlicht in: | The Journal of infectious diseases 2019-01, Vol.219 (2), p.215-222 |
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creator | Zhao, Xuelian Zhao, Shuang Hu, Shangying Zhao, Kevin Zhang, Qian Zhang, Xun Pan, Qinjing Zhao, Fanghui |
description | Biomarkers highly predictive of cervical cancer are urgently needed for triaging human papillomavirus virus (HPV)–positive women. A 15-year prospective cohort study in China found that a moderate/high HPV load may accelerate the progression of cervical precancers and potentially could be used as a triage indicator.
Abstract
Background
Biomarkers highly predictive of cervical cancer are urgently needed for triaging human papillomavirus (HPV)–positive women.
Methods
A total of 1997 women aged 35–45 years in Shanxi, China, were recruited in 1999, and follow-up visits were conducted in 2005, 2010, and 2014. HPV load was measured by the Hybrid Capture 2 assay. Findings were determined by relative light units/cutoff (RLU/CO) and categorized into 4 groups: negative ( |
doi_str_mv | 10.1093/infdis/jiy507 |
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Abstract
Background
Biomarkers highly predictive of cervical cancer are urgently needed for triaging human papillomavirus (HPV)–positive women.
Methods
A total of 1997 women aged 35–45 years in Shanxi, China, were recruited in 1999, and follow-up visits were conducted in 2005, 2010, and 2014. HPV load was measured by the Hybrid Capture 2 assay. Findings were determined by relative light units/cutoff (RLU/CO) and categorized into 4 groups: negative ( <1.0), low (range, 1.0 to <10.0), moderate (range, 10.0 to <100.0), and high (range, 100.0–∞). Cumulative incidence rates (CIRs) and adjusted hazard ratios (aHRs) for cervical intraepithelial neoplasia grade 2 or worse (CIN2+) were calculated for viral load subgroups, using survival analysis.
Results
Among 1739 women with normal or CIN1 pathological findings at baseline, 15-year CIRs for CIN2+ for those who were HPV negative and those with low, moderate, and high HPV loads groups were 3.1%, 8.4%, 19.9%, and 22.0%, respectively (Ptrend <.001). Compared with women who were negative for HPV from baseline through follow-up, those who had decreasing, increasing, or stable moderate/high loads had aHRs of 9.1, 38.7, or 379.7, respectively, for CIN2+. There was no significant difference between triage based on cytologic findings (for those with atypical squamous cells of undetermined significance or more-severe findings) and that based on a moderate/high HPV load for HPV primary screening (P = .343).
Conclusion
A moderate/high HPV load may accelerate the progression of cervical precancers and potentially could be used as a triage indicator for HPV-positive women.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiy507</identifier><identifier>PMID: 31067317</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Cervical cancer ; Cervix ; Cohort analysis ; Human papillomavirus ; Squamous cells ; Survival analysis ; VIRUSES</subject><ispartof>The Journal of infectious diseases, 2019-01, Vol.219 (2), p.215-222</ispartof><rights>The Author(s) 2018</rights><rights>The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2018</rights><rights>The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-2cb87e1f8821bd59072ae2e43c865fce7c86cec3fd383e36032f004c2d56562a3</citedby><cites>FETCH-LOGICAL-c415t-2cb87e1f8821bd59072ae2e43c865fce7c86cec3fd383e36032f004c2d56562a3</cites><orcidid>0000-0001-9294-0005</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31067317$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Xuelian</creatorcontrib><creatorcontrib>Zhao, Shuang</creatorcontrib><creatorcontrib>Hu, Shangying</creatorcontrib><creatorcontrib>Zhao, Kevin</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><creatorcontrib>Zhang, Xun</creatorcontrib><creatorcontrib>Pan, Qinjing</creatorcontrib><creatorcontrib>Zhao, Fanghui</creatorcontrib><title>Role of Human Papillomavirus DNA Load in Predicting the Long-term Risk of Cervical Cancer: A 15-Year Prospective Cohort Study in China</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Biomarkers highly predictive of cervical cancer are urgently needed for triaging human papillomavirus virus (HPV)–positive women. A 15-year prospective cohort study in China found that a moderate/high HPV load may accelerate the progression of cervical precancers and potentially could be used as a triage indicator.
Abstract
Background
Biomarkers highly predictive of cervical cancer are urgently needed for triaging human papillomavirus (HPV)–positive women.
Methods
A total of 1997 women aged 35–45 years in Shanxi, China, were recruited in 1999, and follow-up visits were conducted in 2005, 2010, and 2014. HPV load was measured by the Hybrid Capture 2 assay. Findings were determined by relative light units/cutoff (RLU/CO) and categorized into 4 groups: negative ( <1.0), low (range, 1.0 to <10.0), moderate (range, 10.0 to <100.0), and high (range, 100.0–∞). Cumulative incidence rates (CIRs) and adjusted hazard ratios (aHRs) for cervical intraepithelial neoplasia grade 2 or worse (CIN2+) were calculated for viral load subgroups, using survival analysis.
Results
Among 1739 women with normal or CIN1 pathological findings at baseline, 15-year CIRs for CIN2+ for those who were HPV negative and those with low, moderate, and high HPV loads groups were 3.1%, 8.4%, 19.9%, and 22.0%, respectively (Ptrend <.001). Compared with women who were negative for HPV from baseline through follow-up, those who had decreasing, increasing, or stable moderate/high loads had aHRs of 9.1, 38.7, or 379.7, respectively, for CIN2+. There was no significant difference between triage based on cytologic findings (for those with atypical squamous cells of undetermined significance or more-severe findings) and that based on a moderate/high HPV load for HPV primary screening (P = .343).
Conclusion
A moderate/high HPV load may accelerate the progression of cervical precancers and potentially could be used as a triage indicator for HPV-positive women.</description><subject>Cervical cancer</subject><subject>Cervix</subject><subject>Cohort analysis</subject><subject>Human papillomavirus</subject><subject>Squamous cells</subject><subject>Survival analysis</subject><subject>VIRUSES</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LAzEQhoMoWqtHj0rAi5e1-dgk22Opn1BUih48LWl2VlN3NzXZFfz3RrZW8OJpYObh5Z0HoSNKzikZ85FtysKG0dJ-CqK20IAKrhIpKd9GA0IYS2g2Hu-h_RCWhJCUS7WL9jglUnGqBuh57irArsQ3Xa0b_KBXtqpcrT-s7wK-uJvgmdMFtvHkobCmtc0Lbl8hrpuXpAVf47kNb98JU_Af1ugKT3VjwB-gnVJXAQ7Xc4ieri4fpzfJ7P76djqZJSalok2YWWQKaJlljC4KMSaKaWCQcpNJURpQcRowvCx4xoFLwlkZ_zCsEFJIpvkQnfW5K-_eOwhtXttgoKp0A64LOWM8KpAqFRE9_YMuXeeb2C5naaoykkV7kUp6yngXgocyX3lba_-ZU5J_O89753nvPPIn69RuUUOxoX8k_zZ03erfrOMeXYbW-Q3MpFBKMsW_AMlplHs</recordid><startdate>20190107</startdate><enddate>20190107</enddate><creator>Zhao, Xuelian</creator><creator>Zhao, Shuang</creator><creator>Hu, Shangying</creator><creator>Zhao, Kevin</creator><creator>Zhang, Qian</creator><creator>Zhang, Xun</creator><creator>Pan, Qinjing</creator><creator>Zhao, Fanghui</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9294-0005</orcidid></search><sort><creationdate>20190107</creationdate><title>Role of Human Papillomavirus DNA Load in Predicting the Long-term Risk of Cervical Cancer</title><author>Zhao, Xuelian ; Zhao, Shuang ; Hu, Shangying ; Zhao, Kevin ; Zhang, Qian ; Zhang, Xun ; Pan, Qinjing ; Zhao, Fanghui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-2cb87e1f8821bd59072ae2e43c865fce7c86cec3fd383e36032f004c2d56562a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Cervical cancer</topic><topic>Cervix</topic><topic>Cohort analysis</topic><topic>Human papillomavirus</topic><topic>Squamous cells</topic><topic>Survival analysis</topic><topic>VIRUSES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Xuelian</creatorcontrib><creatorcontrib>Zhao, Shuang</creatorcontrib><creatorcontrib>Hu, Shangying</creatorcontrib><creatorcontrib>Zhao, Kevin</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><creatorcontrib>Zhang, Xun</creatorcontrib><creatorcontrib>Pan, Qinjing</creatorcontrib><creatorcontrib>Zhao, Fanghui</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Xuelian</au><au>Zhao, Shuang</au><au>Hu, Shangying</au><au>Zhao, Kevin</au><au>Zhang, Qian</au><au>Zhang, Xun</au><au>Pan, Qinjing</au><au>Zhao, Fanghui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Human Papillomavirus DNA Load in Predicting the Long-term Risk of Cervical Cancer: A 15-Year Prospective Cohort Study in China</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2019-01-07</date><risdate>2019</risdate><volume>219</volume><issue>2</issue><spage>215</spage><epage>222</epage><pages>215-222</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Biomarkers highly predictive of cervical cancer are urgently needed for triaging human papillomavirus virus (HPV)–positive women. A 15-year prospective cohort study in China found that a moderate/high HPV load may accelerate the progression of cervical precancers and potentially could be used as a triage indicator.
Abstract
Background
Biomarkers highly predictive of cervical cancer are urgently needed for triaging human papillomavirus (HPV)–positive women.
Methods
A total of 1997 women aged 35–45 years in Shanxi, China, were recruited in 1999, and follow-up visits were conducted in 2005, 2010, and 2014. HPV load was measured by the Hybrid Capture 2 assay. Findings were determined by relative light units/cutoff (RLU/CO) and categorized into 4 groups: negative ( <1.0), low (range, 1.0 to <10.0), moderate (range, 10.0 to <100.0), and high (range, 100.0–∞). Cumulative incidence rates (CIRs) and adjusted hazard ratios (aHRs) for cervical intraepithelial neoplasia grade 2 or worse (CIN2+) were calculated for viral load subgroups, using survival analysis.
Results
Among 1739 women with normal or CIN1 pathological findings at baseline, 15-year CIRs for CIN2+ for those who were HPV negative and those with low, moderate, and high HPV loads groups were 3.1%, 8.4%, 19.9%, and 22.0%, respectively (Ptrend <.001). Compared with women who were negative for HPV from baseline through follow-up, those who had decreasing, increasing, or stable moderate/high loads had aHRs of 9.1, 38.7, or 379.7, respectively, for CIN2+. There was no significant difference between triage based on cytologic findings (for those with atypical squamous cells of undetermined significance or more-severe findings) and that based on a moderate/high HPV load for HPV primary screening (P = .343).
Conclusion
A moderate/high HPV load may accelerate the progression of cervical precancers and potentially could be used as a triage indicator for HPV-positive women.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>31067317</pmid><doi>10.1093/infdis/jiy507</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9294-0005</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Cervical cancer Cervix Cohort analysis Human papillomavirus Squamous cells Survival analysis VIRUSES |
title | Role of Human Papillomavirus DNA Load in Predicting the Long-term Risk of Cervical Cancer: A 15-Year Prospective Cohort Study in China |
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