70-year legacy of the Framingham Heart Study
The Framingham Heart Study (FHS) was established in 1948 to improve understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961, seminal work identified major risk factors for CHD (high blood pressure, high cholesterol levels and evidence on the electrocardiogram of left ve...
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| Veröffentlicht in: | Nature reviews cardiology 2019-11, Vol.16 (11), p.687-698 |
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| description | The Framingham Heart Study (FHS) was established in 1948 to improve understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961, seminal work identified major risk factors for CHD (high blood pressure, high cholesterol levels and evidence on the electrocardiogram of left ventricular hypertrophy), which later formed the basis for multivariable 10-year and 30-year risk-prediction algorithms. The FHS cohorts now comprise three generations of participants (
n
≈ 15,000) and two minority cohorts. The FHS cohorts are densely phenotyped, with recurring follow-up examinations and surveillance for cardiovascular and non-cardiovascular end points. Assessment of subclinical disease and physiological profiling of these cohorts (with the use of echocardiography, ambulatory electrocardiographic monitoring, exercise stress testing, cardiac CT, heart and brain MRI, serial vascular tonometry and accelerometry) have been performed repeatedly. Over the past decade, the FHS cohorts have undergone deep ‘omics’ profiling (including whole-genome sequencing, DNA methylation analysis, transcriptomics, high-throughput proteomics and metabolomics, and microbiome studies). The FHS is a rich, longitudinal, transgenerational and deeply phenotyped cohort study with a sustained focus on state-of-the-art epidemiological methods and technological advances to facilitate scientific discoveries.
The Framingham Heart Study (FHS) has been collecting epidemiological data on cardiovascular risk factors and disease for >70 years. In this Timeline Perspectives article, the authors summarize the major achievements of the FHS, highlight some of the seminal publications and discuss how epidemiological research has changed and continues to evolve. |
| doi_str_mv | 10.1038/s41569-019-0202-5 |
| format | Article |
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n
≈ 15,000) and two minority cohorts. The FHS cohorts are densely phenotyped, with recurring follow-up examinations and surveillance for cardiovascular and non-cardiovascular end points. Assessment of subclinical disease and physiological profiling of these cohorts (with the use of echocardiography, ambulatory electrocardiographic monitoring, exercise stress testing, cardiac CT, heart and brain MRI, serial vascular tonometry and accelerometry) have been performed repeatedly. Over the past decade, the FHS cohorts have undergone deep ‘omics’ profiling (including whole-genome sequencing, DNA methylation analysis, transcriptomics, high-throughput proteomics and metabolomics, and microbiome studies). The FHS is a rich, longitudinal, transgenerational and deeply phenotyped cohort study with a sustained focus on state-of-the-art epidemiological methods and technological advances to facilitate scientific discoveries.
The Framingham Heart Study (FHS) has been collecting epidemiological data on cardiovascular risk factors and disease for >70 years. In this Timeline Perspectives article, the authors summarize the major achievements of the FHS, highlight some of the seminal publications and discuss how epidemiological research has changed and continues to evolve.</description><identifier>ISSN: 1759-5002</identifier><identifier>EISSN: 1759-5010</identifier><identifier>DOI: 10.1038/s41569-019-0202-5</identifier><identifier>PMID: 31065045</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308 ; 692/4019/592/75 ; 692/499 ; 692/700/478/174 ; Cardiac Imaging ; Cardiac Surgery ; Cardiology ; Cardiovascular disease ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - history ; Cardiovascular research ; Coronary Artery Disease - epidemiology ; Coronary heart disease ; Data Collection - history ; DNA methylation ; Echocardiography ; Epidemiology ; Exercise Test ; Forecasts and trends ; Genomics ; Health risk assessment ; Heart ; History, 20th Century ; History, 21st Century ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging ; Manometry ; Medicine ; Medicine & Public Health ; Perspective ; Phenotype ; Population Surveillance ; Risk Factors ; Social aspects ; Tomography, X-Ray Computed</subject><ispartof>Nature reviews cardiology, 2019-11, Vol.16 (11), p.687-698</ispartof><rights>Springer Nature Limited 2019</rights><rights>COPYRIGHT 2019 Nature Publishing Group</rights><rights>Springer Nature Limited 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-364ec3fe04cc8333a82a3f6bdbae456abdabb75ded2e12754db9af3dbb13d10b3</citedby><cites>FETCH-LOGICAL-c536t-364ec3fe04cc8333a82a3f6bdbae456abdabb75ded2e12754db9af3dbb13d10b3</cites><orcidid>0000-0001-7357-5970 ; 0000-0003-4076-2336</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41569-019-0202-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41569-019-0202-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31065045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andersson, Charlotte</creatorcontrib><creatorcontrib>Johnson, Andrew D.</creatorcontrib><creatorcontrib>Benjamin, Emelia J.</creatorcontrib><creatorcontrib>Levy, Daniel</creatorcontrib><creatorcontrib>Vasan, Ramachandran S.</creatorcontrib><title>70-year legacy of the Framingham Heart Study</title><title>Nature reviews cardiology</title><addtitle>Nat Rev Cardiol</addtitle><addtitle>Nat Rev Cardiol</addtitle><description>The Framingham Heart Study (FHS) was established in 1948 to improve understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961, seminal work identified major risk factors for CHD (high blood pressure, high cholesterol levels and evidence on the electrocardiogram of left ventricular hypertrophy), which later formed the basis for multivariable 10-year and 30-year risk-prediction algorithms. The FHS cohorts now comprise three generations of participants (
n
≈ 15,000) and two minority cohorts. The FHS cohorts are densely phenotyped, with recurring follow-up examinations and surveillance for cardiovascular and non-cardiovascular end points. Assessment of subclinical disease and physiological profiling of these cohorts (with the use of echocardiography, ambulatory electrocardiographic monitoring, exercise stress testing, cardiac CT, heart and brain MRI, serial vascular tonometry and accelerometry) have been performed repeatedly. Over the past decade, the FHS cohorts have undergone deep ‘omics’ profiling (including whole-genome sequencing, DNA methylation analysis, transcriptomics, high-throughput proteomics and metabolomics, and microbiome studies). The FHS is a rich, longitudinal, transgenerational and deeply phenotyped cohort study with a sustained focus on state-of-the-art epidemiological methods and technological advances to facilitate scientific discoveries.
The Framingham Heart Study (FHS) has been collecting epidemiological data on cardiovascular risk factors and disease for >70 years. In this Timeline Perspectives article, the authors summarize the major achievements of the FHS, highlight some of the seminal publications and discuss how epidemiological research has changed and continues to evolve.</description><subject>692/308</subject><subject>692/4019/592/75</subject><subject>692/499</subject><subject>692/700/478/174</subject><subject>Cardiac Imaging</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - history</subject><subject>Cardiovascular research</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary heart disease</subject><subject>Data Collection - history</subject><subject>DNA methylation</subject><subject>Echocardiography</subject><subject>Epidemiology</subject><subject>Exercise Test</subject><subject>Forecasts and trends</subject><subject>Genomics</subject><subject>Health risk assessment</subject><subject>Heart</subject><subject>History, 20th Century</subject><subject>History, 21st Century</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Magnetic Resonance Imaging</subject><subject>Manometry</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Perspective</subject><subject>Phenotype</subject><subject>Population Surveillance</subject><subject>Risk Factors</subject><subject>Social aspects</subject><subject>Tomography, X-Ray Computed</subject><issn>1759-5002</issn><issn>1759-5010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUtr3DAUhUVpaZJpf0A3wVAoWcTTq6ft5RCaBwSyaLsWelzPONhWItmL-fexM0kmKSlCSOh-56DDIeQbhSUFXv5MgkpV5UCnzYDl8gM5pIWscgkUPr7cgR2Qo5RuAZQoJP9MDjgFJUHIQ3JaQL5FE7MW18Zts1Bnwwaz82i6pl9vTJddTtMh-z2MfvuFfKpNm_Dr07kgf89__Tm7zK9vLq7OVte5k1wNOVcCHa8RhHMl59yUzPBaWW8NCqmM9cbaQnr0DCkrpPC2MjX31lLuKVi-ICc737sY7kdMg-6a5LBtTY9hTJoxTsvqMcyCfP8HvQ1j7KffacZBFpWoAPbU2rSom74OQzRuNtUrBawUpeIztXyHmpbHrnGhx7qZ3t8IfrwSbNC0wyaFdhya0Ke3IN2BLoaUItb6LjadiVtNQc9V6l2VeqpSz1XqOdnxU7LRduhfFM_dTQDbAWka9WuM--j_d30A4p6kmA</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Andersson, Charlotte</creator><creator>Johnson, Andrew D.</creator><creator>Benjamin, Emelia J.</creator><creator>Levy, Daniel</creator><creator>Vasan, Ramachandran S.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7357-5970</orcidid><orcidid>https://orcid.org/0000-0003-4076-2336</orcidid></search><sort><creationdate>20191101</creationdate><title>70-year legacy of the Framingham Heart Study</title><author>Andersson, Charlotte ; Johnson, Andrew D. ; Benjamin, Emelia J. ; Levy, Daniel ; Vasan, Ramachandran S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-364ec3fe04cc8333a82a3f6bdbae456abdabb75ded2e12754db9af3dbb13d10b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>692/308</topic><topic>692/4019/592/75</topic><topic>692/499</topic><topic>692/700/478/174</topic><topic>Cardiac Imaging</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - history</topic><topic>Cardiovascular research</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary heart disease</topic><topic>Data Collection - history</topic><topic>DNA methylation</topic><topic>Echocardiography</topic><topic>Epidemiology</topic><topic>Exercise Test</topic><topic>Forecasts and trends</topic><topic>Genomics</topic><topic>Health risk assessment</topic><topic>Heart</topic><topic>History, 20th Century</topic><topic>History, 21st Century</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Magnetic Resonance Imaging</topic><topic>Manometry</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Perspective</topic><topic>Phenotype</topic><topic>Population Surveillance</topic><topic>Risk Factors</topic><topic>Social aspects</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andersson, Charlotte</creatorcontrib><creatorcontrib>Johnson, Andrew D.</creatorcontrib><creatorcontrib>Benjamin, Emelia J.</creatorcontrib><creatorcontrib>Levy, Daniel</creatorcontrib><creatorcontrib>Vasan, Ramachandran S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Nature reviews cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andersson, Charlotte</au><au>Johnson, Andrew D.</au><au>Benjamin, Emelia J.</au><au>Levy, Daniel</au><au>Vasan, Ramachandran S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>70-year legacy of the Framingham Heart Study</atitle><jtitle>Nature reviews cardiology</jtitle><stitle>Nat Rev Cardiol</stitle><addtitle>Nat Rev Cardiol</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>16</volume><issue>11</issue><spage>687</spage><epage>698</epage><pages>687-698</pages><issn>1759-5002</issn><eissn>1759-5010</eissn><abstract>The Framingham Heart Study (FHS) was established in 1948 to improve understanding of the epidemiology of coronary heart disease (CHD) in the USA. 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n
≈ 15,000) and two minority cohorts. The FHS cohorts are densely phenotyped, with recurring follow-up examinations and surveillance for cardiovascular and non-cardiovascular end points. Assessment of subclinical disease and physiological profiling of these cohorts (with the use of echocardiography, ambulatory electrocardiographic monitoring, exercise stress testing, cardiac CT, heart and brain MRI, serial vascular tonometry and accelerometry) have been performed repeatedly. Over the past decade, the FHS cohorts have undergone deep ‘omics’ profiling (including whole-genome sequencing, DNA methylation analysis, transcriptomics, high-throughput proteomics and metabolomics, and microbiome studies). The FHS is a rich, longitudinal, transgenerational and deeply phenotyped cohort study with a sustained focus on state-of-the-art epidemiological methods and technological advances to facilitate scientific discoveries.
The Framingham Heart Study (FHS) has been collecting epidemiological data on cardiovascular risk factors and disease for >70 years. In this Timeline Perspectives article, the authors summarize the major achievements of the FHS, highlight some of the seminal publications and discuss how epidemiological research has changed and continues to evolve.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31065045</pmid><doi>10.1038/s41569-019-0202-5</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-7357-5970</orcidid><orcidid>https://orcid.org/0000-0003-4076-2336</orcidid></addata></record> |
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| subjects | 692/308 692/4019/592/75 692/499 692/700/478/174 Cardiac Imaging Cardiac Surgery Cardiology Cardiovascular disease Cardiovascular Diseases - epidemiology Cardiovascular Diseases - history Cardiovascular research Coronary Artery Disease - epidemiology Coronary heart disease Data Collection - history DNA methylation Echocardiography Epidemiology Exercise Test Forecasts and trends Genomics Health risk assessment Heart History, 20th Century History, 21st Century Humans Longitudinal Studies Magnetic Resonance Imaging Manometry Medicine Medicine & Public Health Perspective Phenotype Population Surveillance Risk Factors Social aspects Tomography, X-Ray Computed |
| title | 70-year legacy of the Framingham Heart Study |
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