The race between drug introduction and appearance of microbial resistance. Current balance and alternative approaches
As current levels of antimicrobial resistance are alarming, the World Health Organization urged the development of new antimicrobials to fight infections produced by multidrug resistant bacteria. Antibiotics impose severe selective pressure for the development of resistance, and currently bacteria r...
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| Veröffentlicht in: | Current opinion in pharmacology 2019-10, Vol.48, p.48-56 |
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| container_title | Current opinion in pharmacology |
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| creator | López-Jácome, Esaú Franco-Cendejas, Rafael Quezada, Héctor Morales-Espinosa, Rosario Castillo-Juárez, Israel González-Pedrajo, Bertha Fernández-Presas, Ana María Tovar-García, Arturo Angarita-Zapata, Vanesa Licona-Limón, Paula Martínez-Vázquez, Mariano García-Contreras, Rodolfo |
| description | As current levels of antimicrobial resistance are alarming, the World Health Organization urged the development of new antimicrobials to fight infections produced by multidrug resistant bacteria. Antibiotics impose severe selective pressure for the development of resistance, and currently bacteria resistant to all of them exist. In this review, we discuss the release and development of new antibacterial drugs and their properties as well as the current advances in the development of alternative approaches to combat bacterial infections, including the repurposing of drugs, anti-virulence therapies, the use of photosensitizers, phage therapy, and immunotherapies, with an emphasis on what is currently known about the possible development of bacterial resistance against them. |
| doi_str_mv | 10.1016/j.coph.2019.04.016 |
| format | Article |
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| title | The race between drug introduction and appearance of microbial resistance. Current balance and alternative approaches |
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