Caudatin potentiates the anti-tumor effects of TRAIL against human breast cancer by upregulating DR5

The ability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to preferentially induce apoptosis in transformed cells while sparing most normal cells is well established. However, the intrinsic and acquired resistance of tumors to TRAIL-induced apoptosis limits its therapeutic appli...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Phytomedicine (Stuttgart) 2019-09, Vol.62, p.152950-152950, Article 152950
Hauptverfasser:	Fei, Hong-rong, Yuan, Chuang, Wang, Gui-ling, Zhao, Ying, Li, Zhao-jun, Du, Xin, Wang, Feng-Ze
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Caudatin Cell Line, Tumor CHOP DR5 Female Gene Expression Regulation, Neoplastic Glycosides - pharmacology Humans MAPK MCF-7 Cells p38 Mitogen-Activated Protein Kinases - metabolism Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism Steroids - pharmacology TNF-Related Apoptosis-Inducing Ligand - metabolism TNF-Related Apoptosis-Inducing Ligand - pharmacology TRAIL Transcription Factor CHOP - genetics Transcription Factor CHOP - metabolism Up-Regulation - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!