Late glucocorticoid receptor antagonism changes the outcome of adult life stress

•Single Prolonged Stress (SPS) led to changed behavior, gene expression and corticosterone 14 days after stress•RU486 treatment 1 week after SPS had substantial effects on these parameters 1 week later.•RU486 effects occurred dependent and independent of stress history.•RU486 resulted partial normal...

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Veröffentlicht in:	Psychoneuroendocrinology 2019-09, Vol.107, p.169-178
Hauptverfasser:	Ding, Jinlan, da Silva, Marcia Santos, Lingeman, Jolanthe, Chen, Xinzhao, Shi, Yuxiu, Han, Fang, Meijer, Onno C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Affective disorders Animals Brain - metabolism Corticosterone - metabolism Disease Models, Animal Exploratory Behavior - drug effects Exploratory Behavior - physiology Extinction, Psychological - drug effects Extinction, Psychological - physiology Fear - drug effects Fear - physiology Hippocampus - metabolism Limbic brain Male Mifepristone Mifepristone - metabolism Mifepristone - pharmacology PACAP PTSD Rats Rats, Wistar Receptors, Glucocorticoid - antagonists & inhibitors Receptors, Glucocorticoid - metabolism Stress, Psychological - genetics Stress, Psychological - metabolism
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