Stereocontrolled Synthesis of Boranophosphate DNA by an Oxazaphospholidine Approach and Evaluation of Its Properties

In this paper, we describe the first stereocontrolled synthesis and properties of boranophosphate DNA (PB-DNA), which contains all of the four nucleobases longer than 10mer. Synthesis was accomplished via an oxazaphospholidine approach combined with acid-labile protecting groups on nucleobases. It w...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of organic chemistry 2019-06, Vol.84 (12), p.7971-7983
Hauptverfasser:	Hara, Rintaro Iwata, Saito, Tatsuya, Kogure, Tomoki, Hamamura, Yuka, Uchiyama, Naoki, Nukaga, Yohei, Iwamoto, Naoki, Wada, Takeshi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!